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Abstract:

Balb/c mice fed a diet containing 20% fish oil developed herpes stromal keratitis earlier and with more severe lesions than control group. Peritoneal macrophages oxidative metabolism and intrinsic antiviral activity are not modified by diet manipulation but nitric oxide production was significantly impaired. On the contrary, splenic lymphocytes proliferation stimulated "ex vivo" by heat inactivated HSV-1 is significantly increased as well as delayed type hypersensitivity. So, taking into account that herpes stromal keratitis is mediated by T cells, the effect of diet over these cells could be responsible for the observed exacerbation of the disease. © 2001 Elsevier Science Inc.

Registro:

Documento: Artículo
Título:Effect of dietary fish oil on mouse ocular Herpes Simplex type I infection
Autor:Courrèges, M.Cecilia; Benencia, F.; Monserrat, A.J.
Filiación:Centro de Patología Experimental, Facultad de Medicina, Universidad de Buenos Aires, J. E. Uriburu 950, 5to, Piso (1114) Buenos Aires, Argentina
Dpto. Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Tel.: +54-11-4508-3602
Palabras clave:Fish oil; Herpes Simplex type 1; Immune response; Lymphocytes; Macrophages; Ocular keratitis; corn oil; fish oil; animal experiment; animal model; article; controlled study; delayed hypersensitivity; diet; disease association; disease course; disease severity; herpes simplex keratitis; immune response; lymphocyte proliferation; mouse; nonhuman; priority journal; T lymphocyte; Herpes; Human herpesvirus 1
Año:2001
Volumen:21
Número:1-2
Página de inicio:229
Página de fin:241
DOI: http://dx.doi.org/10.1016/S0271-5317(00)00260-8
Título revista:Nutrition Research
Título revista abreviado:Nutr. Res.
ISSN:02715317
CODEN:NTRSD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02715317_v21_n1-2_p229_Courreges

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Citas:

---------- APA ----------
Courrèges, M.Cecilia, Benencia, F. & Monserrat, A.J. (2001) . Effect of dietary fish oil on mouse ocular Herpes Simplex type I infection. Nutrition Research, 21(1-2), 229-241.
http://dx.doi.org/10.1016/S0271-5317(00)00260-8
---------- CHICAGO ----------
Courrèges, M.Cecilia, Benencia, F., Monserrat, A.J.. "Effect of dietary fish oil on mouse ocular Herpes Simplex type I infection" . Nutrition Research 21, no. 1-2 (2001) : 229-241.
http://dx.doi.org/10.1016/S0271-5317(00)00260-8
---------- MLA ----------
Courrèges, M.Cecilia, Benencia, F., Monserrat, A.J.. "Effect of dietary fish oil on mouse ocular Herpes Simplex type I infection" . Nutrition Research, vol. 21, no. 1-2, 2001, pp. 229-241.
http://dx.doi.org/10.1016/S0271-5317(00)00260-8
---------- VANCOUVER ----------
Courrèges, M.Cecilia, Benencia, F., Monserrat, A.J.. Effect of dietary fish oil on mouse ocular Herpes Simplex type I infection. Nutr. Res. 2001;21(1-2):229-241.
http://dx.doi.org/10.1016/S0271-5317(00)00260-8