Artículo

Guo, C.; Qiu, H.-Y.; Shi, M.; Huang, Y.; Johnson, R.L.; Rubinstein, M.; Chen, S.-D.; Ding, Y.-Q. "Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons" (2008) Journal of Neuroscience. 28(52):14097-14106
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Abstract:

The LIM homeodomain transcription factor Lmx1b has been suggested to be required for the differentiation of midbrain dopaminergic (mDA) neurons. However, whether the loss of mDA neurons in Lmx1b-/- mice is due to its intrinsic role in the mDA lineage or to a consequence of the malformations caused by the earlier mid/hindbrain patterning defects remains to be clarified. We report here that Lmx1b expression in mDA neurons is dispensable for their differentiation and maintenance, and the loss of mDA neurons in Lmx1b -/- mice is due to the disruption of inductive activity of the isthmic organizer (IsO) in the absence of Lmx1b at the mid/hindbrain boundary (MHB). We found that mDA neurons revealed by tyrosine hydroxylase (TH), Pitx3, Nurr1, and dopamine transporter were indistinguishable from wild-type controls during embryonic development as well as in adulthood in TH-Cre;Lmx1b flox/- and DatCre/+;Lmx1bflox/- mice, in which Lmx1b was selectively deleted in differentiating mDA neurons. In addition, mDA neurons were recovered in Lmx1b-/- mice, when IsO activity was restored by Wnt1-Lmx1b transgene at MHB. The restored IsO activity was evidenced by apparently normal tectum and cerebellum and recurrence of expression of Fgf8 and Wnt1 at MHB in Wnt1Lmx1b;Lmx1b-/-. Furthermore, when Lmx1b was deleted in the whole brain after the formation of IsO by Nestin-Cre, mDA neurons were normal, whereas serotonergic neurons displayed defective development phenocopying what observed in Lmx1b-/- mice. Thus, our results indicate that the inductive activity of IsO is essential, but Lmx1b expression in mDA neurons is dispensable for their differentiation and maintenance. Copyright © 2008 Society for Neuroscience.

Registro:

Documento: Artículo
Título:Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons
Autor:Guo, C.; Qiu, H.-Y.; Shi, M.; Huang, Y.; Johnson, R.L.; Rubinstein, M.; Chen, S.-D.; Ding, Y.-Q.
Filiación:Institute of Neuroscience, Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai 200031, China
Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Department of Biochemistry and Molecular Biology, University of Texas, Maryland Anderson Cancer Center, Houston, TX 77030, United States
Instituto de Investigaciones en Ingeniería Genética Y Biología Molecular, Consejo Nacional de Investigaciones Científicas Y Técnicas, Universidad de Buenos Aires, Buenos Aires 1428, Argentina
Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China
Palabras clave:Development; Isthmic organizer; Lmx1b; Midbrain dopaminergic neurons; Substantia nigra; Transcription factor; 3,4 methylenedioxyamphetamine; dopamine transporter; transcription factor; transcription factor lmx1b; tyrosine 3 monooxygenase; unclassified drug; animal cell; animal experiment; animal tissue; article; cerebellum; controlled study; dopaminergic nerve cell; embryo development; mesencephalon; mouse; nerve cell; nerve cell differentiation; nonhuman; priority journal; protein expression; serotoninergic nerve cell; tectum; Animals; Animals, Newborn; Body Patterning; Bromodeoxyuridine; Cell Differentiation; DNA-Binding Proteins; Dopamine; Dopamine Plasma Membrane Transport Proteins; Embryo, Mammalian; Female; Gene Deletion; Gene Expression Regulation, Developmental; Homeodomain Proteins; Intermediate Filament Proteins; Mesencephalon; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Pregnancy; Rhombencephalon; Stem Cells; Transcription Factors; Tyrosine 3-Monooxygenase; Wnt1 Protein
Año:2008
Volumen:28
Número:52
Página de inicio:14097
Página de fin:14106
DOI: http://dx.doi.org/10.1523/JNEUROSCI.3267-08.2008
Título revista:Journal of Neuroscience
Título revista abreviado:J. Neurosci.
ISSN:02706474
CODEN:JNRSD
CAS:3,4 methylenedioxyamphetamine, 4764-17-4; tyrosine 3 monooxygenase, 9036-22-0; Bromodeoxyuridine, 59-14-3; DNA-Binding Proteins; Dopamine, 51-61-6; Dopamine Plasma Membrane Transport Proteins; Homeodomain Proteins; Intermediate Filament Proteins; LIM homeobox transcription factor 1 beta; Nerve Tissue Proteins; Nurr1 nuclear receptor; Transcription Factors; Tyrosine 3-Monooxygenase, 1.14.16.2; Wnt1 Protein; Wnt1 protein, mouse; homeobox protein PITX3; nestin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v28_n52_p14097_Guo

Referencias:

  • Albéri, L., Sgadò, P., Simon, H.H., Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons (2004) Development, 131, pp. 3229-3236
  • Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B., Perlmann, T., Ericson, J., Identification of intrinsic determinants of midbrain dopamine Neurons (2006) Cell, 124, pp. 393-405
  • Andersson, E., Jensen, J.B., Parmar, M., Guillemot, F., Björklund, A., Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2 (2006) Development, 133, pp. 507-516
  • Ang, S.L., Transcriptional control of midbrain dopaminergic neuron development (2006) Development, 133, pp. 3499-3506
  • Asbreuk, C.H.J., Vogelaar, C.F., Hellemons, A., Smidt, M.P., Burbach, J.P., CNS Expression pattern of Lmx1b and coexpression with Ptx genes suggest functional cooperativity in the development of forebrain motor control systems (2002) Mol Cell Neurosci, 21, pp. 410-420
  • Bayer, S.A., Wills, K.V., Triarhou, L.C., Ghetti, B., Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse (1995) Exp Brain Res, 105, pp. 191-199
  • Brodski, C., Weisenhorn, D.M.V., Signore, M., Sillaber, I., Oesterheld, M., Broccoli, V., Acampora, D., Wurst, W., Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer (2003) J Neurosci, 23, pp. 4199-4207
  • Burbach, J.P., Smidt, M.P., Molecular programming of stem cells into mesodiencephalic dopaminergic neurons (2006) Trends Neurosci, 29, pp. 601-603
  • Chen, H., Lun, Y., Ovchinnikov, D., Kokubo, H., Oberg, K.C., Pepicelli, C.V., Gan, L., Johnson, R.L., Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome (1998) Nat Genet, 19, pp. 51-55
  • Cheng, L., Chen, C.L., Luo, P., Tan, M., Qiu, M., Johnson, R., Ma, Q., Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype (2003) J Neurosci, 23, pp. 9961-9967
  • Dai, J.X., Hu, Z.L., Shi, M., Guo, C., Ding, Y.Q., Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system (2008) J Comp Neurol, 509, pp. 341-355
  • Danielian, P.S., McMahon, A.P., Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development (1996) Nature, 383, pp. 332-334
  • Ding, Y.Q., Marklund, U., Yuan, W., Yin, J., Wegman, L., Ericson, J., Deneris, E., Chen, Z.F., Lmx1b is essential for the development of serotonergic neurons (2003) Nat Neurosci, 6, pp. 933-938
  • Ding, Y.Q., Yin, J., Kania, A., Zhao, Z.Q., Johnson, R.L., Chen, Z.F., Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord (2004) Development, 131, pp. 3693-3703
  • Dreyer, S.D., Zhou, G., Baldini, A., Winterpacht, A., Zabel, B., Cole, W., Johnson, R.L., Lee, B., Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome (1998) Nat Genet, 19, pp. 47-50
  • Ferri, A.L.M., Lin, W., Mavromatakis, Y.E., Wang, J.C., Sasaki, H., Whitsett, J.A., Ang, S.L., Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner (2007) Development, 134, pp. 2761-2769
  • Gelman, D.M., Noaín, D., Avale, M.E., Otero, V., Low, M.J., Rubinstein, M., Transgenic mice engineered to target Cre/loxP-mediated DNA recombination into catecholaminergic neurons (2003) Genesis, 36, pp. 196-202
  • Guo, C., Qiu, H.Y., Huang, Y., Chen, H., Yang, R.Q., Chen, S.D., Johnson, R.L., Ding, Y.Q., Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice (2007) Development, 134, pp. 317-325
  • Hynes, M., Rosenthal, A., Specification of dopaminergic and serotonergic neurons in the vertebrate CNS (1999) Curr Opin Neurobiol, 9, pp. 26-36
  • Hynes, M., Poulsen, K., Tessier-Lavigne, M., Rosenthal, A., Control of neuronal diversity by the floor plate: Contact-mediated induction of midbrain dopaminergic neurons (1995) Cell, 80, pp. 95-101
  • Hynes, M., Porter, J.A., Chiang, C., Chang, D., Tessier-Lavigne, M., Beachy, P.A., Rosenthal, A., Induction of midbrain dopaminergic neurons by Sonic hedgehog (1995) Neuron, 15, pp. 35-44
  • Isaka, F., Ishibashi, M., Taki, W., Hashimoto, N., Nakanishi, S., Kageyama, R., Ectopic expression of the bHLH gene Math1 disturbs neural development (1999) Eur J Neurosci, 11, pp. 2582-2588
  • Joyner, A.L., Liu, A., Millet, S., Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer (2000) Curr Opin Cell Biol, 12, pp. 736-741
  • Kaufman, M.H., (1998) The atlas of mouse development, , San Diego: Academic
  • Kele, J., Simplicio, N., Ferri, A.L.M., Mira, H., Guillemot, F., Arenas, E., Ang, S.L., Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons (2006) Development, 133, pp. 495-505
  • Lee, S.H., Lumelsky, N., Studer, L., Auerbach, J.M., McKay, R.D., Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells (2000) Nat Biotechnol, 18, pp. 675-679
  • Liu, A., Joyner, A.L., Early anterior/posterior patterning of the midbrain and cerebellum (2001) Annu Rev Neurosci, 24, pp. 869-896
  • Martinat, C., Bacci, J.J., Leete, T., Kim, J., Vanti, W.B., Newman, A.H., Cha, J.H., Abeliovich, A., Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype (2006) Proc Natl Acad Sci U S A, 103, pp. 2874-2879
  • Maxwell, S.L., Ho, H.Y., Kuehner, E., Zhao, S., Li, M., Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development (2005) Dev Biol, 282, pp. 467-479
  • Millonig, J.H., Millen, K.J., Hatten, M.E., The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS (2000) Nature, 403, pp. 764-769
  • Nakamura, H., Katahira, T., Matsunaga, E., Sato, T., Isthmus organizer for midbrain and hindbrain development (2005) Brain Res Rev, 49, pp. 120-126
  • Ono, Y., Nakatani, T., Sakamoto, Y., Mizuhara, E., Minaki, Y., Kumai, M., Hamaguchi, A., Imai, T., Differences in neurogenic potential in floor plate cells along an anteroposterior location: Midbrain dopaminergic neurons originate from mesencephalic floor plate cells (2007) Development, 134, pp. 3213-3225
  • Prakash, N., Wurst, W., Genetic networks controlling the development of midbrain dopaminergic neurons (2006) J Physiol, 575, pp. 403-410
  • Prakash, N., Brodski, C., Naserke, T., Puelles, E., Gogoi, R., Hall, A., Panhuysen, M., Wurst, W., A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo (2006) Development, 133, pp. 89-98
  • Puelles, E., Annino, A., Tuorto, F., Usiello, A., Acampora, D., Czerny, T., Brodski, C., Simeone, A., Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain (2004) Development, 131, pp. 2037-2048
  • Sakurada, K., Ohshima-Sakurada, M., Palmer, T.D., Gage, F.H., Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain (1999) Development, 126, pp. 4017-4026
  • Saucedo-Cardenas, O., Quintana-Hau, J.D., Le, W.D., Smidt, M.P., Cox, J.J., De Mayo, F., Burbach, J.P., Conneely, O.M., Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons (1998) Proc Natl Acad Sci U S A, 95, pp. 4013-4018
  • Simeone, A., Positioning the isthmic organizer: Where Otx2 and Gbx2 meet (2000) Trends Genet, 16, pp. 237-240
  • Simeone, A., Genetic control of dopaminergic neuron differentiation (2005) Trends Neurosci, 28, pp. 62-65. , discussion 65-66
  • Simon, H.H., Saueressig, H., Wurst, W., Goulding, M.D., O'Leary, D.D.M., Fate of midbrain dopaminergic neurons controlled by the engrailed genes (2001) J Neurosci, 21, pp. 3126-3134
  • Simon, H.H., Thuret, S., Alberi, L., Midbrain dopaminergic neurons: Control of their cell fate by the engrailed transcription factors (2004) Cell Tissue Res, 318, pp. 53-61
  • Smidt, M.P., Asbreuk, C.H.J., Cox, J.J., Chen, H., Johnson, R.L., Burbach, J.P., A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b (2000) Nat Neurosci, 3, pp. 337-341
  • Smidt, M.P., Smits, S.M., Bouwmeester, H., Hamers, F.P.T., van der Linden, A.J.A., Hellemons, A.J.C.G., Graw, J., Burbach, J.P., Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3 (2004) Development, 131, pp. 1145-1155
  • Vernay, B., Koch, M., Vaccarino, F., Briscoe, J., Simeone, A., Kageyama, R., Ang, S.L., Otx2 regulates subtype specification and neurogenesis in the midbrain (2005) J Neurosci, 25, pp. 4856-4867
  • Wallén, A., Zetterström, R.H., Solomin, L., Arvidsson, M., Olson, L., Perlmann, T., Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice (1999) Exp Cell Res, 253, pp. 737-746
  • Wassarman, K.M., Lewandoski, M., Campbell, K., Joyner, A.L., Rubenstein, J.L., Martinez, S., Martin, G.R., Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function (1997) Development, 124, pp. 2923-2934
  • Wurst, W., Bally-Cuif, L., Neural plate patterning: Upstream and downstream of isthmic organizer (2001) Nat Rev Neurosci, 2, pp. 99-108
  • Ye, W., Shimamura, K., Rubenstein, J.L.R., Hynes, M.A., Rosenthal, A., FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate (1998) Cell, 93, pp. 755-766
  • Zhuang, X., Masson, J., Gingrich, J.A., Rayport, S., Hen, R., Targeted gene expression in dopamine and serotonin neurons of the mouse brain (2005) J Neurosci Methods, 143, pp. 27-32

Citas:

---------- APA ----------
Guo, C., Qiu, H.-Y., Shi, M., Huang, Y., Johnson, R.L., Rubinstein, M., Chen, S.-D.,..., Ding, Y.-Q. (2008) . Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons. Journal of Neuroscience, 28(52), 14097-14106.
http://dx.doi.org/10.1523/JNEUROSCI.3267-08.2008
---------- CHICAGO ----------
Guo, C., Qiu, H.-Y., Shi, M., Huang, Y., Johnson, R.L., Rubinstein, M., et al. "Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons" . Journal of Neuroscience 28, no. 52 (2008) : 14097-14106.
http://dx.doi.org/10.1523/JNEUROSCI.3267-08.2008
---------- MLA ----------
Guo, C., Qiu, H.-Y., Shi, M., Huang, Y., Johnson, R.L., Rubinstein, M., et al. "Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons" . Journal of Neuroscience, vol. 28, no. 52, 2008, pp. 14097-14106.
http://dx.doi.org/10.1523/JNEUROSCI.3267-08.2008
---------- VANCOUVER ----------
Guo, C., Qiu, H.-Y., Shi, M., Huang, Y., Johnson, R.L., Rubinstein, M., et al. Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons. J. Neurosci. 2008;28(52):14097-14106.
http://dx.doi.org/10.1523/JNEUROSCI.3267-08.2008