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Abstract:

This brief review resolves a number of persistent conflicts regarding the location and characteristics of the mesencephalic locomotor region, which has in the past been described as not locomotion-specific and is more likely the pedunculopontine nucleus (PPN). The parameters of stimulation used to elicit changes in posture and locomotion we now know are ideally suited to match the intrinsic membrane properties of PPN neurons. The physiology of these cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for the treatment of gait and postural deficits in Parkinson’s disease (PD). The discussion explains many of the effects reported following deep brain stimulation (DBS) of the PPN by different groups and provides guidelines for the determination of long-term assessment and effects of PPN DBS. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from DBS for movement disorders. Despite these improvements, there remains a great opportunity for further understanding of the mechanisms through which DBS has its effects and for further development of appropriate technology to effect these treatments. We review the scientific basis for one of the newest targets, the PPN, in the treatment of PD and other movement disorders, and address the needs for further investigation. © 2014, Springer-Verlag Wien.

Registro:

Documento: Artículo
Título:The physiology of the pedunculopontine nucleus: implications for deep brain stimulation
Autor:Garcia-Rill, E.; Hyde, J.; Kezunovic, N.; Urbano, F.J.; Petersen, E.
Filiación:Department of Neurobiology and Developmental Sciences, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Slot 847, 4301 West Markham St, Little Rock, AR 72205, United States
Department of Neurosurgery, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States
IFIBYNE-CONICET, University of Buenos Aires, Buenos Aires, Argentina
Palabras clave:Calcium channels; Deep brain stimulation; Pedunculopontine nucleus; Reticular activating system; animal; brain depth stimulation; human; Movement Disorders; pedunculopontine tegmental nucleus; physiology; Animals; Deep Brain Stimulation; Humans; Movement Disorders; Pedunculopontine Tegmental Nucleus
Año:2015
Volumen:122
Número:2
Página de inicio:225
Página de fin:235
DOI: http://dx.doi.org/10.1007/s00702-014-1243-x
Título revista:Journal of Neural Transmission
Título revista abreviado:J. Neural Transm.
ISSN:03009564
CODEN:JNTRF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v122_n2_p225_GarciaRill

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Citas:

---------- APA ----------
Garcia-Rill, E., Hyde, J., Kezunovic, N., Urbano, F.J. & Petersen, E. (2015) . The physiology of the pedunculopontine nucleus: implications for deep brain stimulation. Journal of Neural Transmission, 122(2), 225-235.
http://dx.doi.org/10.1007/s00702-014-1243-x
---------- CHICAGO ----------
Garcia-Rill, E., Hyde, J., Kezunovic, N., Urbano, F.J., Petersen, E. "The physiology of the pedunculopontine nucleus: implications for deep brain stimulation" . Journal of Neural Transmission 122, no. 2 (2015) : 225-235.
http://dx.doi.org/10.1007/s00702-014-1243-x
---------- MLA ----------
Garcia-Rill, E., Hyde, J., Kezunovic, N., Urbano, F.J., Petersen, E. "The physiology of the pedunculopontine nucleus: implications for deep brain stimulation" . Journal of Neural Transmission, vol. 122, no. 2, 2015, pp. 225-235.
http://dx.doi.org/10.1007/s00702-014-1243-x
---------- VANCOUVER ----------
Garcia-Rill, E., Hyde, J., Kezunovic, N., Urbano, F.J., Petersen, E. The physiology of the pedunculopontine nucleus: implications for deep brain stimulation. J. Neural Transm. 2015;122(2):225-235.
http://dx.doi.org/10.1007/s00702-014-1243-x