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Abstract:

1. After reaching its final destination the GnRH neuronal network develops under the influence of both excitatory and inhibitory inputs. 2. In the first 2 weeks of life, the immaturity of the GnRH neuronal system is reflected in sporadic unsynchronized bursts of the decapeptide, which determine the pattern of serum gonadotropin levels observed in female rats: high FSH levels and transient bursts of LH. The main inhibitory neuronal systems that operate in this period are the opioid and dopaminergic systems. A decrease in their inhibitory effectiveness may not be sufficient correctly to activate and synchronize the GnRH neuronal system. 3. There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. 4. The morphological changes of GnRH neurons which take place during the third and fourth weeks of life, and which are probably related to increasing estradiol levels, reflects the increasing complexity of the GnRH neuronal network, which establishes synaptic contacts to enable the expression of pulsatility and of the positive feedback of estradiol, both necessary components for the occurrence of puberty. © 1995 Plenum Publishing Corporation.

Registro:

Documento: Artículo
Título:Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat
Autor:Becú-Villalobos, D.; Libertun, C.
Filiación:Instituto de Biología y Medicina Experimental, CONICET, Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:gonadotropin-releasing hormone; growth factors; neurotransmitters; ontogeny; rat; gonadorelin; animal experiment; dopaminergic system; female; gonadorelin release; hormonal regulation; nerve cell network; neurotransmission; nonhuman; priority journal; puberty; rat; review; Aging; Animal; Catecholamines; Dopamine; Endorphins; Excitatory Amino Acids; Female; Follicle Stimulating Hormone; Gonadorelin; Homeostasis; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Neurons; Neuropeptides; Norepinephrine; Rats; Serotonin; Support, Non-U.S. Gov't; Synapses; Animalia
Año:1995
Volumen:15
Número:1
Página de inicio:165
Página de fin:176
DOI: http://dx.doi.org/10.1007/BF02069564
Título revista:Cellular and Molecular Neurobiology
Título revista abreviado:Cell Mol Neurobiol
ISSN:02724340
CODEN:CMNED
CAS:Catecholamines; Dopamine, 51-61-6; Endorphins; Excitatory Amino Acids; Follicle Stimulating Hormone, 9002-68-0; Gonadorelin, 33515-09-2; Luteinizing Hormone, 9002-67-9; Neuropeptides; Norepinephrine, 51-41-2; Serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02724340_v15_n1_p165_BecuVillalobos

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Citas:

---------- APA ----------
Becú-Villalobos, D. & Libertun, C. (1995) . Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat. Cellular and Molecular Neurobiology, 15(1), 165-176.
http://dx.doi.org/10.1007/BF02069564
---------- CHICAGO ----------
Becú-Villalobos, D., Libertun, C. "Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat" . Cellular and Molecular Neurobiology 15, no. 1 (1995) : 165-176.
http://dx.doi.org/10.1007/BF02069564
---------- MLA ----------
Becú-Villalobos, D., Libertun, C. "Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat" . Cellular and Molecular Neurobiology, vol. 15, no. 1, 1995, pp. 165-176.
http://dx.doi.org/10.1007/BF02069564
---------- VANCOUVER ----------
Becú-Villalobos, D., Libertun, C. Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat. Cell Mol Neurobiol. 1995;15(1):165-176.
http://dx.doi.org/10.1007/BF02069564