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Abstract:

Microsomal preparations from malignant human breast tumors catalyzed the transfer of mannose and glucose from GDP-[14C]-Man and UDP-[14C]-Glc into lipid-linked sugars and glycoprotein-like substances. As judged by several criteria the obtained lipid-linked monosaccharides behaved as dolichyl phosphate mannose and dolichyl phosphate glucose whereas lipid-linked oligosaccharides behaved as polyprenyl diphosphate derivatives. The optimum conditions for mannosyl and glucosyl - transfer reactions and the effect of dolichyl phosphate, detergent and EDTA on incubation mixture were described. © 1983 Martinus Nijhoff Publishers.

Registro:

Documento: Artículo
Título:Lipid-bound sugars in malignant human breast tumors - Partial characterization of mannosyl and glucosyl transferase activities
Autor:Santa Cruza, A.R.; Quesada Allue, L.A.; Baldi, A.
Filiación:Instituto de Biologiá y Medicina Experimental, 'Fundación Campomar', Obligado 2490, Buenos Aires, 1428, Argentina
Instituto de Investigaciones Bioquímicas, 'Fundación Campomar', Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:carbon; diagnostic agent; glucosyltransferase; glycoprotein; glycosyltransferase; guanosine diphosphate mannose; isoprenoid phosphate sugar; mannosyltransferase; nucleoside diphosphate sugar; uridine diphosphate glucose; uridine diphosphate sugar; article; biosynthesis; breast tumor; enzymology; female; human; kinetics; metabolism; microsome; Breast Neoplasms; Carbon Radioisotopes; Female; Glucosyltransferases; Glycoproteins; Guanosine Diphosphate Mannose; Hexosyltransferases; Human; Kinetics; Mannosyltransferases; Microsomes; Nucleoside Diphosphate Sugars; Polyisoprenyl Phosphate Oligosaccharides; Support, Non-U.S. Gov't; Uridine Diphosphate Glucose; Uridine Diphosphate Sugars
Año:1983
Volumen:56
Número:1
Página de inicio:55
Página de fin:66
DOI: http://dx.doi.org/10.1007/BF00228769
Título revista:Molecular and Cellular Biochemistry
Título revista abreviado:Mol Cell Biochem
ISSN:03008177
CODEN:MCBIB
CAS:carbon, 7440-44-0; glucosyltransferase, 9031-48-5; glycosyltransferase, 9033-07-2; guanosine diphosphate mannose, 3123-67-9; mannosyltransferase, 9055-06-5; uridine diphosphate glucose, 133-89-1; Carbon Radioisotopes; Glucosyltransferases, EC 2.4.1.-; Glycoproteins; Guanosine Diphosphate Mannose, 3123-67-9; Hexosyltransferases, EC 2.4.1.-; Mannosyltransferases, EC 2.4.1.; Nucleoside Diphosphate Sugars; Polyisoprenyl Phosphate Oligosaccharides; Uridine Diphosphate Glucose, 133-89-1; Uridine Diphosphate Sugars
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03008177_v56_n1_p55_SantaCruza

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Citas:

---------- APA ----------
Santa Cruza, A.R., Quesada Allue, L.A. & Baldi, A. (1983) . Lipid-bound sugars in malignant human breast tumors - Partial characterization of mannosyl and glucosyl transferase activities. Molecular and Cellular Biochemistry, 56(1), 55-66.
http://dx.doi.org/10.1007/BF00228769
---------- CHICAGO ----------
Santa Cruza, A.R., Quesada Allue, L.A., Baldi, A. "Lipid-bound sugars in malignant human breast tumors - Partial characterization of mannosyl and glucosyl transferase activities" . Molecular and Cellular Biochemistry 56, no. 1 (1983) : 55-66.
http://dx.doi.org/10.1007/BF00228769
---------- MLA ----------
Santa Cruza, A.R., Quesada Allue, L.A., Baldi, A. "Lipid-bound sugars in malignant human breast tumors - Partial characterization of mannosyl and glucosyl transferase activities" . Molecular and Cellular Biochemistry, vol. 56, no. 1, 1983, pp. 55-66.
http://dx.doi.org/10.1007/BF00228769
---------- VANCOUVER ----------
Santa Cruza, A.R., Quesada Allue, L.A., Baldi, A. Lipid-bound sugars in malignant human breast tumors - Partial characterization of mannosyl and glucosyl transferase activities. Mol Cell Biochem. 1983;56(1):55-66.
http://dx.doi.org/10.1007/BF00228769