Artículo

Mudry, M.D.; Martinez-Flores, I.; Palermo, A.M.; Carballo, M.A.; Egozcue, J.; Garcia Caldes, M. "Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus" (2001) Teratogenesis Carcinogenesis and Mutagenesis. 21(3):197-205
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Abstract:

Parasitic illnesses is increasing all over the world, especially in developing countries, and metronidazole (MTZ) is the therapeutic agent usually administered to children as well as adults at the reproductive age. In this work, we propose an evaluation of MTZ in order to analyze the potential reproductive damage in females by using Rattus norvegicus (Sprague-Dawley) as an animal model. Adult female rats were mated after MTZ treatments, and they were sacrificed at 21 days of gestation. Different types of damage were evaluated by using mortality, phenotypic abnormalities and reproductive capacity as parameters, and were studied and scored in 70 adult specimens (450 g/bw). They were divided into five groups: a) untreated females as a control group; females treated with b) DMSO as a solvent control group or c) 500 mg/kg/bw of MTZ per day for 7 days as therapeutic dose (TD); d) a half therapeutic dose (HD); and e) a double therapeutic dose (DD). Pre-implantation death in MTZ-treated groups was not significantly different from controls. However, drug treatments significantly increased the frequency of post-implantation deaths and the dominant lethals were ranged between 12.0 % and 17.8 %. © 2001 Wiley-Liss, Inc.

Registro:

Documento: Artículo
Título:Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus
Autor:Mudry, M.D.; Martinez-Flores, I.; Palermo, A.M.; Carballo, M.A.; Egozcue, J.; Garcia Caldes, M.
Filiación:GIBE (Grupo de Investigacion en Biologia Evolutiva), Departamento de Biologia, Universidad de Buenos Aires (UBA), Argentina
CIGETOX (Centro de Investigaciones en Genetica Toxicologica), Departamento de Bioquimica Clinica, Universidad de Buenos Aires (UBA), Argentina
Departament de Biologia Cellular de Fisiologia i Dimmunologia, Unitat de Biologia (Medicina), Universitat Autonoma de Barcelona (UAB), Spain
CITEFA, Buenos Aires, Argentina
GIBE-Grupo de Inv. en Biologia Evolutiva, Depto. de Cs. Biologicas, Ciudad Universitaria, Pabellon II, (1428) Buenos Aires, Argentina
Palabras clave:Dominant lethality; Maternal exposure; Nitroimidazole; Post-implantation death; metronidazole; animal experiment; animal model; animal tissue; article; controlled study; embryotoxicity; environmental exposure; female; gestational age; mortality; nidation; nonhuman; phenotype; priority journal; rat; reproduction; Animals; Antitrichomonal Agents; Embryo; Embryo Implantation; Embryo Loss; Embryonic Development; Female; Fertility; Fetal Death; Fetus; Maternal Exposure; Metronidazole; Pregnancy; Rats; Rats, Sprague-Dawley; Reproduction; Animalia; Rattus norvegicus
Año:2001
Volumen:21
Número:3
Página de inicio:197
Página de fin:205
DOI: http://dx.doi.org/10.1002/tcm.1008
Título revista:Teratogenesis Carcinogenesis and Mutagenesis
Título revista abreviado:Teratog. Carcinog. Mutag.
ISSN:02703211
CODEN:TCMUD
CAS:Antitrichomonal Agents; Metronidazole, 443-48-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02703211_v21_n3_p197_Mudry

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Citas:

---------- APA ----------
Mudry, M.D., Martinez-Flores, I., Palermo, A.M., Carballo, M.A., Egozcue, J. & Garcia Caldes, M. (2001) . Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus. Teratogenesis Carcinogenesis and Mutagenesis, 21(3), 197-205.
http://dx.doi.org/10.1002/tcm.1008
---------- CHICAGO ----------
Mudry, M.D., Martinez-Flores, I., Palermo, A.M., Carballo, M.A., Egozcue, J., Garcia Caldes, M. "Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus" . Teratogenesis Carcinogenesis and Mutagenesis 21, no. 3 (2001) : 197-205.
http://dx.doi.org/10.1002/tcm.1008
---------- MLA ----------
Mudry, M.D., Martinez-Flores, I., Palermo, A.M., Carballo, M.A., Egozcue, J., Garcia Caldes, M. "Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus" . Teratogenesis Carcinogenesis and Mutagenesis, vol. 21, no. 3, 2001, pp. 197-205.
http://dx.doi.org/10.1002/tcm.1008
---------- VANCOUVER ----------
Mudry, M.D., Martinez-Flores, I., Palermo, A.M., Carballo, M.A., Egozcue, J., Garcia Caldes, M. Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus. Teratog. Carcinog. Mutag. 2001;21(3):197-205.
http://dx.doi.org/10.1002/tcm.1008