Artículo

Fernandez, P.C.; Locatelli, F.F.; Person-Rennell, N.; Deleo, G.; Smith, B.H. "Associative conditioning tunes transient dynamics of early olfactory processing" (2009) Journal of Neuroscience. 29(33):10191-10202
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Abstract:

Odors evoke complex spatiotemporal responses in the insect antennal lobe (AL) and mammalian olfactory bulb. However, the behavioral relevance of spatiotemporal coding remains unclear. In the present work we combined behavioral analyses with calcium imaging of odor induced activity in the honeybee AL to evaluate the relevance of this temporal dimension in the olfactory code. We used a new way for evaluation of odor similarity of binary mixtures in behavioral studies, which involved testing whether a match of odor-sampling time is necessary between training and testing conditions for odor recognition during associative learning. Using graded changes in the similarity of the mixture ratios, we found high correlations between the behavioral generalization across those mixtures and a gradient of activation in AL output. Furthermore, short odor stimuli of 500 ms or less affected how well odors were matched with a memory template, and this time corresponded to a shift from a sampling-time-dependent to a sampling-time-independent memory. Accordingly, 375 ms corresponded to the time required for spatiotemporal AL activity patterns to reach maximal separation according to imaging studies. Finally, we compared spatiotemporal representations of binary mixtures in trained and untrained animals. AL activity was modified by conditioning to improve separation of odor representations. These data suggest that one role of reinforcement is to "tune" the AL such that relevant odors become more discriminable. Copyright © 2009 Society for Neuroscience.

Registro:

Documento: Artículo
Título:Associative conditioning tunes transient dynamics of early olfactory processing
Autor:Fernandez, P.C.; Locatelli, F.F.; Person-Rennell, N.; Deleo, G.; Smith, B.H.
Filiación:Arizona State University, School of Life Sciences, Tempe, AZ 85287-4501, United States
Instituto Nacional de Tecnología Agropecuaria, Universidad de Buenos Aires, Departamento de Biologia Aplicada Y Alimentos, Avenida San Martin 4453, Ciudad Autónoma de Buenos Aires, Argentina
Departamento Fisiología, Biología Molecular Y Celular, Universidad de Buenos Aires, Instituto de Fisiología, C1428EHA Ciudad Autónoma de Buenos Aires, Argentina
Palabras clave:2 octanol; hexanol; animal experiment; article; behavioral science; controlled study; honeybee; nonhuman; odor; olfactory discrimination; olfactory memory; priority journal; reinforcement; smelling; state dependent learning; stimulus response; temporal lobe; Animals; Association Learning; Bees; Conditioning (Psychology); Odors; Olfactory Pathways; Reaction Time; Smell; Time Factors
Año:2009
Volumen:29
Número:33
Página de inicio:10191
Página de fin:10202
DOI: http://dx.doi.org/10.1523/JNEUROSCI.1874-09.2009
Título revista:Journal of Neuroscience
Título revista abreviado:J. Neurosci.
ISSN:02706474
CODEN:JNRSD
CAS:2 octanol, 123-96-6; hexanol, 111-27-3, 25917-35-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v29_n33_p10191_Fernandez

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Citas:

---------- APA ----------
Fernandez, P.C., Locatelli, F.F., Person-Rennell, N., Deleo, G. & Smith, B.H. (2009) . Associative conditioning tunes transient dynamics of early olfactory processing. Journal of Neuroscience, 29(33), 10191-10202.
http://dx.doi.org/10.1523/JNEUROSCI.1874-09.2009
---------- CHICAGO ----------
Fernandez, P.C., Locatelli, F.F., Person-Rennell, N., Deleo, G., Smith, B.H. "Associative conditioning tunes transient dynamics of early olfactory processing" . Journal of Neuroscience 29, no. 33 (2009) : 10191-10202.
http://dx.doi.org/10.1523/JNEUROSCI.1874-09.2009
---------- MLA ----------
Fernandez, P.C., Locatelli, F.F., Person-Rennell, N., Deleo, G., Smith, B.H. "Associative conditioning tunes transient dynamics of early olfactory processing" . Journal of Neuroscience, vol. 29, no. 33, 2009, pp. 10191-10202.
http://dx.doi.org/10.1523/JNEUROSCI.1874-09.2009
---------- VANCOUVER ----------
Fernandez, P.C., Locatelli, F.F., Person-Rennell, N., Deleo, G., Smith, B.H. Associative conditioning tunes transient dynamics of early olfactory processing. J. Neurosci. 2009;29(33):10191-10202.
http://dx.doi.org/10.1523/JNEUROSCI.1874-09.2009