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Abstract:

Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes; antioxidant capacity (TRAP) in plasma. Biochemical variables were analyzed simultaneously using multivariate and non-parametric methods. Clinical diagnostic resulted associated with the main source of variability in antioxidant variables (Kruskal-Wallis: H = 32.58, p = 0.000001). Comparison of PD and C resulted highly significant (z = 4.47, p = 0.000047), demonstrating an association between oxidative stress and PD. SOD and TBARS were significantly higher in pathological groups against C (p = 0.0000001, p = 0.051); TRAP resulted lower (p = 0.00015). Discriminant functions constructed using biochemical variables separated pathological groups (93% success) from C, and DAT (88.9%) from VD (73.3%); but not PD from DAT or VD. Antioxidant profiles of PD patients showed characteristics overlapping with DAT (60%) and with VD (40%), suggesting biochemical similarities between them.

Registro:

Documento: Artículo
Título:Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients
Autor:Serra, J.A.; Domínguez, R.O.; De Lustig, E.S.; Guareschi, E.M.; Famulari, A.L.; Bartolomé, E.L.; Marschoff, E.R.
Filiación:Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Hospital Sirio - Libanés, FACENE, Buenos Aires, Argentina
Instituto de Oncología Angel H. Roffo (UBA), Buenos Aires, Argentina
Laboratorio Especializado para Las Investigaciones Clínicas (LEPLIC), Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, UBA, Buenos Aires, Argentina
Palabras clave:Antioxidant system; Cu-Zn superoxide dismutase; Dementia of the Alzheimer's type; Oxygen free radicals; Parkinson's disease; Peripheral markers; Vascular dementia; antioxidant; catalase; copper zinc superoxide dismutase; glutathione; thiobarbituric acid reactive substance; Alzheimer disease; antioxidant activity; article; biochemistry; blood analysis; controlled study; disease marker; enzyme assay; erythrocyte level; human; major clinical study; multiinfarct dementia; oxidative stress; Parkinson disease; priority journal; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Antioxidants; Dementia, Vascular; Discriminant Analysis; Female; Humans; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Statistics, Nonparametric
Año:2001
Volumen:108
Número:10
Página de inicio:1135
Página de fin:1148
DOI: http://dx.doi.org/10.1007/s007020170003
Título revista:Journal of Neural Transmission
Título revista abreviado:J. Neural Transm.
ISSN:03009564
CODEN:JNTRF
CAS:Antioxidants
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v108_n10_p1135_Serra

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Citas:

---------- APA ----------
Serra, J.A., Domínguez, R.O., De Lustig, E.S., Guareschi, E.M., Famulari, A.L., Bartolomé, E.L. & Marschoff, E.R. (2001) . Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients. Journal of Neural Transmission, 108(10), 1135-1148.
http://dx.doi.org/10.1007/s007020170003
---------- CHICAGO ----------
Serra, J.A., Domínguez, R.O., De Lustig, E.S., Guareschi, E.M., Famulari, A.L., Bartolomé, E.L., et al. "Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients" . Journal of Neural Transmission 108, no. 10 (2001) : 1135-1148.
http://dx.doi.org/10.1007/s007020170003
---------- MLA ----------
Serra, J.A., Domínguez, R.O., De Lustig, E.S., Guareschi, E.M., Famulari, A.L., Bartolomé, E.L., et al. "Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients" . Journal of Neural Transmission, vol. 108, no. 10, 2001, pp. 1135-1148.
http://dx.doi.org/10.1007/s007020170003
---------- VANCOUVER ----------
Serra, J.A., Domínguez, R.O., De Lustig, E.S., Guareschi, E.M., Famulari, A.L., Bartolomé, E.L., et al. Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients. J. Neural Transm. 2001;108(10):1135-1148.
http://dx.doi.org/10.1007/s007020170003