Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Discrimination surfaces are here introduced as a diagnostic tool for localizing brain regions where discrimination between diseased and nondiseased participants is higher. To estimate discrimination surfaces, we introduce a Mann-Whitney type of statistic for random fields and present large-sample results characterizing its asymptotic behavior. Simulation results demonstrate that our estimator accurately recovers the true surface and corresponding interval of maximal discrimination. The empirical analysis suggests that in the anterior region of the brain, schizophrenic patients tend to present lower local asymmetry scores in comparison with participants in the control group. Copyright © 2018 John Wiley & Sons, Ltd.

Registro:

Documento: Artículo
Título:Discrimination surfaces with application to region-specific brain asymmetry analysis
Autor:Martos, G.; de Carvalho, M.
Filiación:Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina
School of Mathematics, The University of Edinburgh, Edinburgh, United Kingdom
Palabras clave:conditional area under the curve; distance to symmetry; Mann-Whitney statistic; neuroanatomical asymmetry; receiver operating characteristic; schizophrenia
Año:2018
Volumen:37
Número:11
Página de inicio:1859
Página de fin:1873
DOI: http://dx.doi.org/10.1002/sim.7611
Título revista:Statistics in Medicine
Título revista abreviado:Stat. Med.
ISSN:02776715
CODEN:SMEDD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02776715_v37_n11_p1859_Martos

Referencias:

  • Galaburda, A.M., LeMay, M., Kemper, T.L., Geschwind, N., Right-left asymmetrics in the brain (1978) Science, 199, pp. 852-856
  • Springer, S.P., Deutsch, G., (1998) Left Brain, Right Brain: Perspectives from Cognitive Neuroscience, , 5th ed., New York, Freeman
  • Toga, A.W., Thompson, P.M., Mapping brain asymmetry (2003) Nat Rev Neurosci, 4, pp. 37-48
  • Rogers, L.J., Vallortigara, G., Andrew, R.J., (2013) Divided Brains: The Biology and Behaviour of Brain Asymmetries, , Cambridge UK, Cambridge University Press
  • Brignell, C.J., Dryden, I.L., Gattone, S.A., Park, B., Leask, S., Browne, W.J., Flynn, S., Surface shape analysis with an application to brain surface asymmetry in schizophrenia (2010) Biostatistics, 11, pp. 609-630
  • Luchins, D.J., Weinberger, D.R., Wyatt, R.J., Schizophrenia: evidence of a subgroup with reversed cerebral asymmetry (1979) Arch Gen Psychiatry, 36, pp. 1309-1311
  • Harrison, P.J., The neuropathology of schizophrenia: a critical review of the data and their interpretation (1999) Brain, 122, pp. 593-624
  • Shenton, M.E., Dickey, C.C., Frumin, M., McCarley, R.W., A review of MRI findings in schizophrenia (2001) Schizophrenia Res, 49, pp. 1-52
  • Csernansky, J.G., Gillespie, S.K., Dierker, D.L., Anticevic, A., Wang, L., Barch, D.M., Van Essen, D.C., Symmetric abnormalities in sulcal patterning in schizophrenia (2008) Neuroimage, 43, pp. 440-446
  • Ribolsi, M., Daskalakis, Z.J., Siracusano, A., Koch, G., Abnormal asymmetry of brain connectivity in schizophrenia (2014) Front Hum Neurosci, 8, pp. 1-11
  • Narr, K.L., Bilder, R.M., Luders, E., Thompson, P.M., Woods, R.P., Robinson, D., Szeszko, P.R., Toga, A.W., Asymmetries of cortical shape: effects of handedness, sex and schizophrenia (2007) Neuroimage, 34, pp. 939-948
  • Inácio de Carvalho, V., Jara, A., Hanson, T.E., de Carvalho, M., Bayesian nonparametric ROC regression modeling (2013) Bayesian Anal, 8, pp. 623-646
  • Inácio de Carvalho, V., de Carvalho, M., Alonzo, T.A., González-Manteiga, W., Functional covariate-adjusted partial area under the specificity-ROC curve with an application to metabolic syndrome diagnosis (2016) Ann Appl Stat, 10, pp. 1472-1495
  • Bandos, A., Rockette, H.E., Song, T., Gur, D., Area under the free-response ROC curve (FROC) and a related summary index (2009) Biometrics, 65, pp. 247-256
  • Ferraty, F., Vieu, P., (2006) Nonparametric Functional Data Analysis: Theory and Practice, , New York, Springer
  • Ramsay, J.O., (2006) Functional Data Analysis, , New York, Wiley
  • Sørensen, H., Goldsmith, J., Sangalli, L.M., An introduction with medical applications to functional data analysis (2013) Stat Med, 32, pp. 5222-5240
  • Talairach, P., Tournoux, J., (1988) A Stereotactic Coplanar Atlas of the Human Brain, , New York, Thieme
  • Dryden, I.L., (2017) Shapes Package, , Vienna, R Foundation for Statistical Computing
  • Pepe, M.S., (2003) The Statistical Evaluation of Medical Tests for Classification and Prediction, , Oxford UK, Oxford University Press
  • Oertel-Knöchel, V., Linden, D.E.J., Cerebral asymmetry in schizophrenia (2011) Neuroscientist, 17, pp. 456-467
  • Marron, J.S., Discussion of “Inference for Density Families using Functional Principal Component Analysis (2001) J Am Stat Assoc, 96, pp. 532-533
  • Hsieh, F., Turnbull, B.W., Nonparametric and semiparametric estimation of the receiver operating characteristic curve (1996) Ann Stat, 24, pp. 25-40
  • Youden, W.J., Index for rating diagnostic tests (1950) Cancer, 3, pp. 32-35
  • Lausen, B., Schumacher, M., Maximally selected rank statistics (1992) Biometrics, 48, pp. 73-85
  • Hothorn, T., Lausen, B., On the exact distribution of maximally selected rank statistics (2003) Comput Stat Data Anal, 43, pp. 121-137
  • Hothorn, T., Zeileis, A., Generally maximally selected statistics (2008) Biometrics, 64, pp. 1263-1269
  • Inácio de Carvalho, V., de Carvalho, M., Branscum, A., Nonparametric Bayesian covariate-adjusted estimation of the Youden index (2017) Biometrics, 73, pp. 1279-1288
  • Miller, M., Banerjee, A., Christensen, G., Joshi, S., Khaneja, N., Grenander, U., Matejic, L., Statistical methods in computational anatomy (1997) Stat Meth Med Res, 6, pp. 267-299
  • Pennec, X., Intrinsic statistics on Riemannian manifolds: basic tools for geometric measurements (2006) J Math Imag Vis, 25, pp. 127-154
  • Embrechts, P., Klüppelberg, C., Mikosch, T., (1997) Modelling Extremal Events for Insurance and Finance, , New York, Springer
  • Newey, W.K., McFadden, D., Large sample estimation and hypothesis testing (1994) Handbook of Econometrics, 4, pp. 2111-2245. , Amsterdam, Elsevier, -

Citas:

---------- APA ----------
Martos, G. & de Carvalho, M. (2018) . Discrimination surfaces with application to region-specific brain asymmetry analysis. Statistics in Medicine, 37(11), 1859-1873.
http://dx.doi.org/10.1002/sim.7611
---------- CHICAGO ----------
Martos, G., de Carvalho, M. "Discrimination surfaces with application to region-specific brain asymmetry analysis" . Statistics in Medicine 37, no. 11 (2018) : 1859-1873.
http://dx.doi.org/10.1002/sim.7611
---------- MLA ----------
Martos, G., de Carvalho, M. "Discrimination surfaces with application to region-specific brain asymmetry analysis" . Statistics in Medicine, vol. 37, no. 11, 2018, pp. 1859-1873.
http://dx.doi.org/10.1002/sim.7611
---------- VANCOUVER ----------
Martos, G., de Carvalho, M. Discrimination surfaces with application to region-specific brain asymmetry analysis. Stat. Med. 2018;37(11):1859-1873.
http://dx.doi.org/10.1002/sim.7611