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Abstract:

The effects of FSH and LH on norepinephrine (NE) turnover in pineal gland and superior cervical ganglia of castrated female rats were examined by measuring the decline of [3H]NE concentration in the organ 30-120 min after a single i.v. injection of the labeled amine. Both FSH and LH treatment significantly decreased [3H]NE turnover in the pineal gland whereas only FSH accelerated it in the ganglia. As compared to controls, the initial uptake of [3H]NE was lower in the pineal gland of FSH- and LH-treated animals, and higher in the superior cervical ganglia of rats injected with FSH. Neither FSH nor LH modified [3H]NE turnover in heart or adrenal gland, nor changed their endogenous catecholamine content. Pineal monoamine oxidase (MAO) activity type B (assaying by using β-phenylethylamine as substrate) was decreased by FSH or LH injection. Only FSH modified MAO activity in the ganglia by increasing significantly type A enzyme (assaying by using serotonin as substrate). These results suggest that FSH and LH affect significantly NE metabolism in pineal gland and superior cervical ganglia of spayed rats. © 1979 Springer-Verlag.

Registro:

Documento: Artículo
Título:Norepinephrine turnover in pineal gland and superior cervical ganglia. Changes after gonadotrophin administration to castrated rats
Autor:Cardinali, D.P.; Vacas, M.I.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina
Palabras clave:FSH; LH; norepinephrine metabolism; pineal gland; superior cervical ganglion; estradiol; follitropin; luteinizing hormone; noradrenalin; testosterone; animal experiment; autonomic nervous system; castration; endocrine system; noradrenalin h 3; phenethylamine c 14; pineal body; rat; serotonin c 14; superior cervical ganglion; Adrenal Glands; Animal; Castration; Female; Follicle Stimulating Hormone; Ganglia, Sympathetic; Luteinizing Hormone; Monoamine Oxidase; Myocardium; Phenethylamines; Pineal Gland; Rats; Serotonin
Año:1979
Volumen:45
Número:4
Página de inicio:273
Página de fin:284
DOI: http://dx.doi.org/10.1007/BF01247144
Título revista:Journal of Neural Transmission
Título revista abreviado:J. Neural Transmission
ISSN:03009564
CODEN:JNTRF
CAS:estradiol, 50-28-2; follitropin, 9002-68-0; luteinizing hormone, 39341-83-8, 9002-67-9; noradrenalin, 1407-84-7, 51-41-2; testosterone, 58-22-0; Follicle Stimulating Hormone, 9002-68-0; Luteinizing Hormone, 9002-67-9; Monoamine Oxidase, EC 1.4.3.4; Phenethylamines; Serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v45_n4_p273_Cardinali

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Citas:

---------- APA ----------
Cardinali, D.P. & Vacas, M.I. (1979) . Norepinephrine turnover in pineal gland and superior cervical ganglia. Changes after gonadotrophin administration to castrated rats. Journal of Neural Transmission, 45(4), 273-284.
http://dx.doi.org/10.1007/BF01247144
---------- CHICAGO ----------
Cardinali, D.P., Vacas, M.I. "Norepinephrine turnover in pineal gland and superior cervical ganglia. Changes after gonadotrophin administration to castrated rats" . Journal of Neural Transmission 45, no. 4 (1979) : 273-284.
http://dx.doi.org/10.1007/BF01247144
---------- MLA ----------
Cardinali, D.P., Vacas, M.I. "Norepinephrine turnover in pineal gland and superior cervical ganglia. Changes after gonadotrophin administration to castrated rats" . Journal of Neural Transmission, vol. 45, no. 4, 1979, pp. 273-284.
http://dx.doi.org/10.1007/BF01247144
---------- VANCOUVER ----------
Cardinali, D.P., Vacas, M.I. Norepinephrine turnover in pineal gland and superior cervical ganglia. Changes after gonadotrophin administration to castrated rats. J. Neural Transmission. 1979;45(4):273-284.
http://dx.doi.org/10.1007/BF01247144