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Abstract:

OBJECTIVE: To evaluate the presence of circulating immunoglobulins that inhibit FSH binding to its receptor (Ig-FSHR) in patients with premature ovarian failure (POF). DESIGN Non-randomized study. Blood sampling for determination of circulating immunoglobulins. PATIENTS: Two hundred and forty-seven patients with POF and 60 normally menstruating women (controls). MEASUREMENTS: Circulating immunoglobulins that inhibit FSH binding to its receptor were assessed by FSH-binding inhibition assay. RESULTS: Twenty-three out of 247 women with POF presented circulating immunoglobulins that inhibit FSH binding to its receptor. These patients had been previously diagnosed as ROS. Sixty control subjects proved negative. CONCLUSION: Determination of the presence of circulating immunoglobulins that inhibit FSH binding to its receptor could be instrumental in diagnosing the gonadotropin resistance ovary syndrome.

Registro:

Documento: Artículo
Título:Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?
Autor:Chiauzzi, V.A.; Bussmann, L.; Calvo, J.C.; Sundblad, V.; Charreau, E.H.
Filiación:Inst. de Biol. y Med. Experimental, Buenos Aires, Argentina
Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Inst. de Biol. y Med. Experimental, Vuelta de Obligado 2490, C1428ADN, Buenos Aires, Argentina
Palabras clave:follitropin; follitropin receptor; immunoglobulin G; adolescent; adult; animal tissue; article; binding affinity; binding assay; controlled study; diagnostic accuracy; diagnostic error; diagnostic test; diagnostic value; female; follitropin blood level; hormone binding; human; immunoglobulin blood level; major clinical study; nonhuman; premature ovarian failure; priority journal; rat; resistant ovary syndrome; Adolescent; Adult; Biological Markers; Case-Control Studies; Female; Follicle Stimulating Hormone; Humans; Immunoglobulins; Middle Aged; Ovarian Failure, Premature; Predictive Value of Tests; Receptors, FSH
Año:2004
Volumen:61
Número:1
Página de inicio:46
Página de fin:54
DOI: http://dx.doi.org/10.1111/j.1365-2265.2004.02054.x
Título revista:Clinical Endocrinology
Título revista abreviado:Clin. Endocrinol.
ISSN:03000664
CODEN:CLENA
CAS:follitropin, 9002-68-0; immunoglobulin G, 97794-27-9; Biological Markers; Follicle Stimulating Hormone, 9002-68-0; Immunoglobulins; Receptors, FSH
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03000664_v61_n1_p46_Chiauzzi

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Citas:

---------- APA ----------
Chiauzzi, V.A., Bussmann, L., Calvo, J.C., Sundblad, V. & Charreau, E.H. (2004) . Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?. Clinical Endocrinology, 61(1), 46-54.
http://dx.doi.org/10.1111/j.1365-2265.2004.02054.x
---------- CHICAGO ----------
Chiauzzi, V.A., Bussmann, L., Calvo, J.C., Sundblad, V., Charreau, E.H. "Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?" . Clinical Endocrinology 61, no. 1 (2004) : 46-54.
http://dx.doi.org/10.1111/j.1365-2265.2004.02054.x
---------- MLA ----------
Chiauzzi, V.A., Bussmann, L., Calvo, J.C., Sundblad, V., Charreau, E.H. "Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?" . Clinical Endocrinology, vol. 61, no. 1, 2004, pp. 46-54.
http://dx.doi.org/10.1111/j.1365-2265.2004.02054.x
---------- VANCOUVER ----------
Chiauzzi, V.A., Bussmann, L., Calvo, J.C., Sundblad, V., Charreau, E.H. Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?. Clin. Endocrinol. 2004;61(1):46-54.
http://dx.doi.org/10.1111/j.1365-2265.2004.02054.x