Artículo

Domínguez, R.O.; Marschoff, E.R.; Guareschi, E.M.; Repetto, M.G.; Famulari, A.L.; Pagano, M.A.; Serra, J.A.; Bartolomé, E.L.; González, S.; D'Abraccio, G.; Arata, M.; Oudkerk, L.; Garau, L.; Krinsky, F.; Labos, E.; Ruiz, C.; Frechtel, G.; Arana, A.; Lovecchio, S. "Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition" (2008) Journal of Neural Transmission. 115(1):77-84
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Abstract:

Increased concentrations of insulin, glucose and glycohemoglobin are associated with Type II diabetes mellitus (DM) and recognized as characteristic markers of the disease; in Alzheimer's (AD), Vascular dementia (VaD), and both dementia's with superimposed diabetes (AD + DM, VaD + DM) the knowledge is scarce. The sample (n = 122; males = 60; mean age = 73 ± 7) comprised DM, AD, VaD, AD + DM, and VaD + DM patients, and healthy controls (C). The ANOVA's yielded significant differences between groups: Insulin p = 3.7 × 10 -3; Glucose p < 10-12; Glycohemoglobin p = 9.2×10-4. Comparisons between groups (DM vs. C, AD + DM vs. AD, VaD + DM vs. VaD, and demented DM vs. non-demented DM) resulted significant for all variables (Bonferroni's statistic, α = 0.05). Diabetic and diabetic demented patients presented significant increases largely different from controls (0.01 < p < 0.001), unlike the non-significant changes in their non-diabetic counterparts; linear relationships were found across all groups. The correlation's insulin/glucose and insulin/glycohemoglobin change to positive within demented groups, indicating a different performance of insulin in demented and non-demented subjects. © 2007 Springer-Verlag.

Registro:

Documento: Artículo
Título:Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition
Autor:Domínguez, R.O.; Marschoff, E.R.; Guareschi, E.M.; Repetto, M.G.; Famulari, A.L.; Pagano, M.A.; Serra, J.A.; Bartolomé, E.L.; González, S.; D'Abraccio, G.; Arata, M.; Oudkerk, L.; Garau, L.; Krinsky, F.; Labos, E.; Ruiz, C.; Frechtel, G.; Arana, A.; Lovecchio, S.
Filiación:Facultad de Medicina, Hospital Sirio-Libanés, FACENE, Buenos Aires, Argentina
Facultad de Ciencias Exactas Y Naturales, UBA, Buenos Aires, Argentina
Laboratorio Especializado para Las Investigaciones Clínicas (LEPLIC), Buenos Aires, Argentina
Facultad de Farmacia Y Bioquímica, UBA, Programa de Radicales Libres (PRALIB), Buenos Aires, Argentina
Facultad de Medicina, Hospital Juan A. Fernández, UBA, Buenos Aires, Argentina
Consejo Nac. de Invest. Cientificas Y Tecnicas (CONICET) - Programa de Radicales Libres (PRALIB), Facultad de Farmacia Y Bioquímica, UBA, Buenos Aires, Argentina
Diabetes Unit, Hospital General de Agudos Juan A. Fernández, Hospital Sirio-Libanés
Laboratorio de Estrés Oxidativo, PRALIB-CONICET, UBA, Junín 954, C1113AAD Buenos Aires, Argentina
Palabras clave:Alzheimer's disease; Dementia risk factors; Glucose; Glycated hemoglobin; Insulin; Non-insulin-dependent Type II diabetes mellitus; Vascular dementia; glucose; glycosylated hemoglobin; insulin; aged; Alzheimer disease; analysis of variance; article; comparative study; controlled study; correlation analysis; female; glucose blood level; hemoglobin blood level; human; insulin blood level; major clinical study; male; multiinfarct dementia; non insulin dependent diabetes mellitus; priority journal; statistics; Aged; Alzheimer Disease; Blood Glucose; Brain; Dementia, Vascular; Diabetes Mellitus, Type 2; Female; Hemoglobin A, Glycosylated; Humans; Insulin; Magnetic Resonance Imaging; Male
Año:2008
Volumen:115
Número:1
Página de inicio:77
Página de fin:84
DOI: http://dx.doi.org/10.1007/s00702-007-0804-7
Título revista:Journal of Neural Transmission
Título revista abreviado:J. Neural Transm.
ISSN:03009564
CODEN:JNTRF
CAS:glucose, 50-99-7, 84778-64-3; glycosylated hemoglobin, 9062-63-9; insulin, 9004-10-8; Blood Glucose; Hemoglobin A, Glycosylated; Insulin, 11061-68-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v115_n1_p77_Dominguez

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Citas:

---------- APA ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Repetto, M.G., Famulari, A.L., Pagano, M.A., Serra, J.A.,..., Lovecchio, S. (2008) . Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition. Journal of Neural Transmission, 115(1), 77-84.
http://dx.doi.org/10.1007/s00702-007-0804-7
---------- CHICAGO ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Repetto, M.G., Famulari, A.L., Pagano, M.A., et al. "Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition" . Journal of Neural Transmission 115, no. 1 (2008) : 77-84.
http://dx.doi.org/10.1007/s00702-007-0804-7
---------- MLA ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Repetto, M.G., Famulari, A.L., Pagano, M.A., et al. "Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition" . Journal of Neural Transmission, vol. 115, no. 1, 2008, pp. 77-84.
http://dx.doi.org/10.1007/s00702-007-0804-7
---------- VANCOUVER ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Repetto, M.G., Famulari, A.L., Pagano, M.A., et al. Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition. J. Neural Transm. 2008;115(1):77-84.
http://dx.doi.org/10.1007/s00702-007-0804-7