Artículo

Proietti, C.J.; Rosemblit, C.; Beguelin, W.; Rivas, M.A.; Flaqué, M.C.D.; Charreau, E.H.; Schillaci, R.; Elizalde, P.V. "Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth" (2009) Molecular and Cellular Biology. 29(5):1249-1265
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Abstract:

Cross talk between the steroid hormone receptors for estrogen and progesterone (PR) and the ErbB family of receptor tyrosine kinases appears to be a hallmark of breast cancer growth, but its underlying mechanism remains poorly explored. Here we have highlighted signal transducer and activator of transcription 3 (Stat3) as a key protein activated by heregulin (HRG), a ligand of the ErbB receptors, through co-opted, ligand-independent PR function as a signaling molecule. Stat3 activation was an absolute requirement in HRG-induced mammary tumor growth, and targeting Stat3 effectively inhibited growth of breast cancer cells with activated HRG/ErbB-2 and PR. Our findings unravel a novel potential therapeutic intervention in PR- and ErbB-2-positive breast tumors, involving the specific blockage of PR signaling activity. Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Registro:

Documento: Artículo
Título:Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth
Autor:Proietti, C.J.; Rosemblit, C.; Beguelin, W.; Rivas, M.A.; Flaqué, M.C.D.; Charreau, E.H.; Schillaci, R.; Elizalde, P.V.
Filiación:Instituto de Biología Y Medicina Experimental, CONICET, Obligado 2490, Buenos Aires 1428, Argentina
Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología Y Medicina Experimental (IBYME), Obligado 2490, Buenos Aires 1428, Argentina
Palabras clave:epidermal growth factor receptor 2; estrogen receptor; neu differentiation factor; progesterone receptor; STAT3 protein; epidermal growth factor receptor 2; neu differentiation factor; progesterone receptor; STAT3 protein; animal cell; animal cell culture; animal experiment; animal model; article; Bagg albino mouse; breast cancer; cancer growth; enzyme activity; female; immunoprecipitation; mouse; nonhuman; priority journal; signal transduction; Western blotting; animal; cell proliferation; experimental neoplasm; metabolism; pathology; Animals; Cell Proliferation; Female; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Neuregulin-1; Receptor, erbB-2; Receptors, Progesterone; Signal Transduction; STAT3 Transcription Factor
Año:2009
Volumen:29
Número:5
Página de inicio:1249
Página de fin:1265
DOI: http://dx.doi.org/10.1128/MCB.00853-08
Título revista:Molecular and Cellular Biology
Título revista abreviado:Mol. Cell. Biol.
ISSN:02707306
CODEN:MCEBD
CAS:epidermal growth factor receptor 2, 137632-09-8; Neuregulin-1; Receptor, erbB-2, 2.7.1.112; Receptors, Progesterone; STAT3 Transcription Factor; Receptor, erbB-2, EC 2.7.1.112
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02707306_v29_n5_p1249_Proietti

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Citas:

---------- APA ----------
Proietti, C.J., Rosemblit, C., Beguelin, W., Rivas, M.A., Flaqué, M.C.D., Charreau, E.H., Schillaci, R.,..., Elizalde, P.V. (2009) . Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth. Molecular and Cellular Biology, 29(5), 1249-1265.
http://dx.doi.org/10.1128/MCB.00853-08
---------- CHICAGO ----------
Proietti, C.J., Rosemblit, C., Beguelin, W., Rivas, M.A., Flaqué, M.C.D., Charreau, E.H., et al. "Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth" . Molecular and Cellular Biology 29, no. 5 (2009) : 1249-1265.
http://dx.doi.org/10.1128/MCB.00853-08
---------- MLA ----------
Proietti, C.J., Rosemblit, C., Beguelin, W., Rivas, M.A., Flaqué, M.C.D., Charreau, E.H., et al. "Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth" . Molecular and Cellular Biology, vol. 29, no. 5, 2009, pp. 1249-1265.
http://dx.doi.org/10.1128/MCB.00853-08
---------- VANCOUVER ----------
Proietti, C.J., Rosemblit, C., Beguelin, W., Rivas, M.A., Flaqué, M.C.D., Charreau, E.H., et al. Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth. Mol. Cell. Biol. 2009;29(5):1249-1265.
http://dx.doi.org/10.1128/MCB.00853-08