Artículo

Giacomini, D.; Páez-Pereda, M.; Theodoropoulou, M.; Gerez, J.; Nagashima, A.C.; Chervin, A.; Berner, S.; Labeur, M.; Refojo, D.; Renner, U.; Stalla, G.K.; Arzt, E. "Bone morphogenetic protein-4 control of pituitary pathophysiology" (2006) Frontiers of Hormone Research. 35:22-31
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Abstract:

Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-β (TGF-β) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. SMAD proteins activated by growth factors of the TGF-β and BMP family interact with estrogen receptors to stimulate the proliferation of prolactin and growth hormone-secreting cells. Furthermore, BMP-4 presents differential expression in normal and adenomatous corticotropes and inhibitory action on corticotropinoma cell proliferation. Moreover, BMP-4 mediates the antiproliferative action of retinoic acid in these cells. The present review highlights not only the crucial and opposite role of BMP-4 in the progression of pituitary adenomas but also that BMP-4 and retinoic acid interaction might serve as a potential new mechanism target for therapeutic approaches for Cushing disease. Copyright © 2006 S. Karger AG.

Registro:

Documento: Artículo
Título:Bone morphogenetic protein-4 control of pituitary pathophysiology
Autor:Giacomini, D.; Páez-Pereda, M.; Theodoropoulou, M.; Gerez, J.; Nagashima, A.C.; Chervin, A.; Berner, S.; Labeur, M.; Refojo, D.; Renner, U.; Stalla, G.K.; Arzt, E.
Filiación:Laboratorio de Fisiología Y Biología Molecular, Departamento de Fisiología, Biología Molecular Y Celular, Universidad de Buenos Aires, Buenos Aires, Argentina
Max-Planck Institute of Psychiatry, Munich, Germany
Affectis Pharmaceuticals, Munich, Germany
Department of Neurosurgery and Neuroendocrinology, Hospital Santa Lucía, Buenos Aires, Argentina
Laboratorio Fisiología Y Biología Molecular, Depaptamento de Fisiología Y Biología Molecular Y Celular, Pabellon II, 1428 Buenos Aires, Argentina
Palabras clave:bone morphogenetic protein; bone morphogenetic protein 4; corticotropin; retinoic acid; transforming growth factor beta; transforming growth factor beta receptor; animal; biological model; conference paper; cytology; gene expression; growth, development and aging; human; hypophysis; hypophysis disease; metabolism; nerve cell; physiology; secretion; Adrenocorticotropic Hormone; Animals; Bone Morphogenetic Proteins; Gene Expression; Humans; Models, Biological; Neurons; Pituitary Diseases; Pituitary Gland; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta; Tretinoin
Año:2006
Volumen:35
Página de inicio:22
Página de fin:31
DOI: http://dx.doi.org/10.1159/000094262
Título revista:Frontiers of Hormone Research
Título revista abreviado:Front. Horm. Res.
ISSN:03013073
CAS:corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; retinoic acid, 302-79-4; Adrenocorticotropic Hormone, 9002-60-2; bone morphogenetic protein 4; Bone Morphogenetic Proteins; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta; Tretinoin, 302-79-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03013073_v35_n_p22_Giacomini

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Citas:

---------- APA ----------
Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A.C., Chervin, A., Berner, S.,..., Arzt, E. (2006) . Bone morphogenetic protein-4 control of pituitary pathophysiology. Frontiers of Hormone Research, 35, 22-31.
http://dx.doi.org/10.1159/000094262
---------- CHICAGO ----------
Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A.C., Chervin, A., et al. "Bone morphogenetic protein-4 control of pituitary pathophysiology" . Frontiers of Hormone Research 35 (2006) : 22-31.
http://dx.doi.org/10.1159/000094262
---------- MLA ----------
Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A.C., Chervin, A., et al. "Bone morphogenetic protein-4 control of pituitary pathophysiology" . Frontiers of Hormone Research, vol. 35, 2006, pp. 22-31.
http://dx.doi.org/10.1159/000094262
---------- VANCOUVER ----------
Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A.C., Chervin, A., et al. Bone morphogenetic protein-4 control of pituitary pathophysiology. Front. Horm. Res. 2006;35:22-31.
http://dx.doi.org/10.1159/000094262