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Abstract:

The appearance of a protein (association factor I) in ribosomes from Bacillus stearothermophilus at stationary phase of growth is described. Association factor I is present on 30S subunits and 30S-50S ribosomal couples, but not on 50S subunits. This protein is responsible for the low levels of polyphenylalanine synthesis shown by stationary phase ribosomes. Association factor I is able to bind to free 30S-50S ribosomal couples but not to polysomes, and exerts its effect by inhibiting the initiation step of protein synthesis. Ribosomes preincubated with association factor I have a decreased ability for polypeptide snythesis directed phage mRNA or poly(U). © 1980 Dr. W. Junk b.v. Publishers.

Registro:

Documento: Artículo
Título:Mechanism of protein synthesis inhibition during stationary phase in Bacillus stearothermophil US
Autor:Garcia-Patrone, M.
Filiación:Instituto de Investigaciones Bioquímicas 'Fundación Campomar', and Facultad de Ciencias Exactas y Naturales, Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:animal experiment; bacillus stearothermophilus; in vitro study; protein synthesis; Bacillus stearothermophilus; Bacterial Proteins; Cell Cycle; Coliphages; Peptide Chain Initiation; Peptide Synthesis; Phenylalanine; Poly U; Ribosomal Proteins; Ribosomes; RNA, Messenger; RNA, Viral
Año:1980
Volumen:31
Número:2
Página de inicio:97
Página de fin:103
DOI: http://dx.doi.org/10.1007/BF00240815
Título revista:Molecular and Cellular Biochemistry
Título revista abreviado:Mol Cell Biochem
ISSN:03008177
CODEN:MCBIB
CAS:Bacterial Proteins; Phenylalanine, 63-91-2; Poly U, 27416-86-0; polyphenylalanine, 30394-07-1; Ribosomal Proteins; RNA, Messenger; RNA, Viral
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03008177_v31_n2_p97_GarciaPatrone

Referencias:

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Citas:

---------- APA ----------
(1980) . Mechanism of protein synthesis inhibition during stationary phase in Bacillus stearothermophil US. Molecular and Cellular Biochemistry, 31(2), 97-103.
http://dx.doi.org/10.1007/BF00240815
---------- CHICAGO ----------
Garcia-Patrone, M. "Mechanism of protein synthesis inhibition during stationary phase in Bacillus stearothermophil US" . Molecular and Cellular Biochemistry 31, no. 2 (1980) : 97-103.
http://dx.doi.org/10.1007/BF00240815
---------- MLA ----------
Garcia-Patrone, M. "Mechanism of protein synthesis inhibition during stationary phase in Bacillus stearothermophil US" . Molecular and Cellular Biochemistry, vol. 31, no. 2, 1980, pp. 97-103.
http://dx.doi.org/10.1007/BF00240815
---------- VANCOUVER ----------
Garcia-Patrone, M. Mechanism of protein synthesis inhibition during stationary phase in Bacillus stearothermophil US. Mol Cell Biochem. 1980;31(2):97-103.
http://dx.doi.org/10.1007/BF00240815