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Abstract:

The naturally occurring polyamines - putrescine, spermidine and spermine - are organic cations present in all living cells and essential for cell growth and differentiation. The aim of the present study was to extend the investigations on the effects of porphyrinogenic compounds on polyamine metabolism. This was achieved by studying putrescine, spermidine and spermine levels in a model of acute porphyria, i.e. 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced porphyria, and in a model of non-acute porphyria, i.e. hexachlorobenzene (HCB)-induced porphyria. HCB administration to female Wistar rats for 7, 14, 21, 28 and 56 days did not alter polyamine levels in liver, even though rats presented clear signs of HCB-induced porphyria. In contrast to HCB, DDC treatment resulted in a remarkable increase in putrescine levels in the liver of female and male Sprague-Dawley rats. This increase was due, at least in part, to ornithine decarboxylase (ODC) activation. DDC induction of putrescine levels did not show organ specificity, since it could also be seen in adrenal gland. Interestingly, the deregulation of polyamine biosynthesis occurred concomitantly with the deregulation of the heme biosynthetic pathway. In addition to porphyria, it is known that DDC intoxication affects several proteins of the hepatocyte cytoskeleton. It is suggested that DDC-induced increase in ODC activity and putrescine levels may be an early event contributing to alter the cytoskeleton. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism
Autor:Cochón, A.C.; González, N.; San Martín De Viale, L.C.
Filiación:Laboratorio De Porfirias Experimentales Y Metabolismo del Hemo, Departamento De Química Biológica, Ciudad Universitaria, Nuñez, 1428 Buenos Aires, Argentina
Instituto De Investigaciones Bioquímicas - Fundación Campomar, P. Argentinas 435, Capital Federal, 1405 Buenos Aires, Argentina
O'Higgins 4332, Capital Federal, 1429 Buenos Aires, Argentina
Palabras clave:3,5-Diethoxycarbonyl-1,4-dihydrocollidine; Hexachlorobenzene; Ornithine decarboxylase; Polyamine; Porphyrin; Putrescine; Rat; Spermidine; Spermine; 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester; hexachlorobenzene; ornithine decarboxylase; putrescine; spermidine; spermine; adrenal gland; animal experiment; animal model; animal tissue; antibody specificity; article; biosynthesis; blood level; controlled study; cytoskeleton; female; liver; liver cell; male; nonhuman; polyamine metabolism; porphyria; priority journal; rat; 5-Aminolevulinate Synthetase; Animals; Biogenic Polyamines; Dicarbethoxydihydrocollidine; Female; Ferrochelatase; Hexachlorobenzene; Liver; Male; Ornithine Decarboxylase; Porphyrins; Proteins; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sex Characteristics; Uroporphyrinogen Decarboxylase; Rattus norvegicus
Año:2002
Volumen:176
Número:3
Página de inicio:209
Página de fin:219
DOI: http://dx.doi.org/10.1016/S0300-483X(02)00145-2
Título revista:Toxicology
Título revista abreviado:Toxicology
ISSN:0300483X
CODEN:TXCYA
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Biogenic Polyamines; Dicarbethoxydihydrocollidine, 632-93-9; Ferrochelatase, EC 4.99.1.1; Hexachlorobenzene, 118-74-1; Ornithine Decarboxylase, EC 4.1.1.17; Porphyrins; Proteins; Uroporphyrinogen Decarboxylase, EC 4.1.1.37
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v176_n3_p209_Cochon

Referencias:

  • (1994) Toxicological Profile for Hexachlorobenzene (Draft), , U.S. Public Health Services, U.S. Department of Health and Human Services, Atlanta, GA
  • Anderson, P.J., Bardocz, S., Campos, R., Brown, D.L., The effect of polyamines on tubulin assembly (1985) Biochem. Biophys. Res. Commun., 132, pp. 147-154
  • Auvinen, M., Cell transformation, invasion, and angiogenesis: A regulatory role for ornithine decarboxylase and polyamines? (1997) J. Natl. Cancer Inst., 89, pp. 533-537
  • Auvinen, M., Paasinen, A., Andersson, L.C., Hölttä, E., Ornithine decarboxylase activity is critical for cell transformation (1992) Nature, 360, pp. 355-358
  • Batlle A.M. del, C., Porphyrins, porphyrias, cancer and photodynamic therapy - A model for carcinogenesis (1993) J. Photochem. Photobiol. B: Biol., 20, pp. 5-22
  • Billi de Catabbi, S.C., Rios de Molina, M.C., San Martín de Viale, L.C., Studies on the active centre of rat liver porphyrinogen carboxy-lyase. In vivo effect of hexachlorobenzene (1991) Int. J. Biochem., 23, pp. 675-679
  • Brooker, J.D., Srivastava, G., Borthwick, I.A., May, B.K., Elliott, W.H., Evidence that 2-allyl-2-isopropylacetamide, phenobarbital and 3,5-diethoxycarbonyl-1,4-dihydrocollidine induce the same cytochrome P450 mRNA in chick embryo liver (1983) Eur. J. Biochem., 136, pp. 327-332
  • Byus, C.V., Costa, M., Sipes, I.G., Brodie, B.B., Russell, D.H., Activation of 3′,5′-cyclic AMP-dependent protein kinase and induction of ornithine decarboxylase as early events in induction of mixed function oxygenases (1976) Proc. Natl. Acad. Sci. (USA), 73, pp. 1241-1245
  • Carthew, P., Smith, A.G., Pathological mechanisms of hepatic tumor formation in rats exposed chronically to dietary hexachlorobenzene (1994) J. App. Toxicol., 14, pp. 447-452
  • Courtney, K.D., Hexachlorobenzene (HCB): A review (1979) Environ. Res., 20, pp. 225-266
  • De Matteis, F., Abbritti, G., Gibbs, A.H., Decreased liver activity of porphyrin-metal chelatase in hepatic porphyria caused by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Studies in rats and mice (1973) Biochem. J., 134, pp. 717-727
  • Denk, H., Stumptner, C., Zatloukal, K., Mallory bodies revisited (2000) J. Hepatol., 32, pp. 689-702
  • Faber, E., Cameron, R., The sequential analysis of cancer development (1980) Adv. Cancer Res., 31, pp. 125-225
  • Goldstein, J.A., Hickman, P., Bergman, H., Vos, J.G., Hepatic porphyria induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (1973) Res. Comm. Chem. Pathol. Pharmacol., 6, pp. 919-928
  • Halmekytö, M., Alhonen, L., Alakuijala, L., Jänne, J., Transgenic mice over-producing putrescine in their tissues do not convert the diamine into higher polyamines (1993) Biochem. J., 291, pp. 505-508
  • Kappas, A., Sassa, S., Galbraith, R.A., Nordmann, Y., The porphyrias (1995) The Metabolic and Molecular Bases of Inherited Disease, pp. 2103-2159. , C.R. Scriver, A.L. Beaudet, W.S. Sly, & D. Valle. New York: Mc Graw-Hill, Inc
  • Kitchin, K.T., Brown, J.L., Biochemical effects of two promoters of hepatocarcinogenesis in rats (1987) Food Chem. Toxicol., 25, pp. 603-607
  • Kitchin, K.T., Brown, J.L., Biochemical studies of promoters of carcinogenesis in rat liver (1989) Teratog. Carcinog. Mutag., 9, pp. 273-285
  • Koss, G., Koransky, W., Studies on the toxicology of hexachlorobenzene I. Pharmacokinetics (1975) Arch. Toxicol., 34, pp. 203-212
  • Lowry, O.H., Rosebrough, A., Farr, L., Randall, R.S., Protein measurement with the folin phenol reagent (1951) J. Biol. Chem., 249, pp. 265-275
  • Lucier, G., Clark, G., Hiermath, C., Tritscher, A., Sewall, C., Huff, J., Carcinogenicity of TCDD in laboratory animals: Implications for risk assessment (1993) Toxicol. Ind. Health, 9, pp. 631-667
  • Mackie, J.E., Back, D.W., Hamilton, J.W., Marks, G.S., Elevation of delta-aminolevulinic acid synthase and cytochrome PB1 P450 messenger RNA levels by dihydropyridines, dihydroquinolines, sydnones, and N-ethylprotoporphyrin IX (1991) Biochem. Pharmacol., 42, pp. 475-483
  • Marcé, M., Brown, D.S., Capell, T., Figueras, X., Tiburcio, A.F., Rapid high-performance liquid chromatographic method for the quantitation of polyamines as their dansyl derivatives: Application to plant and animal tissues (1995) J. Chromatography B, 666, pp. 329-335
  • Marks, G.S., McCluskey, S.A., Mackie, J.E., Riddick, D.S., James, C.A., Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450 (1988) FASEB J., 2, pp. 2774-2783
  • Martini, C.N., Vaena de Avalos, S.G., Romero, D.G., San Martín de Viale, L., Vila, M., Del, C., Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal (1997) Steroids, 62, pp. 767-770
  • Marver, H.S., Tschudy, D.P., Perbroth, M.G., Collins, A., Aminolevulinic acid synthetase. I. Studies in liver homogenates (1966) J. Biol. Chem., 241, pp. 2803-2809
  • Medina, M.A., Quesada, A.R., Nuñez de Castro, I., Sanchez-Jimenez, F., Histamine, polyamines and cancer (1999) Biochem. Pharmacol., 57, pp. 1341-1344
  • Moore, M.R., McColl, K.E.L., Fitzsimons, E.J., Goldberg, A., The porphyrias (1990) Blood Rev., 4, pp. 88-96
  • Nebert, D.W., Jensen, N.M., Perry, J.W., Oka, T., Association between ornithine decarboxylase induction and the Ah locus in mice treated with polycyclic aromatic compounds (1980) J. Biol. Chem., 255, pp. 6836-6842
  • O'Brien, T.G., Simsiman, R.C., Boutwell, R.K., Induction of the polyamine biosynthetic enzymes in mouse epidermis by tumor promoting agents (1981) Cancer Res., 35, pp. 1662-1670
  • Pegg, A.E., Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy (1988) Cancer Res., 48, pp. 759-774
  • Pohjanpelto, P., Virtanen, I., Hölttä, E., Polyamine starvation causes disappearance of actin filaments and microtubules in polyamine-auxotrophic CHO cells (1981) Nature, 293, pp. 475-477
  • Porra, R.J., Jones, O.T.G., Studies on ferrochelatase. I. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract (1963) Biochem. J., 87, pp. 181-185
  • Potter, C.L., Sipes, G., Russell, D.H., Inhibition of ornithine decarboxylase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (1982) Biochem. Pharmacol., 31, pp. 3367-3371
  • Preisegger, K.H., Factor, V.M., Fuchsbichler, A., Stumptner, C., Denk, H., Thorgeirsson, S.S., Atypical ductular proliferation and its inhibition by transforming growth factor beta 1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease (1999) Lab. Invest., 79, pp. 103-109
  • Raunio, H., Pelkonen, O., Effect of polycyclic aromatic compounds and phorbol esters on ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in mouse liver (1983) Cancer Res., 43, pp. 782-786
  • Rios de Molina, M.C., Taira, M.C., San Martin de Viale, L.C., Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. Studies on the properties (1989) Int. J. Biochem., 21, pp. 219-225
  • San Martín de Viale, L.C., Viale, A., Nacht, S., Grinstein, M., Experimental porphyria induced in rats by hexachlorobenzene. A study of the porphyrin excreted by urine (1970) Clin. Chim. Acta, 28, pp. 13-23
  • San Martín de Viale, L.C., Ríos de Molina, M., Del, C., Wainstok de Calmanovici, R., Tomio, J.M., Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene-induced porphyria (1977) Biochem. J., 168, pp. 393-400
  • Sanchez, C.P., González, N.S., Algranati, I.D., Stable ornithine decarboxylase in promastigotes of Leishmaina mexicana mexicana (1989) Biochem. Biophys. Res. Commun., 161, pp. 754-761
  • Smith, A.G., De Matteis, F., Drugs and the hepatic porphyrias (1980) Clinics Haematol., 9, pp. 399-425
  • Stewart, F.P., Manson, M.M., Cabral, J.R.P., Smith, A.G., Hexachlorobenzene as a promoter of diethylnitrosamine-initiated hepatocarcinogenesis in rats and comparison with induction of porphyria (1989) Carcinogenesis, 10, pp. 1225-1230
  • Stumptner, C., Bishr Omary, M., Fickert, P., Denk, H., Zatloukal, K., Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in Mallory body mouse model (2000) Am. J. Pathol., 156, pp. 77-90
  • Stumptner, C., Fuchsbichler, A., Lehner, M., Zatloukal, K., Denk, H., Sequence of events in the assembly of Mallory body components in mouse liver: Clues to the pathogenesis and significance of Mallory body formation (2001) J. Hepatol., 34, pp. 665-675
  • Tabor, C.W., Tabor, H., Polyamines (1984) Ann. Rev. Biochem., 53, pp. 749-790
  • Tephly, T.R., Gibbs, A.H., Ingall, G., De Matteis, F., Studies on the mechanism of experimental porphyria and ferrochelatase inhibition produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (1980) Int. J. Biochem., 12, pp. 993-998
  • Thomas, T., MacKenzie, S.A., Gallo, M.A., Regulation of polyamine biosynthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1990) Toxicol. Lett., 53, pp. 315-325
  • Varone, C.L., Giono, L.E., Ochoa, A., Zakin, M.M., Canepa, E.T., Transcriptional regulation of 5-aminolevulinate synthase by phenobarbital and cAMP-dependent protein kinase (1999) Arch. Biochem. Biophys., 372, pp. 261-270
  • Wainstok de Calmanovici, R., Billi de Catabbi, S.C., Aldonatti, C., San Martín de Viale, L.C., Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria (1989) Int. J. Biochem., 21, pp. 377-381
  • Wainstok de Calmanovici, R., Cochón, A.C., Aldonatti, C., Cabral, J.R.P., San Martín de Viale, L.C., Sex comparison of heme pathway in rats bearing hepatic tumors (1991) Tumori, 77, pp. 379-384
  • Wainstok de Calmanovici, R., Rios de Molina, M., Del, C., Taira de Yamasato, M.C., Tomio, J.M., San Martín de Viale, L.C., Mechanism of HCB-induced porphyria in rats. Effect of phenobarbitone pretreatment (1984) Biochem. J., 218, pp. 753-763
  • Zatloukal, K., Stumptner, C., Lehner, M., Denk, H., Baribault, H., Eshkind, L.G., Franke, W.W., Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies (2000) Am. J. Pathol., 156, pp. 1263-1274

Citas:

---------- APA ----------
Cochón, A.C., González, N. & San Martín De Viale, L.C. (2002) . Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism. Toxicology, 176(3), 209-219.
http://dx.doi.org/10.1016/S0300-483X(02)00145-2
---------- CHICAGO ----------
Cochón, A.C., González, N., San Martín De Viale, L.C. "Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism" . Toxicology 176, no. 3 (2002) : 209-219.
http://dx.doi.org/10.1016/S0300-483X(02)00145-2
---------- MLA ----------
Cochón, A.C., González, N., San Martín De Viale, L.C. "Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism" . Toxicology, vol. 176, no. 3, 2002, pp. 209-219.
http://dx.doi.org/10.1016/S0300-483X(02)00145-2
---------- VANCOUVER ----------
Cochón, A.C., González, N., San Martín De Viale, L.C. Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism. Toxicology. 2002;176(3):209-219.
http://dx.doi.org/10.1016/S0300-483X(02)00145-2