Abstract:
Testosterone administration to orchidectomized rats brought about a significant, 55% decrease of β-adrenoceptor sites in the pineal gland, assessed from the specific binding of radioactive dihydroalprenolol (DHA). The changes in density of binding sites were not accompanied by significant modifications of the Kd. FSH or LH treatment of acutely castrated animals did not affect pineal β-adrenoceptor binding. The depressive effects of testosterone in β-adrenergic receptors were also observed in crude membrane fractions of medial basal hypothalamus and cerebral cortex. Sympathetic denervation of the pineal gland by superior cervical ganglionectomy did not abolish the changes in pineal β-adrenoceptor density caused by testosterone. Hormone effects did not depend on a direct effect of the hormone on β-adrenoceptor sites because testosterone did not compete with [3H]-DHA for the binding sites, in vitro. These results suggest that testosterone depresses pineal β-adrenergic sites by acting mainly on post-synaptic sites. © 1982 Springer-Verlag.
Registro:
Documento: |
Artículo
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Título: | Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain |
Autor: | Vacas, M.I.; Lowenstein, P.R.; Cardinali, D.P. |
Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Buenos Aires, Argentina
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Palabras clave: | β-adrenoceptors; FSH; LH; Pineal; superior cervical ganglion; testosterone; androstanolone; beta adrenergic receptor; drug receptor; follitropin; luteinizing hormone; propranolol; radioisotope; testosterone; animal experiment; brain; central nervous system; dihydroalprenolol h 3; endocrine system; pineal body; rat; Animal; Brain; Castration; Dihydroalprenolol; Female; Kinetics; Male; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Support, Non-U.S. Gov't; Testosterone |
Año: | 1982
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Volumen: | 53
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Número: | 1
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Página de inicio: | 49
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Página de fin: | 57
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DOI: |
http://dx.doi.org/10.1007/BF01243519 |
Título revista: | Journal of Neural Transmission
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Título revista abreviado: | J. Neural Transmission
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ISSN: | 03009564
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CODEN: | JNTRF
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CAS: | androstanolone, 521-18-6; follitropin, 9002-68-0; luteinizing hormone, 39341-83-8, 9002-67-9; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; testosterone, 58-22-0; Dihydroalprenolol, 60106-89-0; Receptors, Adrenergic; Receptors, Adrenergic, beta; Testosterone, 57-85-2
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v53_n1_p49_Vacas |
Referencias:
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Citas:
---------- APA ----------
Vacas, M.I., Lowenstein, P.R. & Cardinali, D.P.
(1982)
. Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain. Journal of Neural Transmission, 53(1), 49-57.
http://dx.doi.org/10.1007/BF01243519---------- CHICAGO ----------
Vacas, M.I., Lowenstein, P.R., Cardinali, D.P.
"Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain"
. Journal of Neural Transmission 53, no. 1
(1982) : 49-57.
http://dx.doi.org/10.1007/BF01243519---------- MLA ----------
Vacas, M.I., Lowenstein, P.R., Cardinali, D.P.
"Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain"
. Journal of Neural Transmission, vol. 53, no. 1, 1982, pp. 49-57.
http://dx.doi.org/10.1007/BF01243519---------- VANCOUVER ----------
Vacas, M.I., Lowenstein, P.R., Cardinali, D.P. Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain. J. Neural Transmission. 1982;53(1):49-57.
http://dx.doi.org/10.1007/BF01243519