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Beck, P.; Urbano, F.J.; Williams, D.K.; Garcia-Rill, E. "Effects of leptin on pedunculopontine nucleus (PPN) neurons" (2013) Journal of Neural Transmission. 120(7):1027-1038
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Abstract:

Leptin, a hormone that regulates appetite and energy expenditure, is increased in obese individuals, although these individuals often exhibit leptin resistance. Obesity is characterized by sleep/wake disturbances, such as excessive daytime sleepiness, increased REM sleep, increased nighttime arousals, and decreased percentage of total sleep time. Several studies have shown that short sleep duration is highly correlated with decreased leptin levels in both animal and human models. Arousal and rapid eye movement (REM) sleep are regulated by the cholinergic arm of the reticular activating system, the pedunculopontine nucleus (PPN). The goal of this project was to determine the role of leptin in the PPN, and thus in obesity-related sleep disorders. Whole-cell patch-clamp recordings were conducted on PPN neurons in 9- to 17-day-old rat brainstem slices. Leptin decreased action potential (AP) amplitude, AP frequency, and h-current (I H). These findings suggest that leptin causes a blockade of Na+ channels. Therefore, we conducted an experiment to test the effects of leptin on Na+ conductance. To determine the average voltage dependence of this conductance, results from each cell were equally weighted by expressing conductance as a fraction of the maximum conductance in each cell. I Na amplitude was decreased in a dose-dependent manner, suggesting a direct effect of leptin on these channels. The average decrease in Na+ conductance by leptin was ~40 %. We hypothesize that leptin normally decreases activity in the PPN by reducing I H and I Na currents, and that in states of leptin dysregulation (i.e., leptin resistance) this effect may be blunted, therefore causing increased arousal and REM sleep drive, and ultimately leading to sleep-related disorders. © 2012 Springer-Verlag Wien.

Registro:

Documento: Artículo
Título:Effects of leptin on pedunculopontine nucleus (PPN) neurons
Autor:Beck, P.; Urbano, F.J.; Williams, D.K.; Garcia-Rill, E.
Filiación:Department of Neurobiology and Developmental Sciences, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, Little Rock, AR 72205, United States
IFIBYNE, CONICET, University of Buenos Aires Ciudad Universitaria, Pabellon 2, Piso 2 (C14228EHA), Buenos Aires, Argentina
Palabras clave:Arousal; Hyperpolarization-activated cation current; Sodium current; leptin; agents interacting with transmitter, hormone or drug receptors; ion channel; leptin; action potential; animal cell; arousal; article; controlled study; nerve cell; newborn; nonhuman; patch clamp; pedunculopontine tegmental nucleus; priority journal; rat; REM sleep; sleep disorder; sodium conductance; sodium current; animal; biophysics; channel gating; cytology; dose response; drug effects; electrostimulation; female; in vitro study; male; nerve cell; nonparametric test; patch clamp technique; pedunculopontine tegmental nucleus; physiology; pregnancy; Sprague Dawley rat; Action Potentials; Animals; Animals, Newborn; Biophysical Processes; Biophysics; Dose-Response Relationship, Drug; Electric Stimulation; Female; In Vitro Techniques; Ion Channel Gating; Ion Channels; Leptin; Male; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Pedunculopontine Tegmental Nucleus; Pregnancy; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric
Año:2013
Volumen:120
Número:7
Página de inicio:1027
Página de fin:1038
DOI: http://dx.doi.org/10.1007/s00702-012-0957-x
Título revista:Journal of Neural Transmission
Título revista abreviado:J. Neural Transm.
ISSN:03009564
CODEN:JNTRF
CAS:Ion Channels; Leptin; Neurotransmitter Agents
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v120_n7_p1027_Beck

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Citas:

---------- APA ----------
Beck, P., Urbano, F.J., Williams, D.K. & Garcia-Rill, E. (2013) . Effects of leptin on pedunculopontine nucleus (PPN) neurons. Journal of Neural Transmission, 120(7), 1027-1038.
http://dx.doi.org/10.1007/s00702-012-0957-x
---------- CHICAGO ----------
Beck, P., Urbano, F.J., Williams, D.K., Garcia-Rill, E. "Effects of leptin on pedunculopontine nucleus (PPN) neurons" . Journal of Neural Transmission 120, no. 7 (2013) : 1027-1038.
http://dx.doi.org/10.1007/s00702-012-0957-x
---------- MLA ----------
Beck, P., Urbano, F.J., Williams, D.K., Garcia-Rill, E. "Effects of leptin on pedunculopontine nucleus (PPN) neurons" . Journal of Neural Transmission, vol. 120, no. 7, 2013, pp. 1027-1038.
http://dx.doi.org/10.1007/s00702-012-0957-x
---------- VANCOUVER ----------
Beck, P., Urbano, F.J., Williams, D.K., Garcia-Rill, E. Effects of leptin on pedunculopontine nucleus (PPN) neurons. J. Neural Transm. 2013;120(7):1027-1038.
http://dx.doi.org/10.1007/s00702-012-0957-x