González, B.; Torres, O.V.; Jayanthi, S.; Gomez, N.; Sosa, M.H.; Bernardi, A.; Urbano, F.J.; García-Rill, E.; Cadet, J.-L.; Bisagno, V."The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors" (2019) Progress in Neuro-Psychopharmacology and Biological Psychiatry. 88:222-234
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METH use causes neuroadaptations that negatively impact the prefrontal cortex (PFC) leading to addiction and associated cognitive decline in animals and humans. In contrast, modafinil enhances cognition by increasing PFC function. Accumulated evidence indicates that psychostimulant drugs, including modafinil and METH, regulate gene expression via epigenetic modifications. In this study, we measured the effects of single-dose injections of modafinil and METH on the protein levels of acetylated histone H3 (H3ac) and H4ac, deacetylases HDAC1 and HDAC2, and of the NMDA subunit GluN1 in the medial PFC (mPFC) of mice euthanized 1 h after drug administration. To test if dopamine (DA) receptors (DRs) participate in the biochemical effects of the two drugs, we injected the D1Rs antagonist, SCH23390, or the D2Rs antagonist, raclopride, 30 min before administration of METH and modafinil. We evaluated each drug effect on glutamate synaptic transmission in D1R-expressing layer V pyramidal neurons. We also measured the enrichment of H3ac and H4ac at the promoters of several genes including DA, NE, orexin, histamine, and glutamate receptors, and their mRNA expression, since they are responsive to chronic modafinil and METH treatment. Acute modafinil and METH injections caused similar effects on total histone acetylation, increasing H3ac and decreasing H4ac, and they also increased HDAC1, HDAC2 and GluN1 protein levels in the mouse mPFC. In addition, the effects of the drugs were prevented by pre-treatment with D1Rs and D2Rs antagonists. Specifically, the changes in H4ac, HDAC2, and GluN1 were responsive to SCH23390, whereas those of H3ac and GluN1 were responsive to raclopride. Whole-cell patch clamp in transgenic BAC-Drd1a-tdTomato mice showed that METH, but not modafinil, induced paired-pulse facilitation of EPSCs, suggesting reduced presynaptic probability of glutamate release onto layer V pyramidal neurons. Analysis of histone 3/4 enrichment at specific promoters revealed: i) distinct effects of the drugs on histone 3 acetylation, with modafinil increasing H3ac at Drd1 and Adra1b promoters, but METH increasing H3ac at Adra1a; ii) distinct effects on histone 4 acetylation enrichment, with modafinil increasing H4ac at the Drd2 promoter and decreasing it at Hrh1, but METH increasing H4ac at Drd1; iii) comparable effects of both psychostimulants, increasing H3ac at Drd2, Hcrtr1, and Hrh1 promoters, decreasing H3ac at Hrh3, increasing H4ac at Hcrtr1, and decreasing H4ac at Hcrtr2, Hrh3, and Grin1 promoters. Interestingly, only METH altered mRNA levels of genes with altered histone acetylation status, inducing increased expression of Drd1a, Adra1a, Hcrtr1, and Hrh1, and decreasing Grin1. Our study suggests that although acute METH and modafinil can both increase DA neurotransmission in the mPFC, there are similar and contrasting epigenetic and transcriptional consequences that may account for their divergent clinical effects. © 2018


Documento: Artículo
Título:The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors
Autor:González, B.; Torres, O.V.; Jayanthi, S.; Gomez, N.; Sosa, M.H.; Bernardi, A.; Urbano, F.J.; García-Rill, E.; Cadet, J.-L.; Bisagno, V.
Filiación:Instituto de Investigaciones Farmacológicas (Universidad de Buenos Aires – Consejo Nacional de Investigaciones Científicas y Técnicas), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Department of Behavioral Sciences, San Diego Mesa College, San Diego, California, United States
Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, Baltimore, MD, United States
Laboratorio de Fisiología y Biología Molecular, Instituto de Fisiología, Biología Molecular y Neurociencias (Universidad de Buenos Aires – Consejo Nacional de Investigaciones Científicas y Técnicas), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States
Palabras clave:Dopamine receptors; Glutamate; Histone acetylation; Methamphetamine; Modafinil; Prefrontal cortex; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate; biological marker; dopamine receptor; glutamic acid; histone deacetylase 1; histone deacetylase 2; histone H3; histone H4; messenger RNA; methamphetamine; modafinil; n methyl dextro aspartic acid; n methyl dextro aspartic acid GluN1; raclopride; unclassified drug; benzazepine derivative; central stimulant agent; dopamine receptor; dopamine receptor stimulating agent; histone; histone deacetylase 1; methamphetamine; modafinil; raclopride; receptor; Adra1a gene; Adra1b gene; animal cell; animal experiment; animal tissue; Article; controlled study; DA gene; Drd1 gene; Drd2 gene; epigenetics; excitatory postsynaptic potential; gene; gene expression; glutamate receptor gene; glutamatergic synapse; Grin1 gene; Hcrtr1 gene; Hcrtr2 gene; histamine gene; histone acetylation; Hrh1 gene; Hrh3 gene; male; medial prefrontal cortex; mouse; NE gene; neurotransmission; nonhuman; orexin gene; promoter region; protein analysis; protein expression; protein function; pyramidal nerve cell; synaptic transmission; whole cell patch clamp; animal; C57BL mouse; chromatin immunoprecipitation; cytology; drug effect; genetic epigenesis; genetics; metabolism; nerve cell; patch clamp technique; physiology; prefrontal cortex; transgenic mouse; Animals; Benzazepines; Central Nervous System Stimulants; Chromatin Immunoprecipitation; Dopamine Agents; Epigenesis, Genetic; Excitatory Postsynaptic Potentials; Histone Deacetylase 1; Histones; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Modafinil; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Raclopride; Receptors, Biogenic Amine; Receptors, Dopamine
Página de inicio:222
Página de fin:234
Título revista:Progress in Neuro-Psychopharmacology and Biological Psychiatry
Título revista abreviado:Prog. Neuro-Psychopharmacol. Biol. Psychiatry
CAS:8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate, 87134-87-0; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; methamphetamine, 28297-73-6, 51-57-0, 537-46-2, 7632-10-2; modafinil, 68693-11-8; n methyl dextro aspartic acid, 6384-92-5; raclopride, 84225-95-6; histone, 9062-68-4; Benzazepines; Central Nervous System Stimulants; Dopamine Agents; Histone Deacetylase 1; Histones; Methamphetamine; Modafinil; Raclopride; Receptors, Biogenic Amine; Receptors, Dopamine; SCH 23390


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---------- APA ----------
González, B., Torres, O.V., Jayanthi, S., Gomez, N., Sosa, M.H., Bernardi, A., Urbano, F.J.,..., Bisagno, V. (2019) . The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 88, 222-234.
---------- CHICAGO ----------
González, B., Torres, O.V., Jayanthi, S., Gomez, N., Sosa, M.H., Bernardi, A., et al. "The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors" . Progress in Neuro-Psychopharmacology and Biological Psychiatry 88 (2019) : 222-234.
---------- MLA ----------
González, B., Torres, O.V., Jayanthi, S., Gomez, N., Sosa, M.H., Bernardi, A., et al. "The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors" . Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 88, 2019, pp. 222-234.
---------- VANCOUVER ----------
González, B., Torres, O.V., Jayanthi, S., Gomez, N., Sosa, M.H., Bernardi, A., et al. The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 2019;88:222-234.