Abstract:
Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion and growth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has been shown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process in adenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein, RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathways involved in angiogenic and tumorigenic processes (NF-κB/IκB and HIF-1α pathways). Thus, it could have an important role in the development of the pituitary tumors. Copyright © 2010 S. Karger AG, Basel.
Registro:
Documento: |
Artículo
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Título: | Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology |
Autor: | Fuertes, M.; Gerez, J.; Haedo, M.; Giacomini, D.; Páez-Pereda, M.; Labeur, M.; Stalla, G.K.; Arzt, E. |
Filiación: | Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología y Biología Molecular y Celular, Universidad de Buenos Aires, Buenos Aires, Argentina Affectis Pharmaceuticals, Munich, Germany Max Planck Institute of Psychiatry, Munich, Germany Laboratorio de Fisiología y Biología Molecular, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
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Palabras clave: | cytokine; glycoprotein gp 130; hypoxia inducible factor 1; I kappa B; interleukin 6; messenger RNA; angiogenesis; carcinogenesis; clone; cytology; gene overexpression; hormone release; human; hypophysis adenoma; hypophysis tumor; hypoxia; priority journal; protein function; review; Animals; Cytokine Receptor gp130; Gene Expression Profiling; Humans; Interleukin-6; Pituitary Neoplasms; Transcription Factors |
Año: | 2010
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Volumen: | 38
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Página de inicio: | 1
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Página de fin: | 6
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DOI: |
http://dx.doi.org/10.1159/000318488 |
Título revista: | Frontiers of Hormone Research
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Título revista abreviado: | Front. Horm. Res.
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ISSN: | 03013073
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CAS: | Cytokine Receptor gp130, 133483-10-0; Interleukin-6; RSUME protein, human; Transcription Factors
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03013073_v38_n_p1_Fuertes |
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Citas:
---------- APA ----------
Fuertes, M., Gerez, J., Haedo, M., Giacomini, D., Páez-Pereda, M., Labeur, M., Stalla, G.K.,..., Arzt, E.
(2010)
. Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology. Frontiers of Hormone Research, 38, 1-6.
http://dx.doi.org/10.1159/000318488---------- CHICAGO ----------
Fuertes, M., Gerez, J., Haedo, M., Giacomini, D., Páez-Pereda, M., Labeur, M., et al.
"Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology"
. Frontiers of Hormone Research 38
(2010) : 1-6.
http://dx.doi.org/10.1159/000318488---------- MLA ----------
Fuertes, M., Gerez, J., Haedo, M., Giacomini, D., Páez-Pereda, M., Labeur, M., et al.
"Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology"
. Frontiers of Hormone Research, vol. 38, 2010, pp. 1-6.
http://dx.doi.org/10.1159/000318488---------- VANCOUVER ----------
Fuertes, M., Gerez, J., Haedo, M., Giacomini, D., Páez-Pereda, M., Labeur, M., et al. Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology. Front. Horm. Res. 2010;38:1-6.
http://dx.doi.org/10.1159/000318488