Navegar

Colección

Datos Estadísticas

Artículo

Bia, D.; Zócalo, Y.; Armentano, R.L.; Camus, J.; de Forteza, E.; Cabrera-Fischer, E. "The adventitia reduces left ventricular dynamic afterload via smooth muscle activation-dependent machanisms " (2007) Revista Espanola de Cardiologia. 60(5):501-509
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor

Abstract:

Introduction and objectives. Ventricular dynamic afterload depends on arterial viscoelastic and geometric properties. Vasoactive factors produced in the adventitia modulate arterial tone. However, it is still not known whether the adventitia is involved in determining the magnitude of the dynamic afterload. The aim of this study was to investigate the role played by the adventitia, via smooth muscle-dependent mechanisms, in determining dynamic afterload. Methods. The diameter, pressure and flow in brachiocephalic trunks from sheep were measured before and after removal of the adventitia, both in vivo with muscular reactivity preserved (n=8) and in vitro with muscular reactivity abolished (n=8). All studies were performed under similar hemodynamic conditions. Dynamic afterload was determined from elastic and viscous arterial responses, elastic and viscous work, arterial characteristic impedance, and pulse wave velocity. Comparison of in vivo and in vitro findings enabled smooth muscle-dependent changes to be evaluated. Results. Only in vivo, did removal of the adventitia lead to a reduction in vessel diameter (17.32 [2.02] vs 15.46 [1.28] mm) and to increases in elastic (7.21 [1.39] vs 15.59 [3.00] × 10 6 dyn.cm -2) and viscous (5.16 [2.04] vs 9.87 [2.00] × 10 5 dyn.s.cm -2) arterial responses, elastic (6.15 [1.08] vs 9.20 [0.76] × 10 -2 J/m 2 ) and viscous work (11.61 [2.25] vs 15.20 [2.37] × 10 -3 J/m 2), impedance (223.97 [136.11] vs 396.33 [182.27] dyn · s · cm -3), and pulse wave velocity (397.70 [31.21] vs 598.78 [28.04] cm.s -1) (P<.05). The reduction in diameter and the increases in elastic and viscous responses are evidence of muscular activation. Conclusions. The adventitia may contribute to the control of ventricular dynamic afterload by means of mechanisms dependent on muscular tone.

Registro:

Documento: Artículo
Título:The adventitia reduces left ventricular dynamic afterload via smooth muscle activation-dependent machanisms
Autor:Bia, D.; Zócalo, Y.; Armentano, R.L.; Camus, J.; de Forteza, E.; Cabrera-Fischer, E.
Filiación:Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Gral. Flores, 2125, 11800 Montevideo, Uruguay
Facultad de Ingeniería, Ciencias Exactas y Naturales, Universidad Favaloro, Buenos Aires, Argentina
Idioma: Español
Palabras clave:Adventitia; Arterial impedance; Basic research; Dynamic afterload; Hemodynamics; Physiology; Smooth muscle; Vascular biology; adventitia; animal tissue; arterial pressure; artery blood flow; artery compliance; artery diameter; artery tone; article; brachiocephalic trunk; controlled study; heart afterload; hemodynamic parameters; impedance; in vitro study; in vivo study; mathematical analysis; muscle contractility; muscle tone; nonhuman; pulse wave; sheep; smooth muscle; viscoelasticity; animal; connective tissue; female; heart left ventricle function; physiology; vascular smooth muscle; Animals; Brachiocephalic Trunk; Connective Tissue; Female; Muscle, Smooth, Vascular; Sheep; Ventricular Function, Left
Año:2007
Volumen:60
Número:5
Página de inicio:501
Página de fin:509
Título revista:Revista Espanola de Cardiologia
Título revista abreviado:Rev. Esp. Cardiol.
ISSN:03008932
CODEN:RCDOA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03008932_v60_n5_p501_Bia

Referencias:

  • Nichols, W., O'Rourke, M., Vascular impedance (2005) McDonald's blood flow in arteries: Theoretical, experimental and clinical principles, pp. 233-267. , Nichols W, O'Rourke M, editors, 5th ed. London: Edward Arnold;
  • Bia, D., Barra, J.G., Grignola, J.C., Ginés, F.F., Armentano, R.L., Pulmonary artery smooth muscle activation attenuates arterial dysfunction during acute pulmonary hypertension (2005) J Appl Physiol, 98, pp. 605-613
  • Armentano, R.L., Barra, J.G., Santana, D.B., Pessana, F.M., Graf, S., Craiem, D., Smart damping modulation of carotid wall energetics in human hypertension: Effects of angiotensin-converting enzyme inhibition (2006) Hypertension, 47, pp. 384-390
  • Bia, D., Aguirre, I., Zocalo, Y., Devera, L., Cabrera-Fischer, E., Armentano, R., Regional differences in viscosity, elasticity and wall buffering function in systemic arteries: Pulse wave analysis of the arterial pressure-diameter relationship (2005) Rev Esp Cardiol, 58, pp. 167-174
  • Cabrera-Fischer, E.I., Armentano, R.L., Pessana, F., Graf, S., Romero, L., Christen, A.I., Endothelium-dependent arterial wall tone elasticity modulated by blood viscosity (2002) Am J Physiol Heart Circ Physiol, 282, pp. H389-H394
  • González, M.C., Arribas, S.M., Molero, F., Fernández-Alfonso, M.S., Effect of removal of adventitia on vascular smooth muscle contraction and relaxation (2001) Am J Physiol Heart Circ Physiol, 280, pp. H2876-H2881
  • Gutterman, D.D., Adventitia-dependent influences on vascular function (1999) Am J Physiol Heart Circ Physiol, 277, pp. H1265-H1272
  • Rey, F.E., Pagano, P.J., The reactive adventitia. Fibroblast oxidase in vascular function (2002) Arterioscler Thromb Vasc Biol, 22, pp. 1962-1971
  • Löhn, M., Dubrovska, G., Lauterbach, B., Luft, F.C., Gollasch, M., Sharma, A.M., Periadventitial fat releases a vascular relaxing factor (2002) FASEB, 16, pp. 1057-1063
  • Kurt, R., Stenmark, N.D., Frid, M., Gerasimovskaya, E., Das, M., Role of the adventitia in pulmonary vascular remodeling (2006) Physiology, 21, pp. 134-145
  • Verlohren, S., Dubrovska, G., Tsang, S.Y., Essin, K., Luft, F.C., Huang, Y., Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries (2004) Hypertension, 44, pp. 271-276
  • Hu, Y., Zhang, Z., Torsney, E., Afzal, A.R., Davison, F., Metzler, B., Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice (2004) J Clin Invest, 113, pp. 1258-1265
  • Schulze-Bauer, C.A., Regimig, P., Holzapfel, G.A., Mechanics of the human femoral adventitia including the high-pressure response (2002) Am J Physiol Heart Circ Physiol, 282, pp. H2427-H2440
  • Sartore, S., Chiavegato, A., Faggin, A., Franch, R., Puato, M., Ausoni, S., Contribution of adventitial fibroblasts to neointima, formation and vascular remodeling from innocent bystander to active participant (2001) Circ Res, 89, pp. 1111-1121
  • Li, G., Chen, S.J., Oparil, S., Chen, Y.F., Thompson, J.A., Direct in vivo evidence demonstrating neointimal migration of adventitial fibroblasts after balloon injury of rat carotid arteries (2000) Circulation, 101, pp. 1362-1365
  • Cabrera-Fischer, E.I., Bia, D., Camus, J.M., Zócalo, Y., De Forteza, E., Armentano, R., Adventitia-dependent mechanical properties of brachiocephalic ovine arteries in in vivo and in vitro studies (2006) Acta Physiol, 188, pp. 103-111
  • Bia, D., Zócalo, Y., Pessana, F., Armentano, R., Pérez Campos, H., Cabrera-Fischer, E.I., Acoplantiento viscoelástico y funcional entre arterias nativas y homoinjertos arteriales y venosos, frescos y criopreservados (2006) Rev Esp Cardiol, 59, pp. 679-687
  • Kelly, R.P., Tunin, R., Kass, D.A., Effect of reduced aortic compliance on cardiac efficiency and contractile function of in situ canine left ventricle (1992) Circ Res, 71, pp. 490-502

Citas:

---------- APA ----------
Bia, D., Zócalo, Y., Armentano, R.L., Camus, J., de Forteza, E. & Cabrera-Fischer, E. (2007) . The adventitia reduces left ventricular dynamic afterload via smooth muscle activation-dependent machanisms . Revista Espanola de Cardiologia, 60(5), 501-509.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03008932_v60_n5_p501_Bia [ ]
---------- CHICAGO ----------
Bia, D., Zócalo, Y., Armentano, R.L., Camus, J., de Forteza, E., Cabrera-Fischer, E. "The adventitia reduces left ventricular dynamic afterload via smooth muscle activation-dependent machanisms " . Revista Espanola de Cardiologia 60, no. 5 (2007) : 501-509.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03008932_v60_n5_p501_Bia [ ]
---------- MLA ----------
Bia, D., Zócalo, Y., Armentano, R.L., Camus, J., de Forteza, E., Cabrera-Fischer, E. "The adventitia reduces left ventricular dynamic afterload via smooth muscle activation-dependent machanisms " . Revista Espanola de Cardiologia, vol. 60, no. 5, 2007, pp. 501-509.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03008932_v60_n5_p501_Bia [ ]
---------- VANCOUVER ----------
Bia, D., Zócalo, Y., Armentano, R.L., Camus, J., de Forteza, E., Cabrera-Fischer, E. The adventitia reduces left ventricular dynamic afterload via smooth muscle activation-dependent machanisms . Rev. Esp. Cardiol. 2007;60(5):501-509.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03008932_v60_n5_p501_Bia [ ]