Artículo

García-Tornadu, I.; Risso, G.; Perez-Millan, M.I.; Noain, D.; Diaz-Torga, G.; Low, M.J.; Rubinstein, M.; Becu-Villalobos, D.; Artz E.; Bronstein; Guitelman M. "Neurotransmitter modulation of the GHRH-GH axis" (2010) Frontiers of Hormone Research. 38:59-69
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Abstract:

The role of dopaminergic receptors in the control of GH release remains controversial. The dopamine receptor 2 (D2R) knockout mouse represents a useful model to study the participation of the D2R on growth and GHRH-GH regulation. These knockout mice have hyperprolactinemia and lactotrope hyperplasia, but unexpectedly, they are also growth retarded. In D2R knockout mice there is a significant decrease in somatotrope population, which is paralleled by decreased GH content and output from pituitary cells. The sensitivity of GHRH-induced GH and cAMP release is similar between genotypes, even though the response amplitude is lower in knockouts. We point to an involvement of D2R signaling at the hypothalamic level as dopamine did not release GH acting at the pituitary level, and both somatostatin and GHRH mRNA expression are altered in knockout mice. The similarity of the pituitary defect in the D2R knockout mouse to that of GHRH deficient models suggests a probable mechanism. Loss of dopamine signaling via hypothalamic D2Rs at a critical age may causeinadequate GHRH secretion subsequently leading to inappropriate somatotrope lineage development. Furthermore, GH pulsatility, which depends on a regulated temporal balance between GHRH and somatostatin output might be compromised in D2R knockout mice, leading to lower IGF-I, and growth retardation. Copyright © 2010 S. Karger AG, Basel.

Registro:

Documento: Artículo
Título:Neurotransmitter modulation of the GHRH-GH axis
Autor:García-Tornadu, I.; Risso, G.; Perez-Millan, M.I.; Noain, D.; Diaz-Torga, G.; Low, M.J.; Rubinstein, M.; Becu-Villalobos, D.; Artz E.; Bronstein; Guitelman M.
Filiación:Instituto de Biología y Medicina Experimental, CONICET, Vuelta de Obligado 2490, Buenos Aires 1428, Argentina
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, CONICET, University of Buenos Aires, Buenos Aires, Argentina
Center for the Study of Weight Regulation, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United States
Palabras clave:cyclic AMP; dopamine 2 receptor; growth hormone; growth hormone releasing factor; levodopa; messenger RNA; neurotransmitter; prolactin; somatostatin; acromegaly; dopamine release; genotype; growth hormone deficiency; growth hormone release; human; hyperprolactinemia; hypophysis cell; hypothalamus; knockout mouse; nonhuman; priority journal; protein expression; review; Acromegaly; Animals; Dopamine; Growth; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Mice; Neurotransmitter Agents; Receptors, Dopamine D2
Año:2010
Volumen:38
Página de inicio:59
Página de fin:69
DOI: http://dx.doi.org/10.1159/000318495
Título revista:Frontiers of Hormone Research
Título revista abreviado:Front. Horm. Res.
ISSN:03013073
CAS:cyclic AMP, 60-92-4; growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; growth hormone releasing factor, 83930-13-6, 9034-39-3; levodopa, 59-92-7; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; somatostatin, 38916-34-6, 51110-01-1; Growth Hormone, 9002-72-6; Growth Hormone-Releasing Hormone, 9034-39-3; Neurotransmitter Agents; Receptors, Dopamine D2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03013073_v38_n_p59_GarciaTornadu

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Citas:

---------- APA ----------
García-Tornadu, I., Risso, G., Perez-Millan, M.I., Noain, D., Diaz-Torga, G., Low, M.J., Rubinstein, M.,..., Guitelman M. (2010) . Neurotransmitter modulation of the GHRH-GH axis. Frontiers of Hormone Research, 38, 59-69.
http://dx.doi.org/10.1159/000318495
---------- CHICAGO ----------
García-Tornadu, I., Risso, G., Perez-Millan, M.I., Noain, D., Diaz-Torga, G., Low, M.J., et al. "Neurotransmitter modulation of the GHRH-GH axis" . Frontiers of Hormone Research 38 (2010) : 59-69.
http://dx.doi.org/10.1159/000318495
---------- MLA ----------
García-Tornadu, I., Risso, G., Perez-Millan, M.I., Noain, D., Diaz-Torga, G., Low, M.J., et al. "Neurotransmitter modulation of the GHRH-GH axis" . Frontiers of Hormone Research, vol. 38, 2010, pp. 59-69.
http://dx.doi.org/10.1159/000318495
---------- VANCOUVER ----------
García-Tornadu, I., Risso, G., Perez-Millan, M.I., Noain, D., Diaz-Torga, G., Low, M.J., et al. Neurotransmitter modulation of the GHRH-GH axis. Front. Horm. Res. 2010;38:59-69.
http://dx.doi.org/10.1159/000318495