Artículo

Lioudyno, M.; Hiel, H.; Kong, J.-H.; Katz, E.; Waldman, E.; Parameshwaran-Iyer, S.; Glowatzki, E.; Fuchs, P.A. "A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells" (2004) Journal of Neuroscience. 24(49):11160-11164
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Abstract:

Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR.

Registro:

Documento: Artículo
Título:A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
Autor:Lioudyno, M.; Hiel, H.; Kong, J.-H.; Katz, E.; Waldman, E.; Parameshwaran-Iyer, S.; Glowatzki, E.; Fuchs, P.A.
Filiación:Center for Hearing and Balance, Dept. Otolaryngol.-Hd. Neck Surg., Johns Hopkins Univ. Sch. of Medicine, Baltimore, MD 21205-2195, United States
Department of Neuroscience, Johns Hopkins Univ. Sch. of Medicine, Baltimore, MD 21205-2195, United States
Inst. Invest. Ing. Genet. Y Biol. M., Consejo Nac. de Invest. Cie. Y Tec., Universidad de Buenos Aires, Buenos Aires 1428, Argentina
Johns Hopkins Univ. Sch. of Medicine, Traylor Building 521, 720 Rutland Avenue, Baltimore, MD 21205-2195, United States
Department of Physiology/Biophysics, University of California at Irvine, Irvine, CA 92697-4561, United States
Palabras clave:Acetylcholine; Calcium; Cochlea; Hair cell; Inhibition; Nicotinic; acetylcholine; ryanodine receptor; ryanodine receptor 1; unclassified drug; amplitude modulation; animal experiment; article; cochlea; controlled study; hair cell; nonhuman; priority journal; protein expression; rat; sarcoplasmic reticulum; synaptic membrane; Acetylcholine; Animals; Calcium; Electrophysiology; Endoplasmic Reticulum; Evoked Potentials; Hair Cells; Neural Inhibition; Patch-Clamp Techniques; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Ryanodine Receptor Calcium Release Channel; Synapses
Año:2004
Volumen:24
Número:49
Página de inicio:11160
Página de fin:11164
DOI: http://dx.doi.org/10.1523/JNEUROSCI.3674-04.2004
Título revista:Journal of Neuroscience
Título revista abreviado:J. Neurosci.
ISSN:02706474
CODEN:JNRSD
CAS:acetylcholine, 51-84-3, 60-31-1, 66-23-9; Acetylcholine, 51-84-3; Calcium, 7440-70-2; Potassium, 7440-09-7; Receptors, Nicotinic; Ryanodine Receptor Calcium Release Channel
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v24_n49_p11160_Lioudyno

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Citas:

---------- APA ----------
Lioudyno, M., Hiel, H., Kong, J.-H., Katz, E., Waldman, E., Parameshwaran-Iyer, S., Glowatzki, E.,..., Fuchs, P.A. (2004) . A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells. Journal of Neuroscience, 24(49), 11160-11164.
http://dx.doi.org/10.1523/JNEUROSCI.3674-04.2004
---------- CHICAGO ----------
Lioudyno, M., Hiel, H., Kong, J.-H., Katz, E., Waldman, E., Parameshwaran-Iyer, S., et al. "A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells" . Journal of Neuroscience 24, no. 49 (2004) : 11160-11164.
http://dx.doi.org/10.1523/JNEUROSCI.3674-04.2004
---------- MLA ----------
Lioudyno, M., Hiel, H., Kong, J.-H., Katz, E., Waldman, E., Parameshwaran-Iyer, S., et al. "A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells" . Journal of Neuroscience, vol. 24, no. 49, 2004, pp. 11160-11164.
http://dx.doi.org/10.1523/JNEUROSCI.3674-04.2004
---------- VANCOUVER ----------
Lioudyno, M., Hiel, H., Kong, J.-H., Katz, E., Waldman, E., Parameshwaran-Iyer, S., et al. A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells. J. Neurosci. 2004;24(49):11160-11164.
http://dx.doi.org/10.1523/JNEUROSCI.3674-04.2004