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Abstract:

In normal settings, our brain is able to update its stored representations in content, strength, and/or expectations by the memory reconsolidation process. Thus, a reactivated memory enters in a transient labile state (destabilization) followed by a re-stabilization phase in order to persist (memory reconsolidation). Cognitive neuroscience and its insight into psychiatric problems attributed a close relationship between memory (formation, maintenance, and utilization) and several mental disorders. In this framework, the reconsolidation process could be not only the mechanism for maintenance of some psychopathologies, but also open a novel therapeutic window. Here we aim to integrate recent experimental and theoretical research on memory reconsolidation and anxiety disorders maintenance. We propose a bayesian-like model about anxiety disorders persistence and postulate a new theoretical framework for how anxiety disorders are maintained through impaired memory updating due to a dysfunctional prediction error minimization strategy and anticipatory responses to threat. © 2017

Registro:

Documento: Artículo
Título:Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders
Autor:Fernández, R.S.; Pedreira, M.E.; Boccia, M.M.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. II, 2do piso, Buenos Aires, Argentina
Laboratorio de Neurofarmacología de los Procesos de Memoria, Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 5to piso, Buenos Aires, Argentina
Palabras clave:Anxiety; Bayesian learning; Learning models; Memory reconsolidation; Memory schema; Mental disorders; anxiety disorder; attentional bias; Bayesian learning; conceptual framework; human; memory; memory consolidation; memory reconsolidation; prediction; recall; Review; state dependent learning; threat; translational research; animal; anxiety disorder; memory consolidation; pathophysiology; physiology; theoretical model; Animals; Anxiety Disorders; Humans; Memory Consolidation; Models, Theoretical
Año:2017
Volumen:57
Página de inicio:45
Página de fin:58
DOI: http://dx.doi.org/10.1016/j.cpr.2017.08.004
Título revista:Clinical Psychology Review
Título revista abreviado:Clin. Psychol. Rev.
ISSN:02727358
CODEN:CPSRD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02727358_v57_n_p45_Fernandez

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Citas:

---------- APA ----------
Fernández, R.S., Pedreira, M.E. & Boccia, M.M. (2017) . Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders. Clinical Psychology Review, 57, 45-58.
http://dx.doi.org/10.1016/j.cpr.2017.08.004
---------- CHICAGO ----------
Fernández, R.S., Pedreira, M.E., Boccia, M.M. "Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders" . Clinical Psychology Review 57 (2017) : 45-58.
http://dx.doi.org/10.1016/j.cpr.2017.08.004
---------- MLA ----------
Fernández, R.S., Pedreira, M.E., Boccia, M.M. "Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders" . Clinical Psychology Review, vol. 57, 2017, pp. 45-58.
http://dx.doi.org/10.1016/j.cpr.2017.08.004
---------- VANCOUVER ----------
Fernández, R.S., Pedreira, M.E., Boccia, M.M. Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders. Clin. Psychol. Rev. 2017;57:45-58.
http://dx.doi.org/10.1016/j.cpr.2017.08.004