Navegar

Colección

Datos Estadísticas

Artículo

Becú-Villalobos, D.; Iglesias, A.G.; Díaz-Torga, G.; Hockl, P.; Libertun, C. "Brain sexual differentiation and gonadotropins secretion in the rat" (1997) Cellular and Molecular Neurobiology. 17(6):699-715
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

1. The present work deals with sexual differences in gonadotropin regulation in the rat and the role of sexual organization of the hypothalamus in determining such differences. 2. Sex differences between male and female rats, with regard to their control of gonadotropin secretion, go beyond whether or not gonadotropins are released cyclically. Rats show additional sex differences (a) in the response of gonadotropins to removal and imposition of negative feedback signals and (b) in the ontogeny of gonadotropin regulation from birth to puberty. 3. There is a sensitive developmental period during which sexual differentiation of neural substrates proceeds irreversibly under the influence of gonadal hormones. In the rat this period starts a few days before birth and ends approximately 10 days after birth. Female rats treated during this sensitive period with androgens or estrogens will permanently lose the capacity to release GnRH in response to estrogenic stimulation. 4. Nevertheless although sexual differentiation is dramatically affected by events during the neonatal period, recent data question the 'critical' nature of this period, as it has been shown that testosterone can still act on neural substrates well beyond (15 to 30 days of age) the neonatal period to defeminize and masculinize endocrine and behavioral functions. 5. Furthermore, the capacity for the normal display of female sexual behavior and for the cyclic release of gonadotropins is not, as has been assumed, inherent to central nervous tissue but depends on active hormonal estrogenic induction during a sensitive period of development. 6. Besides, during differentiation of male sexual brain function estrogens may be supportive, rather than directive, to the primary action of androgens. 7. Serotonergic, noradrenergic, and opioid systems participate in the sexual dimorphism in gonadotropin control in adult rats. 8. The sex difference in the postcastration LH rise is dependent on the early sexual organization of the hypothalamus, even though in adulthood it can also be influenced by a variety of factors such as the stage of the estrous cycle, age of the animal, estradiol pretreatment, and history of release from feedback inhibition. 9. The characteristic pattern of gonadotropin secretion in the female infantile rat, which is sexually differentiatied, can be related to an increase in hypophyseal receptors coupled to an increase in the intracellular calcium response to GnRH. Such events depend on the sexual organization of the hypothalamus. In males the greater sensitivity to GnRH at 30 days is reflected in an increase in pituitary GnRH receptors but not in an increase in the magnitude of Ca2+ mobilization induced by GnRH, therefore it is probable that in this situation alternative second messengers may modulate high sensitivity. Neonatal androgenization of the hypothalamus may decrease the hypophyseal response to GnRH by an alteration in receptor concentration and signal transduction during the infantile period. 10. Finally, serotonergic, dopaminergic, opioid, and noradrenergic regulation of GnRH varies with increasing age, and the sexual organization of the hypothalamus by testosterone or estrogens is a determinant in such regulation.

Registro:

Documento: Artículo
Título:Brain sexual differentiation and gonadotropins secretion in the rat
Autor:Becú-Villalobos, D.; Iglesias, A.G.; Díaz-Torga, G.; Hockl, P.; Libertun, C.
Filiación:Inst. de Biol. y Med. Experimental, CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Brain sexual differentiation; Gonadotropin; Neurotransmitters; Ontogeny; androgen; estrogen; gonadorelin; gonadotropin; noradrenalin; opiate; serotonin; testosterone; adolescent; animal experiment; article; controlled study; feedback system; female; feminization; gonadotropin release; male; newborn; nonhuman; priority journal; puberty; rat; sex difference; sex differentiation; sexual behavior; sexual development; signal transduction; virilization; Animals; Brain; Female; Gonadotropins; Male; Rats; Sex Characteristics
Año:1997
Volumen:17
Número:6
Página de inicio:699
Página de fin:715
DOI: http://dx.doi.org/10.1023/A:1022542221535
Título revista:Cellular and Molecular Neurobiology
Título revista abreviado:Cell. Mol. Neurobiol.
ISSN:02724340
CODEN:CMNED
CAS:Gonadotropins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02724340_v17_n6_p699_BecuVillalobos

Referencias:

  • Aubert, M.L., Begeot, M., Winiger, B.P., Morel, G., Sizonenko, P.C., Dubois, P.M., Ontogeny of hypothalamic luteinizing hormone-releasing hormone (GnRH) and pituitary GnRH receptors in fetal and neonatal rats (1985) Endocrinology, 116, pp. 1565-1576
  • Ayoub, D.M., Greenough, W.T., Juraska, J.M., Sex differences in dendritic structure in the preoptic area of the juvenile macaque monkey brain (1983) Science, 219, pp. 197-198
  • Barraclough, C.A., Modifications in reproductive function after exposure to hormones during the prenatal and early postnatal period (1967) Neuroendocrinology, pp. 61-99. , Martini, L. and Ganong, W. F. (eds.), Academic Press, New York
  • Barraclough, C.A., Turgeon, J.L., Further studies of the hypothalamo-hypophysealgonadal axis of the androgen-sterilized rat (1974) Endocrinologie Sexuelle de la Periode Perinatale, pp. 339-357. , Forest, M. G. and Bertrand, J. (eds.), INSERM, Paris
  • Beck, W., Hancke, J.L., Wuttke, W., Increased sensitivity of dopaminergic inhibition of luteinizing hormone release in immature and castrated female rats (1978) Endocrinology, 102, pp. 837-843
  • Becú De Villalobos, D., Lacau De Mengido, I.M., Control hormonal del desarrollo puberal en la rata hembra (1990) Acta Physiol. Pharmacol. Latinoam., 40, p. 1
  • Becú De Villalobos, D., Lux, V.A.R., Lacau De Mengido, I.M., Libertun, C., Sexual differences in the serotoninergic control of prolactin and luteinizing hormone secretion in the rat (1984) Endocrinology, 115, pp. 84-89
  • Becú-Villalobos, D., Libertun, C., Ontogenesis of 3(H) serotonin binding sites in the hypothalamus of the female rat: Relation to serotonin induced LH release in moxestrol pretreated rats (1986) Dev. Brain Res., 25, pp. 111-116
  • Becú-Villalobos, D., Lacau De Mengido, I.M., Libertun, C., Developmental changes in FSH secretion induced by 5-hydroxytryptophan, naloxone and haloperidol in male and female rats (1989) Dev. Brain Res., 47, pp. 181-186
  • Becú-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., Ontogenic studies of the neural control of the adenohypophyseal hormones in the rat: Gonadotropins (1990) Cell. Mol. Neurobiol., 10, pp. 473-484
  • Becú-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., Sexual differentiation of the brain is involved in 5-hydroxytryptophan- and naloxone -induced FSH release in the infantile rat (1990) Neuroendocrinol. Lett., 12, pp. 435-442
  • Blank, M.S., Panerai, A.E., Friesen, H.G., Opioid peptides modulate luteinizing hormone secretion during sexual maturation (1979) Science, 203, pp. 1129-1131
  • Bloch, G.J., Mills, R., Prepubertal testosterone treatment of neonatally gonadectomized male rats: Defeminization and masculinization of behavioral and endocrine function in adulthood (1995) Neurosci. Biobehav. Rev., 19, pp. 187-200
  • Bloch, G.J., Mills, R., Gale, S., Prepubertal testosterone treatment of female rats: Defeminization of behavioral and endocrine function in adulthood (1995) Neurosci. Biobehav. Rev., 19, pp. 177-186
  • Bonsall, R.W., Zumpe, D., Michael, R.P., Comparisons of the nuclear uptake of 3-testosterone and its metabolites by the brain of male and female macaque fetuses at 122 days or gestation (1990) Neuroendocrinology, 51, pp. 474-480
  • Bourguignon, J.-P., Franchimont, P., Puberty related increase in episodic LHRH release from rat hypothalamus in vitro (1984) Endocrinology, 114, pp. 1941-1943
  • Campbell, C.S., Schwartz, N.B., Steroid feedback regulation of luteinizing hormone and follicle-stimulating hormone secretion rats in male and female rats (1977) J. Toxicol. Environ. Health, 3, pp. 61-95
  • Chan, V., Clayton, R., Knox, G., Catt, K.J., Ontogeny of pituitary GnRH receptors in the rat (1981) Endocrinology, 108, pp. 2086-2092
  • Chiappa, S.A., Fink, G., Releasing factor and hormonal changes in the hypothalamic-pituitary-gonadotrophin and -adrenocorticotrophin systems before and after birth and puberty in male, female and adrogenized female rats (1977) J. Endocrinol., 72, pp. 211-224
  • Clough, R.W., Hoffman, G.E., Sladek, C.D., Peripubertal development of noradrenergic stimulation of luteinizing hormone-releasing hormone neurosecretion in vitro (1988) Brain Res., 446, pp. 121-132
  • Dalkin, A.C., Bourne, G.A., Pieper, D.R., Regiani, S., Marshall, J.C., Pituitary and gonadal gonadotropin-releasing hormone receptors during sexual maturation in the rat (1981) Endocrinology, 108, pp. 1658-1664
  • Damassa, D.A., Rabii, J., Sawyer, C.H., Responses of serum LH and FSH to the removal of steroid feedback inhibition (1983) Neuroendocrinology, 37, pp. 122-130
  • Debeljuk, L., Arimura, A., Schally, A.V., Studies on the pituitary responsiveness to luteinizing hormone-releasing hormone (LHRH) in intact male rats at different ages (1972) Endocrinology, 90, pp. 585-589
  • Debeljuk, L., Arimura, A., Schally, A.V., Pituitary responsiveness to LH-releasing hormone in intact female rats at different ages (1972) Endocrinology, 90, p. 1499
  • Demling, J., Fuchs, E., Baumert, H., Wuttke, W., Preoptic catecholamine, GABA and glutamate release in ovariectomised and ovariectomised oestrogen-primed rat utilizing a push-pull cannula technique (1985) Neuroendocrinology, 41, pp. 212-218
  • DePaolo, L.V., Negro-Vilar, A., Estrogenic feminization of the LH response to orchidectomy in the rat: Evidence for a hypothalamic site of action (1982) Neuroendocrinology, 34, pp. 104-111
  • Diaz-Torga, G., Becú-Villalobos, D., Lacau De Mengido, I.M., Libertun, C., Sexual and ontogenic differences in K+ induced gonadotropins and prolactin release in vitro (1992) Dev. Brain Res., 70, pp. 103-108
  • Dohler, K.D., The pre- and postnatal influence of hormones and neurotransmitters on sexual differentiation of the mammalian hypothalamus (1991) Int. Rev. Cyt., 131, pp. 1-57
  • Dohler, K.D., Wuttke, W., Serum LH, FSH, prolactin and progesterone from birth to puberty in female and male rats (1974) Endocrinology, 94, pp. 1003-1008
  • DonCarlos, L.L., McAbee, M., Ramer-Quinn, D.S., Stancik, D.M., Estrogen receptor mRNA levels in the proptic area of neonatal rats are responsive to hormone manipulation (1995) Dev. Brain Res., 84, pp. 253-260
  • Dorner, G., Sexual differentiation of the brain (1981) Vit. Horm., 38, pp. 325-381
  • Duncan, J.A., Dalkin, A.C., Barkan, A., Regiani, S., Marshall, J.C., Gonadal regulation of pituitary gonadotropin-releasing hormone receptors during sexual maturation in the rat (1983) Endocrinology, 113, pp. 2238-12236
  • Dutlow, C.M., Rachman, J., Jacobs, T.W., Millar, R.P., Prepubertal increases in gonadotropin-releasing hormone mRNA, gonadotropin-releasing hormone precursor, and subsequent maturation of precursor processing in male rats (1992) J. Clin. Invest., 90, pp. 2496-2501
  • Dyer, R.G., Grossmann, R., Mansfield, D., Diez-Guerra, F.J., Ricknell, R.J., Hollingsworth, S., Opioid peptides inhibit noradrenergic transmission in the preoptic area to block LH secretion: Evidence from neonatally androgenized rats (1988) Brain Res. Bull., 20, pp. 721-727
  • Fink, G., Henderson, S.R., Steroids and pituitary responsiveness in female, androgenized female and male rats (1977) J. Endocrinol., 73, pp. 157-164
  • Frager, M., Duncan, J., Pieper, D., Tonetta, S., Marshall, J.C., Regulation of pituitary GnRH receptors by GnRH and gonadal steroids (1980) Clin. Res., 28, pp. 2591-2598
  • Gay, V.L., Midgley, A.R., Response of the adult rat to orchidectomy and ovariectomy as determined by LH radioimmunoassay (1969) Endocrinology, 84, pp. 1359-1364
  • Gay, V., Midgley, A.R., A sex-related pattern of gonadotropin secretion in the castrated rat: Effects of changing the inhibitory steroid on pituitary LH content (1977) Biol. Reprod., 16, pp. 527-535
  • Grady, R.R., Effect of neonatal treatment with the sex-opposite steroid on gonadotropin responsiveness in rats (1986) Neuroendocrinology, 43, pp. 322-330
  • Grossmann, R., Diez-Guerra, F.J., Mansfield, S., Dyer, R.G., Neonatal testosterone modifies LH secretion in the adult female rat by altering the opioid-noradrenergic interaction in the medial preoptic area (1987) Brain Res., 415, pp. 205-210
  • Hammer, R.P., The sex hormone-dependent development of opiate receptors in the rat medial preoptic area (1985) Brain Res., 360, pp. 65-74
  • Handa, R.J., Condon, T.P., Whitmoyer, D.I., Gorski, R.A., Gonadotropin secretion following intraventricular norepinephrine infusion into neonatally androgenised female rats (1986) Neuroendocrinology, 43, pp. 269-272
  • Hompes, P.G.A., Vermes, I., Tilders, F.J.H., Schoemaker, J., In vitro release of LHRH from the hypothalamus of female rats during prepubertal development (1982) Neuroendocrinology, 35, pp. 8-12
  • Hong, J.S., Yoshikawa, K., Lamartiniere, C.A., Sex-related difference in the rat pituitary (Met5)-enkephalin level altered by gonadectomy (1982) Brain Res., 251, pp. 380-383
  • Honma, K., Hohn, K.G., Wuttke, W., Involvement of catecholamines in eliciting LH peaks in 15-day-old female rats: Effects of treatment with prolactin (1979) Brain Res., 75, pp. 271-279
  • Ieri, T., Chen, H.T., Meites, J., Effects of morphine and naloxone on serum levels of luteinizing hormone and prolactin in prepubertal male and female rats (1979) Neuroendocrinology, 29, pp. 288-292
  • Jakubowski, M., Blum, M., Roberts, J.L., Postnatal development of gonadotropin-releasing hormone and cyclophilin gene expression in the female and male rat brain (1991) Endocrinology, 128, pp. 2702-2708
  • Justo, S.N., Rossano, G.L., Szwarcfarb, B., Rubio, M.C., Moguilevsky, J.A., Effect of serotoninergic system on FSH secretion in male and female rats: Evidence for stimulatory and inhibitory actions (1989) Neuroendocrinology, 50, pp. 382-386
  • Kalra, S.P., Kalra, P.S., Neural regulation of luteinizing hormone secretion in the rat (1981) Endocr. Rev., 4, pp. 311-351
  • Kalra, S.P., Kalra, P.S., Do testosterone and estradiol-17B enforce inhibition or stimulation of luteinizing hormone-releasing hormone secretion? (1989) Biol. Reprod., 41, pp. 559-570
  • Lacau De Mengido, I.M., Becú-Villalobos, D., Libertun, C., Sexual differences in the dopaminergic control of LH secretion in the developing rat (1987) Dev. Brain Res., 35, pp. 91-95
  • Lacau De Mengido, I.M., Becú-Villalobos, D., Diaz, G., Libertun, C., Chronic activation of dopamine receptors in the female infantile rat: Effect on hypophyseal hormones and on the onset of puberty (1989) Endocrinology, 124, pp. 746-753
  • Lacau-Mengido, I.M., Becú-Villalobos, D., Thyssen, S.M., Rey, E.B., Lux-Lantos, V.A.R., Libertun, C., Antidopaminergic-induced hypothalamic LHRH release and pituitary gonadotrophin secretion in 12 day-old female and male rats (1993) J. Neuroendocrinol., 5, pp. 705-709
  • Leadem, C.A., Kalra, S.P., Effects of endogenous opioid peptides and opiates on luteinising hormone and prolactin secretion in ovariectomised rats (1985) Neuroendocrinology, 41, pp. 342-352
  • Libertun, C., Timiras, P.S., Kragt, C.L., Sexual differences in the hypothalamic cholinergic system before and after puberty. Luducrory effect of testosterone (1973) Neuroendocrinology, 12, pp. 73-85
  • Lookingland, K.J., Wise, P.M., Barraclough, C.A., Failure of the hypothalamic noradrenergic system to function in androgen-sterilized rats (1981) Biol. Reprod., 27, pp. 268-281
  • Lookingland, K.J., Wise, P.M., Barraclough, C.A., Failure of the hypothalamic noradrenergic system to function in adult androgen-sterilized rats (1982) Biol. Reprod., 27, pp. 268-281
  • MacKinnon, P.C.B., Mattock, J., The effects of handling on episodic release of LH in immature rats (1976) Ann. Biol. Anim. Biophys., 16, pp. 345-348
  • MacKinnon, P.C.B., Mattock, J., Ter Haar, M.B., Serum gonadotropin levels during development in male, female, and androgenized female rats and the effect of general disturbance on high luteinizing hormone levels (1976) J. Endocrinol., 70, pp. 361-371
  • Mennin, S.P., Kubo, K., Gorski, R.A., Pituitary responsiveness to luteinizing hormone-releasing factor in normal and androgenized female rats (1974) Endocrinology, 95, pp. 412-416
  • Moguilevsky, J.A., Faigon, M.R., Scacchi, P., Szwarcfarb, B., Effect of castration on serum gonadotropin levels in androgenized male and female rats (1979) Neuroendocrinology, 29, pp. 323-328
  • Moguilevsky, J., Faigon, M.R., Scacchi, P., Szwarcfarb, B., Role of sexual differentiation of the hypothalamus in the differential effect of the serotoninergic system on LH in prepubertal male and female rats (1987) Neuroendocrinology, 45, pp. 274-277
  • Naish, S.J., Brawer, J., Robaire, B., Ruf, K.B., Changes in the dynamics of luteinizing hormone-releasing hormone-stimulated secretion of luteinizing hormone during sexual maturation of female rats (1986) Biol. Reprod., 34, pp. 549-557
  • Ojeda, S.R., Urbanski, H.F., Puberty in the rat (1994) The Physiology of Reproduction, pp. 363-409. , Knobil, E., and Neill, J. (eds.), Raven Press, New York
  • Ojeda, S.R., Jameson, H.E., Mc Cann, S.M., Developmental changes in pituitary responsiveness to luteinizing-hormone releasing hormone (LHRH) in the female rat: Ovarian adrenal influences during the infantile period (1977) Endocrinology, 100, pp. 440-451
  • Ortmann, O., Merelli, F., Stojilkovic, S.S., Schultz, K.D., Emons, G., Catt, K.J., Modulation of calcium signaling and LH secretion by progesterone in pituitary gonadotrophs and clonal pituitary cells (1994) J. Steroid Biochem. Mol. Biol., 48, pp. 47-54
  • Petersen, S.L., Barraclough, C.A., Effect of naloxone and morphine on LH and prolactin release in androgen-sterilized rats (1986) Neuroendocrinology, 44, pp. 84-88
  • Pinilla, L., Tena-Sempere, M., Aguilar, E., Effect of LHRH, naloxone and N-methyl-D-aspartic acid on serum gonadotropin concentrations in neonatally estrogenized female rats (1994) Neuroendocrinol, Lett., 16, pp. 233-239
  • Savoy-Moore, R.T., Schwartz, N.B., Duncan, J., Marshall, J.C., Pituitary gonadotropin-releasing hormone receptors during the rat estrous cycle (1980) Science, 209, pp. 942-944
  • Schulz, R., Wilhelm, A., Pirke, K.M., Herz, A., Sex-dependent endorphinergic and adrenergic control mechanisms of luteinizing hormone secretion in immature rats (1985) Acta Endocrinol., 109, pp. 198-203
  • Simerly, R.B., Swanson, L.W., Gorski, R.A., Demonstration of a sexual dimorphism in the distribution of serotonin immunoreactive fibers in the medial preoptic nucleus of the rat (1984) J. Comp. Neurol., 225, pp. 151-166
  • Steger, R.W., Morgen, W., Dopaminergic control of pituitary hormone release (1985) Handbook of Pharmacologic Methodologies for the Study of the Neuroendocrine System, pp. 65-108. , Steger, R. W. and Johns, A. (eds.), CRS Press, Boca Raton, FL
  • Stojilkovic, S.S., Reinhart, J., Catt, K.J., Gonadotropin-releasing hormone receptors: Structure and signal transduction pathways (1994) Endoc. Rev., 15, pp. 462-499
  • Sylvester, P.W., Sarkar, D.K., Briski, K.P., Meites, J., Relation of gonadal hormones to differential LH response to naloxone in prepubertal male and female rats (1985) Neuroendocrinology, 40, pp. 165-170
  • Tomic, M., Cesnjaj, M., Catt, K.J., Stojilkovic, S.S., Developmental and physiological aspects of Ca2+ signaling in agonist-stimulated pituitary gonadotrophs (1994) Endocrinology, 135, pp. 1762-1771
  • Van Vugt, D.A., Sylvester, P.W., Aylsworth, C.F., Meites, J., Counteraction of gonadal steroid inhibition of luteinising hormone release by naloxone (1982) Neuroendocrinology, 33, pp. 261-264
  • Vreeburg, J.T.M., Van Der Vaart, P.D.M., Van Der Schoot, P., Prevention of central defeminization but not masculinization in male rats by inhibition neonatally of oestrogen biosynthesis (1977) J. Endocrinol., 74, pp. 375-382
  • Wray, S., Gainer, H., Effect of neonatal gonadectomy on postnatal development in rat LHRH cell subtypes in male and female rats (1987) Neuroendocrinology, 45, pp. 413-419
  • Wuttke, W., Honma, K., Lamberts, S.W.J., Hohn, K.G., The role of monoamines in female puberty (1980) Fed. Proc., 39, pp. 2378-2383
  • Yamamoto, M., Diebel, N.D., Bogdanove, E.M., Analysis of initial and delayed effects of orchidectomy and ovariectomy on pituitary and serum LH levels in adult and immature rats (1970) Endocrinology, 86, pp. 1102-1111

Citas:

---------- APA ----------
Becú-Villalobos, D., Iglesias, A.G., Díaz-Torga, G., Hockl, P. & Libertun, C. (1997) . Brain sexual differentiation and gonadotropins secretion in the rat. Cellular and Molecular Neurobiology, 17(6), 699-715.
http://dx.doi.org/10.1023/A:1022542221535
---------- CHICAGO ----------
Becú-Villalobos, D., Iglesias, A.G., Díaz-Torga, G., Hockl, P., Libertun, C. "Brain sexual differentiation and gonadotropins secretion in the rat" . Cellular and Molecular Neurobiology 17, no. 6 (1997) : 699-715.
http://dx.doi.org/10.1023/A:1022542221535
---------- MLA ----------
Becú-Villalobos, D., Iglesias, A.G., Díaz-Torga, G., Hockl, P., Libertun, C. "Brain sexual differentiation and gonadotropins secretion in the rat" . Cellular and Molecular Neurobiology, vol. 17, no. 6, 1997, pp. 699-715.
http://dx.doi.org/10.1023/A:1022542221535
---------- VANCOUVER ----------
Becú-Villalobos, D., Iglesias, A.G., Díaz-Torga, G., Hockl, P., Libertun, C. Brain sexual differentiation and gonadotropins secretion in the rat. Cell. Mol. Neurobiol. 1997;17(6):699-715.
http://dx.doi.org/10.1023/A:1022542221535