Artículo

De Nicola, A.F.; Saravia, F.E.; Beauquis, J.; Pietranera, L.; Ferrini, M.G.; Arzt E.; Guitelman M; Bronstein M. "Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function" (2006) Frontiers of Hormone Research. 35:157-168
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Abstract:

The function of the HPA axis is subject to regulation by many factors, which achieve relevance under normal and pathological conditions. In the case of aging, this period of life is associated with disturbances of the HPA axis and signs of hippocampal vulnerability. We examined 20-month-old male rats, in which abnormalities of the HPA axis included altered response to stress, reduced effectiveness of the steroid negative feedback and low expression of hippocampal glucocorticoid receptors (GR). Estrogen treatment of aging rats normalized the response to stress, restored the dexamethasone inhibition of the stress response and increased GR density in defined hippocampal areas. Although estrogens could influence the hippocampus of aging animals directly, their effects could be also mediated by estrogen-sensitive forebrain cholinergic neurons projecting to the hippocampus. Additionally, estrogens normalized the deficient granule cell proliferation that aging mice present in the dentate gyrus, and attenuated several markers of hippocampal aging, such as astrocytosis, high lipofucsin content and neuronal loss in the hilus of the dentate gyrus. These effects may be important for the regulation of the HPA axis, in the context that hippocampal function as a whole was normalized by estrogen action. Therefore, estrogens are powerful neuroprotectants in cases of hippocampal dysfunction, and as part of this effect, they contribute to stabilize the function of the HPA axis. Copyright © 2006 S. Karger AG.

Registro:

Documento: Artículo
Título:Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function
Autor:De Nicola, A.F.; Saravia, F.E.; Beauquis, J.; Pietranera, L.; Ferrini, M.G.; Arzt E.; Guitelman M; Bronstein M.
Filiación:Laboratory of Neuroendocrine Biochemisty, Instituto de Biología Y Medicina Experimental, Buenos Aires, Argentina
Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
Research and Education Institute, Harbor-UCLA Medical Center, Urology, Torrance, CA, United States
Instituto de Biología Y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:estrogen; steroid; adrenal gland; aging; animal; cholinergic nerve; conference paper; drug effect; feedback system; forebrain; hippocampus; human; hypophysis adrenal system; hypothalamus hypophysis system; metabolism; neurosecretion; physiology; rat; Adrenal Glands; Aging; Animals; Cholinergic Fibers; Estrogens; Feedback, Biochemical; Hippocampus; Humans; Hypothalamo-Hypophyseal System; Neurosecretory Systems; Pituitary-Adrenal System; Prosencephalon; Rats; Steroids
Año:2006
Volumen:35
Página de inicio:157
Página de fin:168
DOI: http://dx.doi.org/10.1159/000094324
Título revista:Frontiers of Hormone Research
Título revista abreviado:Front. Horm. Res.
ISSN:03013073
CAS:Estrogens; Steroids
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03013073_v35_n_p157_DeNicola

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Citas:

---------- APA ----------
De Nicola, A.F., Saravia, F.E., Beauquis, J., Pietranera, L., Ferrini, M.G., Arzt E., Guitelman M,..., Bronstein M. (2006) . Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function. Frontiers of Hormone Research, 35, 157-168.
http://dx.doi.org/10.1159/000094324
---------- CHICAGO ----------
De Nicola, A.F., Saravia, F.E., Beauquis, J., Pietranera, L., Ferrini, M.G., Arzt E., et al. "Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function" . Frontiers of Hormone Research 35 (2006) : 157-168.
http://dx.doi.org/10.1159/000094324
---------- MLA ----------
De Nicola, A.F., Saravia, F.E., Beauquis, J., Pietranera, L., Ferrini, M.G., Arzt E., et al. "Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function" . Frontiers of Hormone Research, vol. 35, 2006, pp. 157-168.
http://dx.doi.org/10.1159/000094324
---------- VANCOUVER ----------
De Nicola, A.F., Saravia, F.E., Beauquis, J., Pietranera, L., Ferrini, M.G., Arzt E., et al. Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function. Front. Horm. Res. 2006;35:157-168.
http://dx.doi.org/10.1159/000094324