Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Pyrethroids (PYRs) are synthetic insecticides increasingly used in agricultural and household pest control. Little is known on how the toxicity of highly effective bolus doses of single compounds compares to more realistic scenarios of low-level exposure to PYR mixtures. In this study, we examined a quaternary mixture of two noncyano (tefluthrin, TEF; bifenthrin, BIF) and two cyano (α-cypermethrin, α-CPM; deltamethrin, DTM) PYRs in young adult rats. These compounds are mostly composed of PYR isomers ranking top ten in acute lethality in rats. Concurrently, we administered near-threshold levels of the four PYRs dissolved in corn oil by oral route. Six hours later blood was collected and the liver and cerebellum were dissected out to determine PYR concentrations in these tissues using Gas Chromatography with Electron Capture Detector (GC-ECD). The mixture caused mild-to-moderate changes in non-locomotor behaviors and subcutaneous body temperature (up to +1.2–1.5 °C increase at 2–4 h after dosing, respectively, compared to pre-dosing records). The most toxic PYRs BIF and TEF reached higher concentrations in the cerebellum than the cyano-compounds α-CPM and DTM. In addition, PYR concentrations in the cerebellum were correlated to single compound proportions in the dosing solution and changes in body temperature. Our results suggest that aggregate exposures resulting in a target tissue burden of ∼10−1 nmoles PYR/g may be toxicologically relevant, expanding the evidence on exposure-dose-effect relationships for PYRs, and serving to design convenient pharmacokinetic models for environmentally relevant exposures to PYR mixtures. © 2018

Registro:

Documento: Artículo
Título:Relationship between exposure, body burden and target tissue concentration after oral administration of a low-dose mixture of pyrethroid insecticides in young adult rats
Autor:Mosquera Ortega, M.E.; Romero, D.M.; Pato, A.M.; Sosa-Holt, C.S.; Ridolfi, A.; Villaamil Lepori, E.; Wolansky, M.J.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Argentina
Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina
IQUIBICEN Institute, Consejo Nacional de Investigaciones Científicas, CONICET, Argentina
Cortical Development and Pathology, Institut du Fer a Moulin, INSERM, UMRS 839, 17 Rue du Fer a Moulin, Paris, 75005, France
Palabras clave:Body temperature; Cumulative toxicity; Mixture; Pyrethroids; Rat; Toxicokinetics; bifenthrin; corn oil; cypermethrin; deltamethrin; pyrethroid; tefluthrin; unclassified drug; adult; animal experiment; animal model; animal tissue; Article; body burden; body temperature; cerebellum; controlled study; gas chromatography; lethality; liver; locomotion; neurotoxicity; nonhuman; priority journal; rat; target tissue; young adult
Año:2018
Volumen:409
Página de inicio:53
Página de fin:62
DOI: http://dx.doi.org/10.1016/j.tox.2018.07.006
Título revista:Toxicology
Título revista abreviado:Toxicology
ISSN:0300483X
CODEN:TXCYA
CAS:bifenthrin, 82657-04-3; corn oil, 8001-30-7; cypermethrin, 52315-07-8, 65731-84-2, 66841-24-5, 67375-30-8; deltamethrin, 52918-63-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v409_n_p53_MosqueraOrtega

Referencias:

  • Abdel-Rahman, A., Shetty, A.K., Abou-Donia, M.B., Subchronic Dermal Application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum (2001) Exp. Neurol., 172, pp. 153-171
  • Anadón, A., Martinez-Larrañaga, M.R., Diaz, M.J., Bringas, P., Toxicokinetics of permethrin in the rat (1991) Toxicol. Appl. Pharmacol., 110 (1), pp. 1-8
  • ATSDR, Toxicological Profile for Pyrethrins and Pyrethroids. Section 4, Chemical and Physical Information (2003), https://www.atsdr.cdc.gov/toxprofiles/tp155.pdf, September 2003. Available at: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry; Bardullas, U., Sosa-Holt, C.S., Pato, A.M., Nemirovsky, S.I., Wolansky, M.J., Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats (2015) Neurotoxicol. Teratol., 52, pp. 1-10
  • Casida, J.E., Pyrethrum flowers and pyrethroid insecticides (1980) Environ. Health Perspect., 34, pp. 189-202
  • CDPR, Summary of Toxicological Data: Cypermethrin, Zeta-cypermethrin, Alpha-cypermethrin (2016), California Environmental Protection Agency, Department of Pesticide Regulation, Human Health Assessment Branch February 16th 2016; Cremer, J.E., Seville, M.P., Changes in regional cerebral blood flow and glucose metabolism associated with symptoms of pyrethroid toxicity (1985) Neurotoxicology, 6, pp. 1-12
  • Crofton, K.M., Reiter, L.W., Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat (1984) Toxicol. Appl. Pharmacol., 75, pp. 318-328
  • Crofton, K.M., Reiter, L.W., The effects of type I and II pyrethroids on motor activity and the acoustic startle response in the rat (1988) Fundam. Appl. Toxicol., 10, pp. 624-634
  • Dayal, M., Parmar, D., Ali, M., Dhawan, A., Dwivedi, U.N., Seth, P.K., Induction of rat brain cytochrome P450s (P450s) by deltamethrin: regional specificity and correlation with neurobehavioral toxicity (2001) Neurotox. Res., 3, pp. 351-357
  • Elliott, M., Properties and applications of pyrethroids (1976) Environ. Health Perspect., 14, pp. 1-13
  • Gammon, D.W., Chandrasekaran, A., ElNaggar, S.F., Comparative Metabolism and Toxicology of Pyrethroids in Mammals (2012), pp. 137-183. , Chapter 5; Gammon, D.W., Liu, Z., Chandrasekaran, A., ElNaggar, S.F., The pharmacokinetic properties of bifenthrin in the rat following multiple routes of exposure (2014) Pest Manag. Sci., 71, pp. 835-841
  • Gordon, C.J., Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach (2005), Taylor & Francis; Gray, A.J., Rickard, J., Toxicity of pyrethroids to rats after direct injection into the central nervous system (1982) Neurotoxicology, 3, pp. 25-35
  • Haines, D.A., Saravanabhavan, G., Werry, K., Khoury, C., An overview of human biomonitoring of environmental chemicals in the Canadian Health Measures Survey: 2007-2019 (2017) Int. J. Hyg. Environ. Health, 220, pp. 13-28
  • Hershey, J.D., Aler, D., Miller, S., Surface temperature correlates to core body temperature in mice across a wide range of values (2014) Lab. Anim. Sci. Prof., 4, pp. 44-46
  • Holton, J.L., Nolan, C.C., Burr, S.A., Ray, D.E., Cavanagh, J.B., Increasing or decreasing nervous activity modulates the severity of the glio-vascular lesions of 1,3-dinitrobenzene in the rat: effects of the tremorgenic pyrethroid, Bifenthrin, and of anaesthesia (1997) Acta Neuropathol., 93, pp. 159-165
  • Hughes, M.F., Ross, D.G., Starr, J.M., Scollon, E.J., Wolansky, M.J., Crofton, K.M., DeVito, M.J., Environmentally relevant pyrethroid mixtures: a study n the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to motor activity in the rat (2016) Toxicology, 359, pp. 19-28
  • Hughes, M.F., Ross, D.G., Edwards, B.C., DeVito, M.J., Starr, J.M., Tissue time course and bioavailability of the pyrethroid insecticide bifenthrin in the Long-Evans rat (2016) Xenobiotica, 46, pp. 430-438
  • Jardim, A.N.O., Caldas, E.D., Brazilian monitoring programs for pesticide residues in food – Results from 2001 to 2010 (2012) Food Control, 25, pp. 607-616
  • Julien, R., Adamkiewicz, G., Levy, J.I., Bennett, D., Nishioka, M., Spengler, J.D., Pesticide loadings of select organophosphate and pyrethroid pesticides in urban public housing (2008) J. Expo. Sci. Environ. Epidemiol., 18, pp. 167-174
  • Kim, K.B., Anand, S.S., Muralidhara, S., Kim, H.J., Bruckner, J.V., Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats (2007) Toxicology, 234 (3), pp. 194-202
  • Knaak, J.B., Dary, C.C., Zhang, X., Gerlach, R.W., Tornero-Velez, R., Chang, D.T., Parameters for pyrethroid insecticide QSAR and PBPK/PD models for human risk assessment (2012) Rev. Environ. Contam. Toxicol., 219, pp. 121-130. , D.M. Whitacre
  • Kort, W.J., Hekking-Weijma, J.M., Tenkate, M.T., Sorm, V., VanStrik, R., A microchip implant system as a method to determine body temperature of terminally ill rats and mice (1998) Lab. Anim., 32, pp. 260-269
  • Lawrence, L.J., Casida, J.E., Pyrethroid toxicology: mouse intracerebral structure-toxicity relationships (1982) Pestic. Biochem. Physiol., 18, pp. 9-14
  • Li, H., Ma, H., Lydy, M.J., You, J., Occurrence, seasonal variation and inhalation exposure of atmospheric organophosphate and pyrethroid pesticides in an urban community in South China (2014) Chemosphere, 95, pp. 363-369
  • McDaniel, K.L., Moser, V.C., Utility of a neurobehavioral screening battery for differentiating the effects of two pyrethroids, permethrin and cypermethrin (1993) Neurotoxicol. Teratol., 15, pp. 71-83
  • Miller, J.N., Miller, J.C., Statistics and Chemometrics for Analytical Chemistry (2005), Pearson/Prentice Hall London; Morgan, M.K., Children's exposures to pyrethroid insecticides at home: a review of data collected in published exposure measurement studies conducted in the United States (2012) Int. J. Environ. Res. Public Health, 9, pp. 2964-2985
  • Mosquera-Ortega, M., Pato, A., Sosa-Holt, C., Ridolfi, A., Wolansky, M.J., Villaamil, E., Relationship between administered dose, target tissue levels and thermoregulatory response alterations after acute oral exposure to the potent tremor-inducing pyrethroid bifenthrin in rats (2013) The Toxicologist, 132, p. 1412
  • Narahashi, T., Neuroreceptors and ion channels as the basis for drug action past, present, and future (2000) J. Pharmacol. Exp. Ther., 294 (1), pp. 1-26
  • Oltra-Noguera, D., Mangas-Sanjuan, V., González-Álvarez, I., Colon-Useche, S., González-Álvarez, M., Bermejo, M., Drug gastrointestinal absorption in rat: strain and gender differences (2015) Eur. J. Pharm. Sci., 78, pp. 198-203
  • Pato, A.M., Sosa Holt, C., Wolansky, M.J., Time, dose, and structure dependent actions of pyrethroid insecticides on rat thermoregulation (2011) The Toxicologist, 120, p. P1346
  • Pronk, M.E., Speijers, G.J., Wouters, M.F., Ritter, L., Cypermethrin and Alpha-cypermethrin (WHO Food Additives Series 38) (1996), http://www.inchem.org/documents/jecfa/jecmono/v38je07.htm, [WWW Document]. URL; Saillenfait, A.M., Ndiaye, D., Sabaté, J.P., Pyrethroids: Exposure and health effects: An update (2015) Intl. J. Hyg. Environ. Health, 218 (3), pp. 281-292
  • Scollon, E.J., Starr, J.M., Crofton, K.M., Wolansky, M.J., DeVito, M.J., Hughes, M.F., Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat (2011) Toxicology, 290, pp. 1-6
  • Soderlund, D.M., Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances (2012) Arch. Toxicol., 86, pp. 165-181
  • Soderlund, D.M., Clark, J.M., Sheets, L.P., Mullin, L.S., Piccirillo, V.J., Sargent, D., Stevens, J.T., Weiner, M.L., Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment (2002) Toxicology, 171, pp. 3-59
  • Song, J.H., Narahashi, T., Modulation of sodium channels of rat cerebellar Purkinje neurons by the pyrethroid tetramethrin (1996) J. Pharmacol. Exp. Ther., 277, pp. 445-453
  • Starr, J.M., Scollon, E.J., Hughes, M.F., Ross, D.G., Graham, S.E., Crofton, K.M., Wolansky, M.J., Tornero-Velez, R., Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids (2012) Toxicol. Sci., 130, pp. 309-318
  • Starr, J.M., Graham, S.E., Ross, D.G., Tornero-Velez, R., Scollon, E.J., Devito, M.J., Crofton, K.M., Hughes, M.F., Environmentally relevant mixing ratios in cumulative assessments: a study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats (2014) Toxicology, 320, pp. 15-24
  • Tornero-Velez, R., Mirfazaelian, A., Kim, K.-B., Anand, S.S., Kim, H.J., Haines, W.T., Bruckner, J.V., Fisher, J.W., Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model (2010) Toxicol. Appl. Pharmacol., 244, pp. 208-217
  • Tornero-Velez, R., Davis, J., Scollon, E.J., Starr, J.M., Setzer, R.W., Goldsmith, M.-R., Chang, D.T., Hughes, M.F., A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application (2012) Toxicol. Sci., 130, pp. 33-47
  • Tornero-Velez, R., Egeghy, P.P., Cohen Hubal, E.A., Biogeographical analysis of chemical co-occurrence data to identify priorities for mixtures research (2012) Risk Anal., 32, pp. 224-236
  • Tulve, N.S., Jones, P., Nishioka, M.G., Fortmann, R.C., Croghan, C.W., Zhou, J.Y., Fraser, A., Friedman, W., Pesticide measurements from the first national environmental health survey of child care centers using a multi-residue GC/MS analysis method (2006) Environ. Sci. Technol., 40, pp. 6269-6274
  • Tulve, N.S., Egeghy, P.P., Fortmann, R.C., Xue, J., Evans, J., Whitaker, D.A., Croghan, C.W., Methodologies for estimating cumulative human exposures to current-use pyrethroid pesticides (2011) J. Expo. Sci. Environ. Epidemiol., 21, pp. 317-327
  • USEPA, Assessing approaches for the development of PBPK models of pyrethroid insecticides (2007) Office of Pesticide Programs (OPP), Office of Research and Development, US Environmental Protection Agency, , https://archive.epa.gov/scipoly/sap/meetings/web/pdf/pyrethroidpbpk_sap_2007_finalv1.pdf, July 18th 2007. Available at
  • Verschoyle, R.D., Aldridge, W.N., Structure-activity relationships of some pyrethroids in rats (1980) Arch. Toxicol., 45, pp. 325-329
  • Vlach, K.D., Boles, J.W., Stiles, B.G., Telemetric evaluation of body temperature and physical activity as predictors of mortality in a murine model of staphylococcal enterotoxic shock (2000) Comp. Med., 50, pp. 160-166
  • Wanner, S.P., Prímola-Gomes, T.N., Pires, W., Guimarães, J.B., Hudson, A.S.R., Kunstetter, A.C., Fonseca, C.G., Teixeira-Coelho, F., Thermoregulatory responses in exercising rats: methodological aspects and relevance to human physiology (2015) Temperature (Austin, Tex.), 2, pp. 457-475
  • WHO, The WHO Recommended Classification of Pesticides by Hazard. Guidelines to Classification 2009 (2010), International Programme on Chemical Safety Geneve; Williams, M.T., Herring, N.R., Schaefer, T.L., Skelton, M.R., Campbell, N.G., Lipton, J.W., McCrea, A.E., Vorhees, C.V., Alterations in body temperature, corticosterone and behavior following the administration of 5-methoxy-diisopropyltryptamine (‘Foxy’) to adult rats: a new drug of abuse (2007) Neuropsychopharmacology, 32, pp. 1404-1420
  • Wolansky, M.J., Harrill, J.A., Neurobehavioral toxicology of pyrethroid insecticides in adult animals: A critical review (2008) Neurotoxicol. Teratol., 30, pp. 55-78
  • Wolansky, M.J., Tornero-Velez, R., Critical consideration of the multiplicity of experimental and organismic determinants of pyrethroid neurotoxicity: a proof of concept (2013) J. Toxicol. Environ. Health B Crit. Rev., 16, pp. 453-490
  • Wolansky, M.J., Gennings, C., Crofton, K.M., Relative potencies for acute effects of pyrethroids on motor function in rats (2006) Toxicol. Sci., 89, pp. 271-277
  • Wolansky, M.J., Mack, C.M., Becker, C.J., Crofton, K.M., Gordon, C.J., Effects of acute pyrethroid exposure on thermoregulation in rats (2007) The Toxicologist, 96 (1), p. P897
  • Wolansky, M.J., McDaniel, K.L., Moser, V.C., Crofton, K.M., Influence of dosing volume on the neurotoxicity of bifenthrin (2007) Neurotoxicol. Teratol., 29, pp. 377-384
  • Wolansky, M.J., Gennings, C., DeVito, M.J., Crofton, K.M., Evidence for dose-additive effects of pyrethroids on motor activity in rats (2009) Environ. Health Perspect., 117, pp. 1563-1570
  • Zartarian, V., Xue, J., Glen, G., Smith, L., Tulve, N., Tornero-Velez, R., Quantifying children's aggregate (dietary and residential) exposure and dose to permethrin: application and evaluation of EPA's probabilistic SHEDS-Multimedia model (2012) J. Expo. Sci. Environ. Epidemiol., 22, pp. 267-273

Citas:

---------- APA ----------
Mosquera Ortega, M.E., Romero, D.M., Pato, A.M., Sosa-Holt, C.S., Ridolfi, A., Villaamil Lepori, E. & Wolansky, M.J. (2018) . Relationship between exposure, body burden and target tissue concentration after oral administration of a low-dose mixture of pyrethroid insecticides in young adult rats. Toxicology, 409, 53-62.
http://dx.doi.org/10.1016/j.tox.2018.07.006
---------- CHICAGO ----------
Mosquera Ortega, M.E., Romero, D.M., Pato, A.M., Sosa-Holt, C.S., Ridolfi, A., Villaamil Lepori, E., et al. "Relationship between exposure, body burden and target tissue concentration after oral administration of a low-dose mixture of pyrethroid insecticides in young adult rats" . Toxicology 409 (2018) : 53-62.
http://dx.doi.org/10.1016/j.tox.2018.07.006
---------- MLA ----------
Mosquera Ortega, M.E., Romero, D.M., Pato, A.M., Sosa-Holt, C.S., Ridolfi, A., Villaamil Lepori, E., et al. "Relationship between exposure, body burden and target tissue concentration after oral administration of a low-dose mixture of pyrethroid insecticides in young adult rats" . Toxicology, vol. 409, 2018, pp. 53-62.
http://dx.doi.org/10.1016/j.tox.2018.07.006
---------- VANCOUVER ----------
Mosquera Ortega, M.E., Romero, D.M., Pato, A.M., Sosa-Holt, C.S., Ridolfi, A., Villaamil Lepori, E., et al. Relationship between exposure, body burden and target tissue concentration after oral administration of a low-dose mixture of pyrethroid insecticides in young adult rats. Toxicology. 2018;409:53-62.
http://dx.doi.org/10.1016/j.tox.2018.07.006