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Bezrodnik, L.; Gómez Raccio, A.; Belardinelli, G.; Regairaz, L.; Díaz Ballve, D.; Seminario, G.; Moreira, I.; Riganti, C.; Cantisano, C.; Díaz, H.; Di Giovanni, D. "Comparative study of subcutaneous versus intravenous IgG replacement therapy in pediatric patients with primary immunodeficiency diseases: A multicenter study in Argentina" (2013) Journal of Clinical Immunology. 33(7):1216-1222
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Abstract:

Purpose: Several studies have shown that subcutaneous immunoglobulin (SCIG) infusions demonstrate similar efficacy to intravenous Ig (IVIG) in preventing infections in patients with primary immunodeficiency diseases (PID), and are safe and well tolerated in this population. This open, prospective/ retrospective, multicenter study was designed to compare the effectiveness, safety and tolerability of a 16 % liquid human IgG preparation (Beriglobina P), administered SC, with previous IVIG treatment in PID pediatric patients in Argentina. Methods: Fifteen subjects were enrolled in the study, and a total of 13 subjects (aged 6-18 years) completed the 36-week SCIG treatment period. All children had previously received IVIG treatment. The dose of SCIG equaled the previous IVIG dose and subjects received an average weekly dose of 139 mg/kg (range 105-181) during the SCIG period. Results: Significantly higher serum IgG trough levels were recorded on SCIG treatment at 16, 24, and 36 weeks, when compared with previous IgG trough levels on steady-state IVIG treatment. The annualized infection rate was 1.4 infections/subject/year during the IVIG administration period compared with 0.4 infections/subject/year during the SCIG period. All subjects who completed the study chose to continue administering SCIG at home after the study had ended. Conclusions: These data confirm that self-administered SCIG therapy is a well-tolerated and effective alternative to IVIG therapy for children with PID. © 2013 Springer Science+Business Media New York.

Registro:

Documento: Artículo
Título:Comparative study of subcutaneous versus intravenous IgG replacement therapy in pediatric patients with primary immunodeficiency diseases: A multicenter study in Argentina
Autor:Bezrodnik, L.; Gómez Raccio, A.; Belardinelli, G.; Regairaz, L.; Díaz Ballve, D.; Seminario, G.; Moreira, I.; Riganti, C.; Cantisano, C.; Díaz, H.; Di Giovanni, D.
Filiación:Inmunología, Hospital de Niños Dr. Ricardo Gutiérrez Pedro Goyena, 3944, Olivos, Provincia de Buenos Aires 1636, Argentina
Inmunología, Hospital de Niños Sor María Ludovica, La Plata, Argentina
Inmunología, Hospital de Niños Pedro Elizalde, Buenos Aires, Argentina
Inmunología, Hospital de Niños Dr. Ricardo Gutiérrez, Gallo 1330, Ciudad de Buenos Aires, CP 1428, Argentina
Palabras clave:Argentina; Beriglobina P; children; immunoglobulin therapy; intravenous; primary immunodeficiency; subcutaneous; human immunoglobulin; adolescent; adult; Argentina; article; child; clinical article; clinical trial; comparative study; controlled study; drug efficacy; drug safety; drug self administration; drug tolerability; female; fever; headache; human; immune deficiency; immunoglobulin blood level; infection rate; infusion related reaction; injection site erythema; injection site pain; injection site pruritus; injection site swelling; male; multicenter study; nausea; open study; preschool child; priority journal; prospective study; retrospective study; school child; severe combined immunodeficiency; X linked agammaglobulinemia; Adolescent; Argentina; Child; Feasibility Studies; Female; Humans; Immunoglobulin G; Immunoglobulins, Intravenous; Immunologic Deficiency Syndromes; Immunotherapy; Infection; Injections, Subcutaneous; Male; Prospective Studies
Año:2013
Volumen:33
Número:7
Página de inicio:1216
Página de fin:1222
DOI: http://dx.doi.org/10.1007/s10875-013-9916-z
Título revista:Journal of Clinical Immunology
Título revista abreviado:J. Clin. Immunol.
ISSN:02719142
CODEN:JCIMD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02719142_v33_n7_p1216_Bezrodnik

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Citas:

---------- APA ----------
Bezrodnik, L., Gómez Raccio, A., Belardinelli, G., Regairaz, L., Díaz Ballve, D., Seminario, G., Moreira, I.,..., Di Giovanni, D. (2013) . Comparative study of subcutaneous versus intravenous IgG replacement therapy in pediatric patients with primary immunodeficiency diseases: A multicenter study in Argentina. Journal of Clinical Immunology, 33(7), 1216-1222.
http://dx.doi.org/10.1007/s10875-013-9916-z
---------- CHICAGO ----------
Bezrodnik, L., Gómez Raccio, A., Belardinelli, G., Regairaz, L., Díaz Ballve, D., Seminario, G., et al. "Comparative study of subcutaneous versus intravenous IgG replacement therapy in pediatric patients with primary immunodeficiency diseases: A multicenter study in Argentina" . Journal of Clinical Immunology 33, no. 7 (2013) : 1216-1222.
http://dx.doi.org/10.1007/s10875-013-9916-z
---------- MLA ----------
Bezrodnik, L., Gómez Raccio, A., Belardinelli, G., Regairaz, L., Díaz Ballve, D., Seminario, G., et al. "Comparative study of subcutaneous versus intravenous IgG replacement therapy in pediatric patients with primary immunodeficiency diseases: A multicenter study in Argentina" . Journal of Clinical Immunology, vol. 33, no. 7, 2013, pp. 1216-1222.
http://dx.doi.org/10.1007/s10875-013-9916-z
---------- VANCOUVER ----------
Bezrodnik, L., Gómez Raccio, A., Belardinelli, G., Regairaz, L., Díaz Ballve, D., Seminario, G., et al. Comparative study of subcutaneous versus intravenous IgG replacement therapy in pediatric patients with primary immunodeficiency diseases: A multicenter study in Argentina. J. Clin. Immunol. 2013;33(7):1216-1222.
http://dx.doi.org/10.1007/s10875-013-9916-z