Abstract:
Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-β (TGF-β) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. SMAD proteins activated by growth factors of the TGF-β and BMP family interact with estrogen receptors to stimulate the proliferation of prolactin and growth hormone-secreting cells. Furthermore, BMP-4 presents differential expression in normal and adenomatous corticotropes and inhibitory action on corticotropinoma cell proliferation. Moreover, BMP-4 mediates the antiproliferative action of retinoic acid in these cells. The present review highlights not only the crucial and opposite role of BMP-4 in the progression of pituitary adenomas but also that BMP-4 and retinoic acid interaction might serve as a potential new mechanism target for therapeutic approaches for Cushing disease. Copyright © 2006 S. Karger AG.
Registro:
Documento: |
Artículo
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Título: | Bone morphogenetic protein-4 control of pituitary pathophysiology |
Autor: | Giacomini, D.; Páez-Pereda, M.; Theodoropoulou, M.; Gerez, J.; Nagashima, A.C.; Chervin, A.; Berner, S.; Labeur, M.; Refojo, D.; Renner, U.; Stalla, G.K.; Arzt, E. |
Filiación: | Laboratorio de Fisiología Y Biología Molecular, Departamento de Fisiología, Biología Molecular Y Celular, Universidad de Buenos Aires, Buenos Aires, Argentina Max-Planck Institute of Psychiatry, Munich, Germany Affectis Pharmaceuticals, Munich, Germany Department of Neurosurgery and Neuroendocrinology, Hospital Santa Lucía, Buenos Aires, Argentina Laboratorio Fisiología Y Biología Molecular, Depaptamento de Fisiología Y Biología Molecular Y Celular, Pabellon II, 1428 Buenos Aires, Argentina
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Palabras clave: | bone morphogenetic protein; bone morphogenetic protein 4; corticotropin; retinoic acid; transforming growth factor beta; transforming growth factor beta receptor; animal; biological model; conference paper; cytology; gene expression; growth, development and aging; human; hypophysis; hypophysis disease; metabolism; nerve cell; physiology; secretion; Adrenocorticotropic Hormone; Animals; Bone Morphogenetic Proteins; Gene Expression; Humans; Models, Biological; Neurons; Pituitary Diseases; Pituitary Gland; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta; Tretinoin |
Año: | 2006
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Volumen: | 35
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Página de inicio: | 22
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Página de fin: | 31
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DOI: |
http://dx.doi.org/10.1159/000094262 |
Título revista: | Frontiers of Hormone Research
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Título revista abreviado: | Front. Horm. Res.
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ISSN: | 03013073
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CAS: | corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; retinoic acid, 302-79-4; Adrenocorticotropic Hormone, 9002-60-2; bone morphogenetic protein 4; Bone Morphogenetic Proteins; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta; Tretinoin, 302-79-4
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03013073_v35_n_p22_Giacomini |
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Citas:
---------- APA ----------
Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A.C., Chervin, A., Berner, S.,..., Arzt, E.
(2006)
. Bone morphogenetic protein-4 control of pituitary pathophysiology. Frontiers of Hormone Research, 35, 22-31.
http://dx.doi.org/10.1159/000094262---------- CHICAGO ----------
Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A.C., Chervin, A., et al.
"Bone morphogenetic protein-4 control of pituitary pathophysiology"
. Frontiers of Hormone Research 35
(2006) : 22-31.
http://dx.doi.org/10.1159/000094262---------- MLA ----------
Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A.C., Chervin, A., et al.
"Bone morphogenetic protein-4 control of pituitary pathophysiology"
. Frontiers of Hormone Research, vol. 35, 2006, pp. 22-31.
http://dx.doi.org/10.1159/000094262---------- VANCOUVER ----------
Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A.C., Chervin, A., et al. Bone morphogenetic protein-4 control of pituitary pathophysiology. Front. Horm. Res. 2006;35:22-31.
http://dx.doi.org/10.1159/000094262