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Abstract:

Background: Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhoea before the age of 40. Inhibin α-subunit (INHα) gene is proposed as a candidate gene due to its role in negative feedback control of FSH. Methods: Polymorphism -16 C>T of INHα gene was studied in 61 POF patients and 82 controls above 40 years old (C > 40). Substitution 769G>A was studied in 59 POF patients, 76 C > 40 and 73 controls below 40 years old (C < 40). Results: No significant difference in risk of POF development for -16T allele was found when comparing idiopathic POF (I-POF) with C > 40 (Odds ratio = 1.46; 95% confidence interval = 0.63-3.19). Implication of -16C>T polymorphism in serum inhibin levels was analysed in 46 controls, and no significant differences (P > 0.05) were found between CC and CT + TT genotype groups when comparing either mid-follicular phase Pro-αC and inhibin B values or mid-luteal phase Pro-αC and inhibin A values. Heterozygosity for substitution 769G>A was found in 1 of 59 POF woman, 2 of 76 C > 40 and 6 of 73 C < 40. Presence of this su bstitution in a relevant number of control subjects is herein described for the first time. Conclusion: Our results indicate that -16C>T and 769G>A variants in INHα gene may not be associated to POF disease. © 2006 Oxford University Press.

Registro:

Documento: Artículo
Título:Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure
Autor:Sundblad, V.; Chiauzzi, V.A.; Andreone, L.; Campo, S.; Charreau, E.H.; Dain, L.
Filiación:Instituto de Biología y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490, Buenos Aires, Argentina
Centro de Investigaciones Endocrinológicas (CEDIE), Hospital de Niños R. Gutiérrez, Vuelta de Obligado 2490, Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Vuelta de Obligado 2490, Buenos Aires, Argentina
Centro Nacional de Genética Médica (ANLIS), Buenos Aires, Argentina
Palabras clave:Inhibin levels; Inhibin α-subunit gene; Premature ovarian failure; cytosine; follitropin; inhibin; inhibin A; inhibin B; thymine; adult; allele; alpha chain; amenorrhea; article; confidence interval; controlled study; DNA polymorphism; female; follicular phase; genotype; heterozygosity; human; major clinical study; negative feedback; nucleic acid base substitution; premature ovarian failure; risk assessment; statistical analysis
Año:2006
Volumen:21
Número:5
Página de inicio:1154
Página de fin:1160
DOI: http://dx.doi.org/10.1093/humrep/dei452
Título revista:Human Reproduction
Título revista abreviado:Hum. Reprod.
ISSN:02681161
CODEN:HUREE
CAS:cytosine, 71-30-7; follitropin, 9002-68-0; inhibin, 57285-09-3, 69494-61-7; inhibin B, 115088-91-0; thymine, 65-71-4
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_02681161_v21_n5_p1154_Sundblad.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02681161_v21_n5_p1154_Sundblad

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Citas:

---------- APA ----------
Sundblad, V., Chiauzzi, V.A., Andreone, L., Campo, S., Charreau, E.H. & Dain, L. (2006) . Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure. Human Reproduction, 21(5), 1154-1160.
http://dx.doi.org/10.1093/humrep/dei452
---------- CHICAGO ----------
Sundblad, V., Chiauzzi, V.A., Andreone, L., Campo, S., Charreau, E.H., Dain, L. "Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure" . Human Reproduction 21, no. 5 (2006) : 1154-1160.
http://dx.doi.org/10.1093/humrep/dei452
---------- MLA ----------
Sundblad, V., Chiauzzi, V.A., Andreone, L., Campo, S., Charreau, E.H., Dain, L. "Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure" . Human Reproduction, vol. 21, no. 5, 2006, pp. 1154-1160.
http://dx.doi.org/10.1093/humrep/dei452
---------- VANCOUVER ----------
Sundblad, V., Chiauzzi, V.A., Andreone, L., Campo, S., Charreau, E.H., Dain, L. Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure. Hum. Reprod. 2006;21(5):1154-1160.
http://dx.doi.org/10.1093/humrep/dei452