Abstract:
Interferon-gamma (IFN-γ) production by peripheral blood mononuclear cells (PBMC) in 14 patients with anorexia nervosa (AN) was significantly lower than in 14 age-matched healthy controls. Follow-up samples in four patients displayed low levels, except in two when they recovered the IFN-γ production as the hormonal cycles were restored. A large interindividual variation for the lymphocyte proliferative response was observed in 30 AN patients. DNA synthesis of PBMC was normal in 8 patients (27%), significantly increased in 6 (20%) (P<0.001), and significantly decreased in 16 (53%) (P<0.001). IFN-γ inhibition was reversed by culturing a control lymphocyte population with monocytes from patients with AN. This was not observed in cultures of control monocytes and AN lymphocytes. IL-2 receptor (TAC subunit) was assessed and no difference was found in the number of TAC-positive cells between patients and controls. These results point out impaired production of the immunomodulator cytokine IFN-γ as a major functional defect of AN peripheral lymphocytes. © 1993 Plenum Publishing Corporation.
Registro:
Documento: |
Artículo
|
Título: | Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients |
Autor: | Polack, E.; Nahmod, V.E.; Emeric-Sauval, E.; Bello, M.; Costas, M.; Finkielman, S.; Arzt, E. |
Filiación: | Departamento de Sustancias Vasoactivas, Instituto de Investigaciones Medicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina Servicio de Endocrinologia, Hospital Durand, Buenos Aires, Argentina Servicio de Psiquiatria, Hospital Udaondo, Buenos Aires, Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas (Conicet-Argentina), Buenos Aires, Argentina Departamento de Biologia, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
|
Palabras clave: | Anorexia nervosa; DNA synthesis; interferon-gamma synthesis; gamma interferon; interleukin 2 receptor; adolescent; adult; anorexia nervosa; article; clinical article; controlled study; dna synthesis; female; human; human cell; lymphocyte proliferation; monocyte; priority journal; Adolescent; Adult; Anorexia Nervosa; Cells, Cultured; DNA; DNA Replication; Female; Follow-Up Studies; Human; Interferon Type II; Lymphocyte Activation; Lymphocytes; Monocytes; Receptors, Interleukin-2; Support, Non-U.S. Gov't |
Año: | 1993
|
Volumen: | 13
|
Número: | 6
|
Página de inicio: | 445
|
Página de fin: | 451
|
DOI: |
http://dx.doi.org/10.1007/BF00920020 |
Título revista: | Journal of Clinical Immunology
|
Título revista abreviado: | J Clin Immunol
|
ISSN: | 02719142
|
CODEN: | JCIMD
|
CAS: | DNA, 9007-49-2; Interferon Type II, 82115-62-6; Receptors, Interleukin-2
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02719142_v13_n6_p445_Polack |
Referencias:
- Russel, G., The present status of anorexia nervosa (1977) Psychol Med, 7, pp. 363-367
- Spitzer, R.L., Endicott, J., Robins, E., Research diagnostic criteria: Rationale and reliability (1978) Arch Gen Psychiat, 35, pp. 773-782
- Garfinkel, P.E., Brown, G.M., Stancer, H.C., Moldofsky, H., Hypothalamic-pituitary function in anorexia nervosa (1975) Arch Gen Psychiat, 32, pp. 739-744
- Gold, P., Gwirtsman, H., Avgerinos, P., Nieman, L., Gallucci, W., Kaye, W., Jimerson, D., Chrousos, G., Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa (1986) N Engl J Med, 314, pp. 335-342
- Vigersky, R.A., Loriaux, D., Andersen, A.E., Lipsett, Anorexia nervosa: Behavioural and hypothalamic aspects (1976) Clin Endocrinol Metab, 5, pp. 517-535
- Crisp, A.H., Anorexia nervosa-feeding disorder, nervous malnutrition or weight fobia? (1970) World Rev Nutr Diet, 12, pp. 452-504
- Brambilla, F., Anorexia nervosa and depression: A common biochemical pathogenesis? (1986) Funct Neurol, 1 i, pp. 191-202
- Katz, J.L., Anorexia nervosa and depression: Another view (letter) (1986) Am J Psychiat, 143, pp. 270-271
- Calabrese, J., Kling, M., Gold, P., Alterations in immuno competence during stress, bereavement and depression: Focus on neuroendocrine regulation (1987) Am J Psychiat, 144, pp. 1123-1134
- Dantzer, R., Kelley, K., Stress and immunity: An integrated view of relationships between the brain and the Immune System (1989) Life Sci, 44, pp. 1995-2008
- McMurray, D.N., Watson, R.R., Reyes, M.A., Effect of renutrition on humoral and cell-mediated immunity in severely malnourished children (1981) Am J Clin Nutr, 34, pp. 2117-2121
- Stein, M., Keller, S., Schleifer, S., Stress and immunomodulation: The role of depression and neuroendocrine function (1985) J Immunol, 135, pp. 827s-833s
- Artrong-Esther, C.A., Lacey, J.H., Bryant, T.N., Crisp, A.H., An investigation of the immune response of patients suffering from anorexia nervosa (1978) Post-Grad Med J, 54, pp. 395-399
- Cason, J., Ainley, C.C., Wolstencroft, R.A., Norton, K.R.W., Thompsom, R.P.H., Cell-mediated immunity in anorexia nervosa (1986) Clin Exp Immunol, 64, pp. 370-375
- Golla, A.G., Larson, L.A., Anderson, C.F., Lucas, A.R., Wilson, W.R., Tomasi, T.B., An immunological assessment of patients with anorexia nervosa (1981) Am J Clin Nutr, 34, pp. 2756-2762
- Dowd P, Kelleher J, Walker B, Guillou P: Nutritional and immunological assessment of patients with anorexia nervosa. Proc Nutr Soc 43:90A, 1984; Vaisman, N., Hahn, T., Dayan, Y., Schattner, A., The effect of different nutritional states on cell-mediated cytotoxicity (1990) Immunol Lett, 24, pp. 37-41
- Schattner, A., Steinbock, M., Tepper, R., Schonfeld, A., Vaisman, N., Hahn, T., Tumor necrosis factor production and cell-mediated immunity in anorexia nervosa (1990) Clin Exp Immunol, 79, pp. 62-66
- (1987) Diagnostic and Statistical Manual of Mental Disorders, , American Psychiatric Association, 3rd ed., American Psychiatric Association, Washington, DC
- Böyun, W., Separation of lymphocytes from peripheral blood and bone marrow (1968) Scand J Clin Invest, 21, pp. 77-89
- Arzt, E., Fernandez Castelo, S., Finocchiaro, L., Criscuolo, M., Díaz, A., Finkielman, S., Nahmod, V.E., Immunomodulation by indoleamines: serotonin and melatonin action on DNA and interferon-γ synthesis by human peripheral blood mononuclear cells (1988) J Clin Immunol, 8, pp. 513-520
- Bertran, G., Arzt, E., Resnik, E., Mosca, C., Nahmod, V.E., Inhibition of interferon gamma production by peripheral blood mononuclear leukocytes of patients with sarcoidosis (1992) Chest, 101, pp. 996-999
- Rinehart, J., Zanjani, E., Nomdedeu, B., Gormus, B., Kaplan, M., Cell-cell interaction in erythropoiesis: Role of human monocytes (1978) J Clin Invest, 62, pp. 979-986
- Sterin Pryne, A., Arzt, E., Fernandez Castelo, S., Finkielman, S., Nahmod, V.E., The inhibitory effect of the muscarinic agonist pilocarpine on lymphocyte activation involves the IL-2 pathway and the increase in suppressor cell function (1992) Int J Neurosci, 62, pp. 277-285
- Finocchiaro, L., Arzt, E., Fernández Castelo, S., Criscuolo, M., Finkielman, S., Nahmod, V., Serotonin and melatonin synthesis in peripheral blood mononuclear cells: Stimulation by interferon-gamma as part of an immunomodulation pathway (1988) J Interferon Res, 8, pp. 705-709
- Gonzalez, M.C., Riedel, M., Rettori, V., Yu, W.H., McCann, S.M., Effect of recombinant human gamma-interferon on the release of anterior pituitary hormones (1990) Prog Neuroendocrinol, 3, pp. 49-54
- Holsboer, F., Stalla, G.K., von Bardeleben, V., Hamman, K., Müller, H., Müller, O.A., Acute adrenocortical stimulation by recombinant gamma interferon in human controls (1988) Life Sci, 42, pp. 1-5
- Spöth-Schwalbe, E., Porzsolt, F., Digel, W., Born, J., Klors, B., Fehm, H.L., Elevated plasma cortisol levels during interferon-gamma treatment (1989) Immunopharmacology, 17, pp. 141-145
- Vanbelecom, H., Carmelief, P., Heremans, H., van Damme, J., Dijkmans, R., Billiau, A., Denef, C., Interferon-gamma inhibits stimulated adrenocorticotrophin, prolactin and growth hormone secretion in normal rat anterior pituitary cell cultures (1990) Endocrinology, 126, pp. 2919-2926
- Chiappelli, F., Gwirtsman, H.E., Lowy, M., Gormley, G., Nguyen, L.D., Popow, J., Esmail, I., Strober, M., Pituitary-adrenal-immune system in normal subjects and in patients with anorexia nervosa: The number of circulating helper T lymphocytes (CD4) expressing the homing receptor Leu8 is regulated in part by pituitary-adrenal products (1991) Psychoneuroendocrinology, 16, pp. 423-432
- Kenedy, S.H., Brown, G.M., Garfinkel, P.E., McVey, G., Pacienti, V., Sulphatoximelatonin: An index of depression in anorexia nervosa and bulimia nervosa (1990) Psychiatry Research, 32, pp. 221-227
- Van Binsbergen, C.J.M., Coelingh Bennik, H.J.T., Odink, J., Haspels, A.A., Koppeschaar, H.P.F., A comparative and longitudinal study on endocrine changes related to ovarian function in patients with anorexia nervosa (1990) J Clin Endocrinol Metab, 71, pp. 705-711
Citas:
---------- APA ----------
Polack, E., Nahmod, V.E., Emeric-Sauval, E., Bello, M., Costas, M., Finkielman, S. & Arzt, E.
(1993)
. Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients. Journal of Clinical Immunology, 13(6), 445-451.
http://dx.doi.org/10.1007/BF00920020---------- CHICAGO ----------
Polack, E., Nahmod, V.E., Emeric-Sauval, E., Bello, M., Costas, M., Finkielman, S., et al.
"Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients"
. Journal of Clinical Immunology 13, no. 6
(1993) : 445-451.
http://dx.doi.org/10.1007/BF00920020---------- MLA ----------
Polack, E., Nahmod, V.E., Emeric-Sauval, E., Bello, M., Costas, M., Finkielman, S., et al.
"Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients"
. Journal of Clinical Immunology, vol. 13, no. 6, 1993, pp. 445-451.
http://dx.doi.org/10.1007/BF00920020---------- VANCOUVER ----------
Polack, E., Nahmod, V.E., Emeric-Sauval, E., Bello, M., Costas, M., Finkielman, S., et al. Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients. J Clin Immunol. 1993;13(6):445-451.
http://dx.doi.org/10.1007/BF00920020