Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

1. In a previous paper we reported evidence for the presence of mGnRH- and sGnRH-like peptides in the preoptic-hypothalamic region of the capybara Hydrochaeris hydrochaeris (Montaner et al., 1998). In that study, the presence of a cGnRH-II like molecule in olfactory bulb extracts was suggested. 2. The capybara, the largest living rodent in the world, belongs to the order Hystricomorpha, which is considered to be one of the oldest groups of rodents. Some authors consider that this group is the ancestor of all remaining rodents. 3. In this study we have characterized GnRH molecular variants found in extracts from the olfactory bulbs and the mesencephalic region of capybara. These regions represent the two GnRH neuronal systems: the terminal nerve-septopreoptic and the midbrain systems. 4. An indirect method combining reverse-phase high-performance liquid chromatography (RP- HPLC) and radioimmunoassay (RIA) was used to characterize GnRH variants. The analysis of both extracts with two different RIA systems revealed three immunoreactive GnRH peaks, coeluting with mGnRH, cIIGnRH, and sGnRH synthetic standards. These results were additionally supported by serial dilution studies with specific antisera. 5. To our knowledge this the first report on the presence of three GnRH variants in the brain of an eutherian mammal. These results suggest that, similarly to other vertebrates, the expression of multiple GnRH variants-may also be a common pattern in mammals.

Registro:

Documento: Artículo
Título:Differential distribution of gonadotropin-releasing hormone variants in the brain of Hydrochaeris hydrochaeris (mammalia, rodentia)
Autor:Montaner, A.D.; Affanni, J.M.; King, J.A.; Bianchini, J.J.; Tonarelli, G.; Somoza, G.M.
Filiación:Instituto de Neurociencia, Depto. de Ciencias Biológicas, Universidad de Buenos Aires (UBA), 1428 Buenos Aires, Argentina
Ctro. Invest. Cie. y T., Matteri y España, 3105 Diamante, Entre Ríos, Argentina
Depto. de Quim. Orgánica, Fac. de Bioquim. y Cie. Biol., Univ. Nac. Litoral, Paraje El Pozo, 3200 Santa Fe, Argentina
Department of Chemical Pathology, Univ. of Cape Town Medical School, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
Palabras clave:Capybara; Gonadotropin-releasing hormone; HPLC; Mammalian; Radioimmunoassay; gonadorelin; animal cell; animal tissue; article; female; genetic variability; hormone determination; male; mesencephalon; molecular biology; nonhuman; olfactory bulb; priority journal; protein expression; protein localization; reversed phase liquid chromatography; rodent; tissue distribution; Animals; Evolution; Female; Gonadotropin-Releasing Hormone; Male; Mesencephalon; Olfactory Bulb; Rodentia; Animalia; Eutheria; Hydrochaeris hydrochaeris; Hystricognathi; Mammalia; Rodentia; Vertebrata
Año:1999
Volumen:19
Número:5
Página de inicio:635
Página de fin:651
DOI: http://dx.doi.org/10.1023/A:1006936619129
Título revista:Cellular and Molecular Neurobiology
Título revista abreviado:Cell. Mol. Neurobiol.
ISSN:02724340
CODEN:CMNED
CAS:Gonadotropin-Releasing Hormone, 33515-09-2; LHRH, His(5)-Trp(7)-Tyr(8)-, 91097-16-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02724340_v19_n5_p635_Montaner

Referencias:

  • Amoss, M., Burgus, R., Blackwell, R., Vale, W., Fellows, R., Guillemin, R., Purification, aminoacid composition and N-terminus of the hypothalamic luteinizing hormone releasing factor (LRF) of ovine origin (1971) Biochem. Biophys. Res. Commun., 4, pp. 205-210
  • Dellovade, T., King, J.A., Millar, R.P., Rissman, E.F., Presence and differential distribution of distinct forms of immunoreactive gonadotropin-releasing hormone in the musk shrew brain (1993) Neuroendocrinology, 58, pp. 166-177
  • Fink, G., Gonadotropin secretion and its control. (1988) (1988) The Physiology of Reproduction, pp. 1349-1377. , Knobil, E., and Neill, J. (eds), Raven Press, New York
  • Gautron, J.P., Pattou, E., Bauer, K., Kordon, C., (Hydroxyproline9) luteinizing hormone-releasing hormone: A novel peptide in mammalian and frog hypothalamus (1991) Neurochem. Int., 18, pp. 221-235
  • Gothilf, Y., Mumoz-Cueto, J.A., Sargillo, C.A., Selmanoff, M., Chen, T.T., Kah, O., Elizur, A., Zohar, Y., Three forms of Gonadotropic-releasing hormone in a periciform fish (Spaurus aurata): Complementary deoxyribonucleic acid characterization and brain localization (1996) Biol. Reprod., 55, pp. 636-645
  • Hershkovitz, E., The resent mammals of the neotropical region: A zoogeographic and ecological review (1969) Q. Rev. Biol., 44, pp. 1-70
  • Jimenez-Linan, M., Rubin, B.S., King, J.C., Examination of guinea pig Luteinizing hormone-releasing hormone gene reveals a unique decapeptide and existence of two transcripts in the brain (1997) Endocrinology, 138, pp. 4123-4130
  • Kasten, T.L., White, S.A., Norton, T.T., Bond, C.T., Adelman, J.P., Fernald, R.D., Characterization of two new preproGnRH mRNAs in the tree shrew: First direct evidence for mesencephalic GnRH gene expression in a placental mammal (1996) Gen. Comp. Endocrinol, 104, pp. 7-19
  • King, J.A., Millar, R.P., Coordinated evolution of GnRHs and there receptors (1997) GnRH Neurons: Gene to Behavior, pp. 52-77. , Parhar, I. S., and Sakuma, Y. (eds.), Brain Shuppan, Tokyo, 1997
  • King, J.A., Mehl, A.E.I., Tyndale-Biscoe, C.H., Hinds, L., Millar, R.P., A second form of GnRH, with chicken GnRH II-like properties, occurs together with mammalian GnRH in marsupial brains (1989) Endocrinology, 125, pp. 2244-2252
  • King, J.A., Hinds, L.A., Mehl, A.E.I., Saunders, N.R., Millar, R.P., Chicken GnRH II occurs together with mammalian GnRH in South American species of marsupial (Monodelphis domestica) (1990) Peptides, 11, pp. 521-525
  • King, J.A., Steneveld, A.A., Curlewis, J.D., Rissman, E.F., Millar, R.P., Identification of chicken GnRH II in the brains of metatherian and early-evolved eutherian species of mammals (1994) Regul. Pept., 54, pp. 467-477
  • Lavocat, L., What is an hystricomorph (1974) Symp. Zool. Soc. Lond., 34, pp. 7-20
  • Lescheid, D.W., Terasawa, E., Abler, L.A., Urbanski, H.F., Warby, C.M., Millar, R.P., Sherwood, N.M., A second form of gonadotropin-releasing hormone (GnRH) with characteristics of chicken GnRH-II is present in the primate brain (1997) Endocrinology, 138, pp. 5618-5629
  • Matsuo, H., Baba, Y., Nair, R.M.G., Arimura, A., Schally, A.V., Structure of the porcine LH and FSH-releasing hormone. I. the proposed amino acid sequence (1971) Biochem. Biophys. Res. Commun., 43, pp. 1334-1339
  • Montaner, A.D., Somoza, G.M., King, J.A., Bianchini, J.J., Bolis, C.G., Affanni, J.M., Identification of GnRH variants (mGnRH and sGnRH) in the forebrain of Hydrochaeris hydrochaeris (Mammalia, Rodentia) (1997) Advances in Comparative Endocrinology. Proceedings of the XIII International Congress of Comparative Endocrinology, pp. 715-719. , Kawashima, S., and Kikuyama, S. (eds.), Monduzzi Editore, Bologna, Tome II
  • Montaner, A.D., Somoza, G.M., King, J.A., Bianchini, J.J., Bolis, C., Affanni, J.M., Chromatographic and immunological identification of GnRH (gonadotropin-releasing hormone) variants. Occurrence of mammalian and a salmon-like GnRH in the forebrain of an eutherian mammal (1998) Hydrochaeris Hydrochaeris (Mammalia, Rodentia). Regul. Pept., 73, pp. 197-204
  • Muske, L.E., Ontogeny, phylogeny and neuroanatomical organization of multiple molecular forms of GnRH (1997) GnRH Neurons: Gene to Behavior, pp. 145-180. , Parhar, I. S., and Sakuma, Y. (eds.), Brain Shuppan, Tokyo
  • Novacek, M.J., Mammalian phylogeny: Shaking the tree (1992) Nature, 365, pp. 121-125
  • Okuzawa, K., Amano, M., Kobayashi, M., Aida, K., Hanyu, I., Miyamoto, K., Differences in sGnRH and cGnRH-II contents in discrete brain areas of male and female rainbow trout according to age and stage of maturity (1990) Gen. Comp. Endocrinol., 80, pp. 116-126
  • Parhar, I.S., GnRH in tilapia: Three genes, three origins and their roles (1997) GnRH Neurons: Gene to Behavior, pp. 197-219. , Parhar, I. S. and Sakuma, Y. (eds.), Brain Shuppan, Tokyo
  • Patterson, B., Pascual, R., The fossil mammals fauna of South America (1972) Evolution, Mammals and Southern Continents, pp. 247-309. , Keast, A., Erk, F. C., and Glass, B. (eds.), University of New York Press, Albany
  • Redford, K.H., Eisenberg, J.F., (1992) Mammals of the Neotropics. the Southern Cone. Vol. 2. Chile, Argentina, Uruguay, Paraguay, 2, pp. 343-344. , University of Chicago Press, Chicago, London
  • Rissman, E.F., Alones, V.E., Craig-Veit, C.B., Millam, J.R., Distribution of chicken-II gonadotropin-releasing hormone in mammalian brain. J (1995) Comp. Neurol., 357, pp. 524-531
  • Sherwood, N.M., The evolution of gonadotropin-releasing hormone (1997) International Symposium on the Comparative Biology of GnRH Neurons, , Tokyo, Japan (abstract)
  • Sherwood, N., Zoeller, R.T., Moore, F.L., Multiple forms of gonadotropin-releasing hormone in amphibians brain (1986) Gen. Comp. Endocrinol., 61, pp. 313-322
  • Somoza, G.M., Stefano, A.V., D'Eramo, J.L., Canosa, L.F., Fridman, O., Immunoreactive GnRH suggesting a third form of GnRH in addition to cIIGnRH and sGnRH in the brain and pituitary gland of Prochilodus lineatus (Characiformes) (1994) Gen. Comp. Endocrinol., 94, pp. 44-52
  • Somoza, G.M., Paz, D.A., Stefano, A.V., Affanni, J.M., Identification of immunoreactive mammalian gonadotropin-releasing hormone in the brain of metamorphic larvae of Bufo arenarum Hensel (Amphibia: Anura) (1996) Int. J. Dev. Neurosci., 14, pp. 663-672
  • Stefano, A.V., Canosa, L.F., D'Eramo, J.L., Fridman, O., Affanni, J.M., Somoza, G.M., GnRH molecular variants in the brain and pituitary gland of pejerrey, Odontesthes bonariensis (Atheriniformes). Immunological and chromatographic evidence for the presence of a novel molecular variant (1997) Comp. Biochem. Physiol. C, 3, pp. 335-345
  • Terasawa, E., Quambeck, C., Two type of LHRH neurons in the forebrain of the rhesus monkey during embryonic development (1997) GnRH Neurons: Gene to Behavior, pp. 197-219. , Parhar, I. S., and Sakuma, Y. (eds.), Brain Shuppan, Tokyo
  • White, R.B., Eisen, J.A., Kasten, T.L., Fernald, R.D., Second gene for gonadotropin-releasing hormone in humans (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 305-309
  • Yamamoto, N., Oka, Y., Amano, M., Aida, K., Hasegawa, Y., Kawashima, S., Multiple gonadotropin-releasing hormone (GnRH)-Immunoreactive systems in the brain of the dwarf gourami, Colisa lalia: Immunohistochemistry and radioimmunoassay (1995) J. Comp. Neurol., 355, pp. 354-368
  • Yu, K.L., Sherwood, N.M., Peter, R.E., Differential distribution of two molecular forms of gonadotropin-releasing hormone in discrete brain areas of goldfish (Carassius auratus) (1988) Peptides, 9, pp. 625-630

Citas:

---------- APA ----------
Montaner, A.D., Affanni, J.M., King, J.A., Bianchini, J.J., Tonarelli, G. & Somoza, G.M. (1999) . Differential distribution of gonadotropin-releasing hormone variants in the brain of Hydrochaeris hydrochaeris (mammalia, rodentia). Cellular and Molecular Neurobiology, 19(5), 635-651.
http://dx.doi.org/10.1023/A:1006936619129
---------- CHICAGO ----------
Montaner, A.D., Affanni, J.M., King, J.A., Bianchini, J.J., Tonarelli, G., Somoza, G.M. "Differential distribution of gonadotropin-releasing hormone variants in the brain of Hydrochaeris hydrochaeris (mammalia, rodentia)" . Cellular and Molecular Neurobiology 19, no. 5 (1999) : 635-651.
http://dx.doi.org/10.1023/A:1006936619129
---------- MLA ----------
Montaner, A.D., Affanni, J.M., King, J.A., Bianchini, J.J., Tonarelli, G., Somoza, G.M. "Differential distribution of gonadotropin-releasing hormone variants in the brain of Hydrochaeris hydrochaeris (mammalia, rodentia)" . Cellular and Molecular Neurobiology, vol. 19, no. 5, 1999, pp. 635-651.
http://dx.doi.org/10.1023/A:1006936619129
---------- VANCOUVER ----------
Montaner, A.D., Affanni, J.M., King, J.A., Bianchini, J.J., Tonarelli, G., Somoza, G.M. Differential distribution of gonadotropin-releasing hormone variants in the brain of Hydrochaeris hydrochaeris (mammalia, rodentia). Cell. Mol. Neurobiol. 1999;19(5):635-651.
http://dx.doi.org/10.1023/A:1006936619129