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Abstract:

The effect of griseofulvin on porphyrin biosynthesis was studied in vitro and in vivo using liver and skin explants from mice. Neither porphyrin nor precursors accumulation was detected after in vitro treatment of explants with griseofulvin. Culture medium porphyrins formed from added σ-amino-laevulinic acid (ALA) were increased after oral chronic intoxication. Similar results were obtained by cutaneous and oral intoxication. Consequently griseofulvin topical application is proposed as an alternative method to produce experimental erythropoietic protoporphyria. Probable intoxication mechanism are proposed to explain the porphyrinogenic action of griseofulvin. © 1987.

Registro:

Documento: Artículo
Título:The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures
Autor:Vasquez, E.; Afonso, S.; Buzaleh, A.M.; Navone, N.; Polo, C.; Schoua, E.; Batlle, A.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) - (UBA) and CONICET, Ciudad Universitaria, Pabellón II, 2do. Piso, 1428 Buenos Aires, Argentina
Palabras clave:Griseofulvin; Haem; N-methylporphyrins; Porphyrins; Tissue culture; griseofulvin; heme; porphyrin; animal cell; animal experiment; blood and hemopoietic system; congenital erythropoietic porphyria; drug mechanism; drug overdose; in vitro study; intoxication; liver; mouse; n methylporphyrin derivative; nonhuman; oral drug administration; skin; subcutaneous drug administration; tissue culture; Animal; Griseofulvin; Heme; Liver; Male; Mice; Porphyrins; Skin; Support, Non-U.S. Gov't; Tissue Culture
Año:1987
Volumen:46
Número:1
Página de inicio:73
Página de fin:82
DOI: http://dx.doi.org/10.1016/0300-483X(87)90139-9
Título revista:Toxicology
Título revista abreviado:Toxicology
ISSN:0300483X
CODEN:TXCYA
CAS:griseofulvin, 126-07-8; heme, 14875-96-8; porphyrin, 24869-67-8; Griseofulvin, 126-07-8; Heme, 14875-96-8; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v46_n1_p73_Vasquez

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Citas:

---------- APA ----------
Vasquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E. & Batlle, A. (1987) . The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures. Toxicology, 46(1), 73-82.
http://dx.doi.org/10.1016/0300-483X(87)90139-9
---------- CHICAGO ----------
Vasquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E., et al. "The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures" . Toxicology 46, no. 1 (1987) : 73-82.
http://dx.doi.org/10.1016/0300-483X(87)90139-9
---------- MLA ----------
Vasquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E., et al. "The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures" . Toxicology, vol. 46, no. 1, 1987, pp. 73-82.
http://dx.doi.org/10.1016/0300-483X(87)90139-9
---------- VANCOUVER ----------
Vasquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E., et al. The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures. Toxicology. 1987;46(1):73-82.
http://dx.doi.org/10.1016/0300-483X(87)90139-9