Artículo
Abstract:
Iron deficiency is the most important nutritional problem all over the world. Fluid milk is an attractive vehicle for iron fortification, since it is a food with a high nutritional value, accessible to the whole population and easy to be given to children. Fortification of this food with iron has the disadvantage of the interaction of the iron with the constitutive elements of milk, diminishing its bioavailability and changing its sensorial properties, making it unacceptable. Nowadays, this problem can be overcome by the implementation of a new technological procedure, which consists in the microencapsulation of the ferrous sulfate with lecithin, thus avoiding the interaction of iron with the food. The absorption obtained in mice for milk-ferrous sulfate was 7.9±3.2%, while for microencapsulated ferrous sulfate-milk the result was 11.6±4.5%. Comparing these data with those obtained with the ferrous ascorbate in water 13.1±4.9% and ferrous sulfate in water 13.2±4.3%, both of them considered as reference standards, no statistically significant difference between them and the microencapsulated ferrous sulfate in milk can be observed. However, this difference becomes significant (p<0.01) when these products are compared to the non-encapsulated ferrous sulfate in milk. On the other hand, we demonstrated that this product is stable to heat-processing (100°C, 30min) and storage at a room temperature up to 6 months that lacteous products are usually submitted to.
Registro:
| Documento: | Artículo |
| Título: | Bioavailability and stability of microencapsulated ferrous sulfate in fluid milk: Studies in mice |
| Autor: | Boccio, J.R.; Zubillaga, M.B.; Caro, R.A.; Gotelli, C.A.; Gotelli, M.J.; Weill, R. |
| Filiación: | Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina Center of Toxicological Research, Buenos Aires, Argentina Center of Research and Development, La Serenísima, Buenos Aires, Argentina Mendoza 2779, 6oC, 1428-Buenos Aires, Argentina |
| Palabras clave: | Absorption; Ferrous sulfate; Fortification; Iron; Mice; Milk; ascorbic acid; ferrous ion; ferrous sulfate; phosphatidylcholine; absorption; animal; article; bioavailability; chemistry; drug formulation; drug stability; female; heat; milk; mouse; time; Absorption; Animals; Ascorbic Acid; Biological Availability; Drug Compounding; Drug Stability; Female; Ferrous Compounds; Heat; Mice; Milk; Phosphatidylcholines; Time Factors |
| Año: | 1996 |
| Volumen: | 42 |
| Número: | 3 |
| Página de inicio: | 233 |
| Página de fin: | 239 |
| DOI: | http://dx.doi.org/10.3177/jnsv.42.233 |
| Título revista: | Journal of Nutritional Science and Vitaminology |
| Título revista abreviado: | J. Nutr. Sci. Vitaminol. |
| ISSN: | 03014800 |
| CODEN: | JNSVA |
| CAS: | Ascorbic Acid, 50-81-7; Ferrous Compounds; ferrous sulfate, 7720-78-7; Phosphatidylcholines |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03014800_v42_n3_p233_Boccio |
Referencias:
- Hurrel, R.H., (1994) Iron Fortification on Infant Cereals, , Personal communication
- Portela, M.L.P.M., (1994) Vitaminas y Minerales en Nutrición, , Libreros López Editores, Buenos Aires, Argentina (in Spanish)
- Dallman, P.R., Hierro (1990) Present Knowledge in Nutrition, pp. 277-288. , Publicación Científica no 532, ed. by International Life Sciences Institute, ILSI Press, Organización Panamericana de la Salud, Washington, D. C
- Goodman Gilman, A., (1990) Goodman and Gilman's. The Pharmacological Basis of Therapeutics. 8th Ed., , Pergamon Press, New York
- Atukorala, M.T., Silva, L., Dechering, W., Dassenaeike, T., Perera, S., Evaluation of effectiveness of iron-folate supplementation and anthelminthic therapy against anemia in pregnancy - A study in the plantation sector of Sri Lanka (1994) Am. J. Clin. Nutr., 60, pp. 286-292
- Parr, R.M., Fjeld, C.R., Salud y nutrición humanas: La ayuda de los isótopos para erradicar el "hambre escondida." (1994) OIEA Boletín, 36, pp. 18-27. , in Spanish
- Heggenauer, J., Saltman, P., Bioavailable copper and iron in rat diets (1976) Am. J. Clin. Nutr., 29, pp. 936-938
- Sokal, R.R., Rohlf, F.J., (1969) Biometry, , W. H. Freeman and Company, San Francisco
- Hurrell, R., Lynch, S., Trinidad, T., Dassenko, S.A., Cook, J., Iron absorption in humans as influenced by bovine milk proteins (1989) Am. J. Clin. Nutr., 49, pp. 546-552
- Minotti, P., Buchowski, M., Miller, D., Effects of calcium supplementation, calcium source and lactose on iron absorption in the rat (1993) Nutr. Res., 13, pp. 1173-1181
- Monsen, E.R., Hallberg, L., Layrisse, M., Hegsted, D.M., Cook, J.D., Mertz, W., Finch, C.A., Estimation of available dietary iron (1978) Am. J. Clin. Nutr., 31, pp. 134-141
- Boccio, J., Zubillaga, M., Caro, R., Gotelli, C., Gotelli, M., Weill, R., New procedure to fortify fluid milk and derivatives with iron: A comparative study in mice (1995) J. Nutr. Sci. Vitaminol., 41, pp. 619-626
- Zubillaga, M., Caro, R., Boccio, J., Gotelli, C., Gotelli, M., Weill, R., New procedure to fortify fluid milk with iron: Metabolic and biochemical study in rats (1996) Nutr. Res., 16, pp. 131-137
Citas:
---------- APA ----------
Boccio, J.R., Zubillaga, M.B., Caro, R.A., Gotelli, C.A., Gotelli, M.J. & Weill, R. (1996) . Bioavailability and stability of microencapsulated ferrous sulfate in fluid milk: Studies in mice. Journal of Nutritional Science and Vitaminology, 42(3), 233-239.http://dx.doi.org/10.3177/jnsv.42.233
---------- CHICAGO ----------
Boccio, J.R., Zubillaga, M.B., Caro, R.A., Gotelli, C.A., Gotelli, M.J., Weill, R. "Bioavailability and stability of microencapsulated ferrous sulfate in fluid milk: Studies in mice" . Journal of Nutritional Science and Vitaminology 42, no. 3 (1996) : 233-239.http://dx.doi.org/10.3177/jnsv.42.233
---------- MLA ----------
Boccio, J.R., Zubillaga, M.B., Caro, R.A., Gotelli, C.A., Gotelli, M.J., Weill, R. "Bioavailability and stability of microencapsulated ferrous sulfate in fluid milk: Studies in mice" . Journal of Nutritional Science and Vitaminology, vol. 42, no. 3, 1996, pp. 233-239.http://dx.doi.org/10.3177/jnsv.42.233
---------- VANCOUVER ----------
Boccio, J.R., Zubillaga, M.B., Caro, R.A., Gotelli, C.A., Gotelli, M.J., Weill, R. Bioavailability and stability of microencapsulated ferrous sulfate in fluid milk: Studies in mice. J. Nutr. Sci. Vitaminol. 1996;42(3):233-239.http://dx.doi.org/10.3177/jnsv.42.233
