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Espada, R.; Parra, R.G.; Sippl, M.J.; Mora, T.; Walczak, A.M.; Ferreiro, D.U. "Repeat proteins challenge the concept of structural domains" (2015) Biochemical Society Transactions. 43:844-849
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Abstract:

Structural domains are believed to be modules within proteins that can fold and function independently. Some proteins show tandem repetitions of apparent modular structure that do not fold independently, but rather co-operate in stabilizing structural forms that comprise several repeat-units. For many natural repeat-proteins, it has been shown that weak energetic links between repeats lead to the breakdown of co-operativity and the appearance of folding sub-domains within an apparently regular repeat array. The quasi-1D architecture of repeat-proteins is crucial in detailing how the local energetic balances can modulate the folding dynamics of these proteins, which can be related to the physiological behaviour of these ubiquitous biological systems. © 2015 Authors; published by Portland Press Limited.

Registro:

Documento: Artículo
Título:Repeat proteins challenge the concept of structural domains
Autor:Espada, R.; Parra, R.G.; Sippl, M.J.; Mora, T.; Walczak, A.M.; Ferreiro, D.U.
Filiación:Protein Physiology Lab., Dep de Química Biológica, Facultad de Ciencias Exactas y Naturales, UBA-CONICET-IQUIBICEN, Buenos Aires, C1430EGA, Argentina
Center of Applied Molecular Engineering, Division of Bioinformatics, Department of Molecular Biology, University of Salzburg, Salzburg, 5020, Austria
Laboratoire de Physique Statistique, CNRS, UPMC, Ecole Normale Supérieure, 24 rue Lhomond, Paris, 75005, France
Laboratoire de Physique Théorique, CNRS, UPMC, Ecole Normale Supérieure, 24 rue Lhomond, Paris, 75005, France
Palabras clave:Ankyrin-repeat; Local frustration; Repeat-protein; protein; repeat protein; unclassified drug; Article; molecular evolution; physiological process; priority journal; protein analysis; protein domain; protein folding; amino acid sequence; animal; chemical structure; energy transfer; human; protein conformation; protein domain; protein secondary structure; protein stability; protein tertiary structure; tandem repeat; Animals; Energy Transfer; Evolution, Molecular; Humans; Models, Molecular; Protein Conformation; Protein Folding; Protein Interaction Domains and Motifs; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid; Tandem Repeat Sequences
Año:2015
Volumen:43
Página de inicio:844
Página de fin:849
DOI: http://dx.doi.org/10.1042/BST20150083
Título revista:Biochemical Society Transactions
Título revista abreviado:Biochem. Soc. Trans.
ISSN:03005127
CODEN:BCSTB
CAS:protein, 67254-75-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03005127_v43_n_p844_Espada

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Citas:

---------- APA ----------
Espada, R., Parra, R.G., Sippl, M.J., Mora, T., Walczak, A.M. & Ferreiro, D.U. (2015) . Repeat proteins challenge the concept of structural domains. Biochemical Society Transactions, 43, 844-849.
http://dx.doi.org/10.1042/BST20150083
---------- CHICAGO ----------
Espada, R., Parra, R.G., Sippl, M.J., Mora, T., Walczak, A.M., Ferreiro, D.U. "Repeat proteins challenge the concept of structural domains" . Biochemical Society Transactions 43 (2015) : 844-849.
http://dx.doi.org/10.1042/BST20150083
---------- MLA ----------
Espada, R., Parra, R.G., Sippl, M.J., Mora, T., Walczak, A.M., Ferreiro, D.U. "Repeat proteins challenge the concept of structural domains" . Biochemical Society Transactions, vol. 43, 2015, pp. 844-849.
http://dx.doi.org/10.1042/BST20150083
---------- VANCOUVER ----------
Espada, R., Parra, R.G., Sippl, M.J., Mora, T., Walczak, A.M., Ferreiro, D.U. Repeat proteins challenge the concept of structural domains. Biochem. Soc. Trans. 2015;43:844-849.
http://dx.doi.org/10.1042/BST20150083