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Mazaira, G.I.; Daneri-Becerra, C.; Zgajnar, N.R.; Lotufo, C.M.; Galigniana, M.D. "Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90" (2018) Biochemical Society Transactions. 46(1):51-65
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Abstract:

The ability to permit gene expression is managed by a set of relatively well known regulatory mechanisms. Nonetheless, this property can also be acquired during a life span as a consequence of environmental stimuli. Interestingly, some acquired information can be passed to the next generation of individuals without modifying gene information, but instead by the manner in which cells read and process such information. Molecular chaperones are classically related to the proper preservation of protein folding and anti-aggregation properties, but one of them, heat-shock protein 90 (Hsp90), is a refined sensor of protein function facilitating the biological activity of properly folded client proteins that already have a preserved tertiary structure. Interestingly, Hsp90 can also function as a critical switch able to regulate biological responses due to its association with key client proteins such as histone deacetylases or DNA methylases. Thus, a growing amount of evidence has connected the action of Hsp90 to post-translational modifications of soluble nuclear factors, DNA, and histones, which epigenetically affect gene expression upon the onset of an unfriendly environment. This response is commanded by the activation of the transcription factor heat-shock factor 1 (HSF1). Even though numerous stresses of diverse nature are known to trigger the stress response by activation of HSF1, it is still unknown whether there are different types of molecular sensors for each type of stimulus. In the present review, we will discuss various aspects of the regulatory action of HSF1 and Hsp90 on transcriptional regulation, and how this regulation may affect genetic assimilation mechanisms and the health of individuals. © 2018 The Author(s).

Registro:

Documento: Artículo
Título:Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90
Autor:Mazaira, G.I.; Daneri-Becerra, C.; Zgajnar, N.R.; Lotufo, C.M.; Galigniana, M.D.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Biología y Medicina Experimental (IBYME)-CONICET, Buenos Aires, 1428, Argentina
Palabras clave:chaperone; heat shock protein 90; heat shock transcription factor 1; histone deacetylase 6; HDAC6 protein, human; heat shock protein 90; heat shock transcription factor; histone deacetylase 6; HSF1 protein, human; gene expression regulation; genetic variation; human; nonhuman; priority journal; protein processing; Review; stress; animal; gene expression regulation; genetic transcription; physiological stress; physiology; protein folding; Animals; Gene Expression Regulation; Genetic Variation; Heat Shock Transcription Factors; Histone Deacetylase 6; HSP90 Heat-Shock Proteins; Humans; Protein Folding; Protein Processing, Post-Translational; Stress, Physiological; Transcription, Genetic
Año:2018
Volumen:46
Número:1
Página de inicio:51
Página de fin:65
DOI: http://dx.doi.org/10.1042/BST20170335
Título revista:Biochemical Society Transactions
Título revista abreviado:Biochem. Soc. Trans.
ISSN:03005127
CODEN:BCSTB
CAS:HDAC6 protein, human; Heat Shock Transcription Factors; Histone Deacetylase 6; HSF1 protein, human; HSP90 Heat-Shock Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03005127_v46_n1_p51_Mazaira

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Citas:

---------- APA ----------
Mazaira, G.I., Daneri-Becerra, C., Zgajnar, N.R., Lotufo, C.M. & Galigniana, M.D. (2018) . Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90. Biochemical Society Transactions, 46(1), 51-65.
http://dx.doi.org/10.1042/BST20170335
---------- CHICAGO ----------
Mazaira, G.I., Daneri-Becerra, C., Zgajnar, N.R., Lotufo, C.M., Galigniana, M.D. "Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90" . Biochemical Society Transactions 46, no. 1 (2018) : 51-65.
http://dx.doi.org/10.1042/BST20170335
---------- MLA ----------
Mazaira, G.I., Daneri-Becerra, C., Zgajnar, N.R., Lotufo, C.M., Galigniana, M.D. "Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90" . Biochemical Society Transactions, vol. 46, no. 1, 2018, pp. 51-65.
http://dx.doi.org/10.1042/BST20170335
---------- VANCOUVER ----------
Mazaira, G.I., Daneri-Becerra, C., Zgajnar, N.R., Lotufo, C.M., Galigniana, M.D. Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90. Biochem. Soc. Trans. 2018;46(1):51-65.
http://dx.doi.org/10.1042/BST20170335