Abstract:
The effect of griseofulvin on porphyrin biosynthesis was studied in vitro and in vivo using liver and skin explants from mice. Neither porphyrin nor precursors accumulation was detected after in vitro treatment of explants with griseofulvin. Culture medium porphyrins formed from added σ-amino-laevulinic acid (ALA) were increased after oral chronic intoxication. Similar results were obtained by cutaneous and oral intoxication. Consequently griseofulvin topical application is proposed as an alternative method to produce experimental erythropoietic protoporphyria. Probable intoxication mechanism are proposed to explain the porphyrinogenic action of griseofulvin. © 1987.
Registro:
Documento: |
Artículo
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Título: | The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures |
Autor: | Vasquez, E.; Afonso, S.; Buzaleh, A.M.; Navone, N.; Polo, C.; Schoua, E.; Batlle, A. |
Filiación: | Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) - (UBA) and CONICET, Ciudad Universitaria, Pabellón II, 2do. Piso, 1428 Buenos Aires, Argentina
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Palabras clave: | Griseofulvin; Haem; N-methylporphyrins; Porphyrins; Tissue culture; griseofulvin; heme; porphyrin; animal cell; animal experiment; blood and hemopoietic system; congenital erythropoietic porphyria; drug mechanism; drug overdose; in vitro study; intoxication; liver; mouse; n methylporphyrin derivative; nonhuman; oral drug administration; skin; subcutaneous drug administration; tissue culture; Animal; Griseofulvin; Heme; Liver; Male; Mice; Porphyrins; Skin; Support, Non-U.S. Gov't; Tissue Culture |
Año: | 1987
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Volumen: | 46
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Número: | 1
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Página de inicio: | 73
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Página de fin: | 82
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DOI: |
http://dx.doi.org/10.1016/0300-483X(87)90139-9 |
Título revista: | Toxicology
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Título revista abreviado: | Toxicology
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ISSN: | 0300483X
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CODEN: | TXCYA
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CAS: | griseofulvin, 126-07-8; heme, 14875-96-8; porphyrin, 24869-67-8; Griseofulvin, 126-07-8; Heme, 14875-96-8; Porphyrins
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v46_n1_p73_Vasquez |
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Citas:
---------- APA ----------
Vasquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E. & Batlle, A.
(1987)
. The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures. Toxicology, 46(1), 73-82.
http://dx.doi.org/10.1016/0300-483X(87)90139-9---------- CHICAGO ----------
Vasquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E., et al.
"The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures"
. Toxicology 46, no. 1
(1987) : 73-82.
http://dx.doi.org/10.1016/0300-483X(87)90139-9---------- MLA ----------
Vasquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E., et al.
"The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures"
. Toxicology, vol. 46, no. 1, 1987, pp. 73-82.
http://dx.doi.org/10.1016/0300-483X(87)90139-9---------- VANCOUVER ----------
Vasquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E., et al. The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures. Toxicology. 1987;46(1):73-82.
http://dx.doi.org/10.1016/0300-483X(87)90139-9