Abstract:
Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes; antioxidant capacity (TRAP) in plasma. Biochemical variables were analyzed simultaneously using multivariate and non-parametric methods. Clinical diagnostic resulted associated with the main source of variability in antioxidant variables (Kruskal-Wallis: H = 32.58, p = 0.000001). Comparison of PD and C resulted highly significant (z = 4.47, p = 0.000047), demonstrating an association between oxidative stress and PD. SOD and TBARS were significantly higher in pathological groups against C (p = 0.0000001, p = 0.051); TRAP resulted lower (p = 0.00015). Discriminant functions constructed using biochemical variables separated pathological groups (93% success) from C, and DAT (88.9%) from VD (73.3%); but not PD from DAT or VD. Antioxidant profiles of PD patients showed characteristics overlapping with DAT (60%) and with VD (40%), suggesting biochemical similarities between them.
Registro:
Documento: |
Artículo
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Título: | Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients |
Autor: | Serra, J.A.; Domínguez, R.O.; De Lustig, E.S.; Guareschi, E.M.; Famulari, A.L.; Bartolomé, E.L.; Marschoff, E.R. |
Filiación: | Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina Hospital Sirio - Libanés, FACENE, Buenos Aires, Argentina Instituto de Oncología Angel H. Roffo (UBA), Buenos Aires, Argentina Laboratorio Especializado para Las Investigaciones Clínicas (LEPLIC), Buenos Aires, Argentina Facultad de Ciencias Exactas y Naturales, UBA, Buenos Aires, Argentina
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Palabras clave: | Antioxidant system; Cu-Zn superoxide dismutase; Dementia of the Alzheimer's type; Oxygen free radicals; Parkinson's disease; Peripheral markers; Vascular dementia; antioxidant; catalase; copper zinc superoxide dismutase; glutathione; thiobarbituric acid reactive substance; Alzheimer disease; antioxidant activity; article; biochemistry; blood analysis; controlled study; disease marker; enzyme assay; erythrocyte level; human; major clinical study; multiinfarct dementia; oxidative stress; Parkinson disease; priority journal; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Antioxidants; Dementia, Vascular; Discriminant Analysis; Female; Humans; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Statistics, Nonparametric |
Año: | 2001
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Volumen: | 108
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Número: | 10
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Página de inicio: | 1135
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Página de fin: | 1148
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DOI: |
http://dx.doi.org/10.1007/s007020170003 |
Título revista: | Journal of Neural Transmission
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Título revista abreviado: | J. Neural Transm.
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ISSN: | 03009564
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CODEN: | JNTRF
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CAS: | Antioxidants
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v108_n10_p1135_Serra |
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Citas:
---------- APA ----------
Serra, J.A., Domínguez, R.O., De Lustig, E.S., Guareschi, E.M., Famulari, A.L., Bartolomé, E.L. & Marschoff, E.R.
(2001)
. Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients. Journal of Neural Transmission, 108(10), 1135-1148.
http://dx.doi.org/10.1007/s007020170003---------- CHICAGO ----------
Serra, J.A., Domínguez, R.O., De Lustig, E.S., Guareschi, E.M., Famulari, A.L., Bartolomé, E.L., et al.
"Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients"
. Journal of Neural Transmission 108, no. 10
(2001) : 1135-1148.
http://dx.doi.org/10.1007/s007020170003---------- MLA ----------
Serra, J.A., Domínguez, R.O., De Lustig, E.S., Guareschi, E.M., Famulari, A.L., Bartolomé, E.L., et al.
"Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients"
. Journal of Neural Transmission, vol. 108, no. 10, 2001, pp. 1135-1148.
http://dx.doi.org/10.1007/s007020170003---------- VANCOUVER ----------
Serra, J.A., Domínguez, R.O., De Lustig, E.S., Guareschi, E.M., Famulari, A.L., Bartolomé, E.L., et al. Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients. J. Neural Transm. 2001;108(10):1135-1148.
http://dx.doi.org/10.1007/s007020170003