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Federman, N.; de la Fuente, V.; Zalcman, G.; Corbi, N.; Onori, A.; Passananti, C.; Romano, A. "Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory" (2013) Journal of Neuroscience. 33(17):7603-7614
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Abstract:

Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated by histone acetylases and deacetylases. It is not yet clear whether memory consolidation always recruits histone acetylation or it is only engaged in more persistent memories. To address this question, we used different strength of training for novel object recognition task in mice. Only strong training induced a long-lasting memory and an increase in hippocampal histone H3 acetylation. Histone acetylase inhibition in the hippocampus during consolidation impaired memory persistence, whereas histone deacetylase inhibition caused weak memory to persist. Nuclear factor κB (NF-κB) transcription factor inhibition impaired memory persistence and, concomitantly, reduced the general level of H3 acetylation. Accordingly, we found an important increase in H3 acetylation at a specific NF-κB-regulated promoter region of the Camk2d gene, which was reversed by NF-kB inhibition. These results show for the first time that histone acetylation is a specific molecular signature of enduring memories. ©2013 the authors.

Registro:

Documento: Artículo
Título:Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory
Autor:Federman, N.; de la Fuente, V.; Zalcman, G.; Corbi, N.; Onori, A.; Passananti, C.; Romano, A.
Filiación:Departamento de Fisiologia, Biologia Molecular y Celular, Universidad de Buenos Aires, Instituto de Fisiologia, Biologia Molecular y Neurociencias, Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Universitaria, Buenos Aires, Argentina
Consiglio Nazionale delle Ricerche, Institute of Molecular Biology and Pathology, Department of Molecular Medicine, La Sapienza University, Rome, 00161, Italy
Palabras clave:calcium calmodulin dependent protein kinase II; histone H3; immunoglobulin enhancer binding protein; animal experiment; article; behavior; chromatin immunoprecipitation; controlled study; gene expression; histone acetylation; male; memory; mouse; nonhuman; pattern recognition; priority journal; protein expression; real time polymerase chain reaction; task performance; training; Western blotting; Acetylation; Animals; Histone Acetyltransferases; Histones; Learning; Male; Memory; Mice; Mice, Inbred C57BL; NF-kappa B; Recognition (Psychology)
Año:2013
Volumen:33
Número:17
Página de inicio:7603
Página de fin:7614
DOI: http://dx.doi.org/10.1523/JNEUROSCI.4181-12.2013
Título revista:Journal of Neuroscience
Título revista abreviado:J. Neurosci.
ISSN:02706474
CODEN:JNRSD
CAS:calcium calmodulin dependent protein kinase II, 141467-21-2; Histone Acetyltransferases, 2.3.1.48; Histones; NF-kappa B
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v33_n17_p7603_Federman

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Citas:

---------- APA ----------
Federman, N., de la Fuente, V., Zalcman, G., Corbi, N., Onori, A., Passananti, C. & Romano, A. (2013) . Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory. Journal of Neuroscience, 33(17), 7603-7614.
http://dx.doi.org/10.1523/JNEUROSCI.4181-12.2013
---------- CHICAGO ----------
Federman, N., de la Fuente, V., Zalcman, G., Corbi, N., Onori, A., Passananti, C., et al. "Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory" . Journal of Neuroscience 33, no. 17 (2013) : 7603-7614.
http://dx.doi.org/10.1523/JNEUROSCI.4181-12.2013
---------- MLA ----------
Federman, N., de la Fuente, V., Zalcman, G., Corbi, N., Onori, A., Passananti, C., et al. "Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory" . Journal of Neuroscience, vol. 33, no. 17, 2013, pp. 7603-7614.
http://dx.doi.org/10.1523/JNEUROSCI.4181-12.2013
---------- VANCOUVER ----------
Federman, N., de la Fuente, V., Zalcman, G., Corbi, N., Onori, A., Passananti, C., et al. Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory. J. Neurosci. 2013;33(17):7603-7614.
http://dx.doi.org/10.1523/JNEUROSCI.4181-12.2013