Artículo

Saravia, F.E.; Beauquis, J.; Revsin, Y.; Homo-Delarche, F.; De Kloet, E.R.; De Nicola, A.F. "Hippocampal neuropathology of diabetes mellitus is relieved by estrogen treatment" (2006) Cellular and Molecular Neurobiology. 26(4-6):943-957
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Abstract:

1. A recently recognized complication of uncontrolled diabetes mellitus is the encephalopathy involving, among other regions, the hippocampus. Since estrogens bring neuroprotection in cases of brain injury and degenerative diseases, we have studied if estradiol (E2) administration counteracts some hippocampal abnormalities of streptozotocin (STZ)-diabetic adult mice. 2. We first report the ability of E2 to modulate neurogenesis in the dentate gyrus (DG) and subventricular zone (SVZ) of diabetic mice. Using bromodeoxyuridine (BrdU) to label newly generated cells, a strong reduction in cell proliferation was obtained in DG and SVZ of mice sacrificed 20 days after STZ administration. The reduction was completely relieved by 10 days of E2 pellet implantation, which increased 30-fold the circulating E2 levels. 3. Diabetic mice also showed abnormal expression of astrocyte markers in hippocampus. Thus, increased number of GFAP+ cells, indicative of astrogliosis, and increased number of apolipoprotein-E (Apo-E)+ astrocytes, a marker of ongoing neuronal dysfunction, was found in stratum radiatum below the CA1 hippocampal subfield of diabetic mice. Both parameters were reverted to normal by the E2 regime that upregulated cell proliferation. 4. The studies demonstrated that hippocampal neuropathology of uncontrolled diabetes is a reversible condition and sensitive to estrogen treatment. Studies in animal models may open up new venues for understanding the beneficial role of steroid hormones in diabetic encephalopathy. © 2006 Springer Science+Business Media, Inc.

Registro:

Documento: Artículo
Título:Hippocampal neuropathology of diabetes mellitus is relieved by estrogen treatment
Autor:Saravia, F.E.; Beauquis, J.; Revsin, Y.; Homo-Delarche, F.; De Kloet, E.R.; De Nicola, A.F.
Filiación:Laboratory of Neuroendocrine Biochemistry, Instituto de Biología y Medicina Experimental, Department of Biochemistry, Obligado 2490, 1428 Buenos Aires, Argentina
CNRS UMR 7059, Université Paris 7/D, Diderot, Paris, France
Department of Medical Pharmacology, Leiden University, Leiden, Netherlands
Instituto Universitario de Ciencias de la Salud, Fundación H.A. Barceló, Buenos Aires, Argentina
Palabras clave:Apolipoprotein E; Astrocytosis; Diabetes mellitus; Estrogens; Hippocampus; Neurogenesis; apolipoprotein E; estradiol; glial fibrillary acidic protein; animal; article; astrocyte; C57BL mouse; cell proliferation; comparative study; diabetic neuropathy; drug effect; evaluation; experimental diabetes mellitus; hippocampus; male; metabolism; mouse; pathology; Animals; Apolipoproteins E; Astrocytes; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Estradiol; Glial Fibrillary Acidic Protein; Hippocampus; Male; Mice; Mice, Inbred C57BL
Año:2006
Volumen:26
Número:4-6
Página de inicio:943
Página de fin:957
DOI: http://dx.doi.org/10.1007/s10571-006-9096-y
Título revista:Cellular and Molecular Neurobiology
Título revista abreviado:Cell. Mol. Neurobiol.
ISSN:02724340
CODEN:CMNED
CAS:estradiol, 50-28-2; Apolipoproteins E; Estradiol, 50-28-2; Glial Fibrillary Acidic Protein
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02724340_v26_n4-6_p943_Saravia

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Citas:

---------- APA ----------
Saravia, F.E., Beauquis, J., Revsin, Y., Homo-Delarche, F., De Kloet, E.R. & De Nicola, A.F. (2006) . Hippocampal neuropathology of diabetes mellitus is relieved by estrogen treatment. Cellular and Molecular Neurobiology, 26(4-6), 943-957.
http://dx.doi.org/10.1007/s10571-006-9096-y
---------- CHICAGO ----------
Saravia, F.E., Beauquis, J., Revsin, Y., Homo-Delarche, F., De Kloet, E.R., De Nicola, A.F. "Hippocampal neuropathology of diabetes mellitus is relieved by estrogen treatment" . Cellular and Molecular Neurobiology 26, no. 4-6 (2006) : 943-957.
http://dx.doi.org/10.1007/s10571-006-9096-y
---------- MLA ----------
Saravia, F.E., Beauquis, J., Revsin, Y., Homo-Delarche, F., De Kloet, E.R., De Nicola, A.F. "Hippocampal neuropathology of diabetes mellitus is relieved by estrogen treatment" . Cellular and Molecular Neurobiology, vol. 26, no. 4-6, 2006, pp. 943-957.
http://dx.doi.org/10.1007/s10571-006-9096-y
---------- VANCOUVER ----------
Saravia, F.E., Beauquis, J., Revsin, Y., Homo-Delarche, F., De Kloet, E.R., De Nicola, A.F. Hippocampal neuropathology of diabetes mellitus is relieved by estrogen treatment. Cell. Mol. Neurobiol. 2006;26(4-6):943-957.
http://dx.doi.org/10.1007/s10571-006-9096-y