Artículo
Abstract:
In the present study we investigated the porphyrinogenic ability of 4 pesticides: chlordane, endosulfan, parathion and malathion, all of which are widely used in agriculture. In order to determine whether they affect the heme biosynthetic pathway we studied, in 17-day old chick embryo liver "in ovo", their effects on the amount of porphyrins and on the activity of δ-ALA synthetase (ALA-S), the first and rate limiting enzyme of this pathway. All of them induced hepatic porphyrin accumulation to a different extent compared with dimethylsulfoxide (DMSO) controls. Parathion as well as endosulfan promoted remarkable increases, chlordane raised porphyrin level in a lower degree and malathion slightly modified it. However, the accumulation observed with malathion was markedly enhanced if the period of incubation was extended to 48 h and, even more, if a second dose was injected during these 48 h. When ALA-S activity was analyzed in the chick embryos treated with parathion or endosulfan no alteration could be found in spite of producing noticeable accumulation of porphyrins. In contrast, chlordane promoted a statistically significant elevation of ALA-S as well as malathion which produced the highest induction observed. These results show that not only organochlorinated but also organophosphorous pesticides affect heme metabolism and that induction of ALA-S and porphyrin accumulation are not parallel. © 1982.
Registro:
| Documento: | Artículo |
| Título: | Effect of parathion, malathion, endosulfan and chlordane on porphyrin accumulation and alasynthetase in chick embryo liver |
| Autor: | Del C. Vila, M.; San Martín de Viale, L.C. |
| Filiación: | Laboratorio de Porfirinas, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez, 1428, Buenos Aires, Argentina |
| Palabras clave: | 5 aminolevulinate synthase; chlordane; dimethyl sulfoxide; endosulfan; heme; malathion; parathion; porphyrin; animal experiment; chicken; embryo; enzyme induction; intoxication; liver; liver toxicity; nonhuman; 5-Aminolevulinate Synthetase; Animal; Chick Embryo; Chlordan; Dimethyl Sulfoxide; Endosulfan; Liver; Malathion; Parathion; Pesticides; Porphyrins; Support, Non-U.S. Gov't |
| Año: | 1982 |
| Volumen: | 25 |
| Número: | 4 |
| Página de inicio: | 323 |
| Página de fin: | 332 |
| DOI: | http://dx.doi.org/10.1016/0300-483X(82)90110-X |
| Título revista: | Toxicology |
| Título revista abreviado: | Toxicology |
| ISSN: | 0300483X |
| CODEN: | TXCYA |
| CAS: | 5 aminolevulinate synthase, 9037-14-3; chlordane, 12789-03-6, 57-74-9; dimethyl sulfoxide, 67-68-5; endosulfan, 115-29-7; heme, 14875-96-8; malathion, 121-75-5; parathion, 3270-86-8, 56-38-2, 597-88-6; porphyrin, 24869-67-8; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Chlordan, 12789-03-6; Dimethyl Sulfoxide, 67-68-5; Endosulfan, 115-29-7; Malathion, 121-75-5; Parathion, 56-38-2; Pesticides; Porphyrins |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v25_n4_p323_DelCVila |
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Citas:
---------- APA ----------
Del C. Vila, M. & San Martín de Viale, L.C. (1982) . Effect of parathion, malathion, endosulfan and chlordane on porphyrin accumulation and alasynthetase in chick embryo liver. Toxicology, 25(4), 323-332.http://dx.doi.org/10.1016/0300-483X(82)90110-X
---------- CHICAGO ----------
Del C. Vila, M., San Martín de Viale, L.C. "Effect of parathion, malathion, endosulfan and chlordane on porphyrin accumulation and alasynthetase in chick embryo liver" . Toxicology 25, no. 4 (1982) : 323-332.http://dx.doi.org/10.1016/0300-483X(82)90110-X
---------- MLA ----------
Del C. Vila, M., San Martín de Viale, L.C. "Effect of parathion, malathion, endosulfan and chlordane on porphyrin accumulation and alasynthetase in chick embryo liver" . Toxicology, vol. 25, no. 4, 1982, pp. 323-332.http://dx.doi.org/10.1016/0300-483X(82)90110-X
---------- VANCOUVER ----------
Del C. Vila, M., San Martín de Viale, L.C. Effect of parathion, malathion, endosulfan and chlordane on porphyrin accumulation and alasynthetase in chick embryo liver. Toxicology. 1982;25(4):323-332.http://dx.doi.org/10.1016/0300-483X(82)90110-X
