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Alternative splicing (AS) greatly expands the coding capacities of genomes by allowing the generation of multiple mature mRNAs from a limited number of genes. Although the massive switch in AS profiles that often accompanies variations in gene expression patterns occurring during cell differentiation has been characterized for a variety of models, their causes and mechanisms remain largely unknown. Here, we integrate foundational and recent studies indicating the AS switches that govern the processes of cell fate determination. We include some distinct AS events in pluripotent cells and somatic reprogramming and discuss new progresses on alternative isoform expression in adipogenesis, myogenic differentiation and stimulation of immune cells. Finally, we cover novel insights on AS mechanisms during neuronal differentiation, paying special attention to the role of chromatin structure. © 2017 WILEY Periodicals, Inc.


Documento: Artículo
Título:Alternative splicing switches: Important players in cell differentiation
Autor:Fiszbein, A.; Kornblihtt, A.R.
Filiación:Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET) and Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina
Palabras clave:alternative splicing; cell differentiation; chromatin structure; neuronal differentiation; RNA binding proteins; spliceosome; splicing factors; RNA; adipogenesis; alternative RNA splicing; cell differentiation; chromatin structure; embryonic stem cell; gene expression; human; immunocompetent cell; immunostimulation; muscle development; nerve cell differentiation; nuclear reprogramming; pluripotent stem cell; regulatory mechanism; Review; animal; cell differentiation; genetics; Alternative Splicing; Animals; Cell Differentiation; Humans
Título revista:BioEssays
Título revista abreviado:BioEssays
CAS:RNA, 63231-63-0


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Fiszbein, A. & Kornblihtt, A.R. (2017) . Alternative splicing switches: Important players in cell differentiation. BioEssays, 39(6).
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Fiszbein, A., Kornblihtt, A.R. "Alternative splicing switches: Important players in cell differentiation" . BioEssays 39, no. 6 (2017).
---------- MLA ----------
Fiszbein, A., Kornblihtt, A.R. "Alternative splicing switches: Important players in cell differentiation" . BioEssays, vol. 39, no. 6, 2017.
---------- VANCOUVER ----------
Fiszbein, A., Kornblihtt, A.R. Alternative splicing switches: Important players in cell differentiation. BioEssays. 2017;39(6).