Artículo

Wainszelbaum, M.; Isola, E.; Wilkowsky, S.; Cannata, J.J.B.; Florin-Christensen, J.; Florin-Christensen, M. "Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease" (2001) Biochemical Journal. 355(3):765-770
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Abstract:

We found that, as in African trypanosomes, endogenous phospholipase A1 (Plase A1) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A1 was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A1 emerges as a target to block pathogenesis in trypanosomal infections.

Registro:

Documento: Artículo
Título:Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease
Autor:Wainszelbaum, M.; Isola, E.; Wilkowsky, S.; Cannata, J.J.B.; Florin-Christensen, J.; Florin-Christensen, M.
Filiación:Department of Microbiology, University of Buenos Aires (UBA), School of Medicine, Paraguay 2155, piso 13, (RA-2111) Buenos Aires, Argentina
Ctr. for Bioenerg. Res. (CIBIERG), CONICET-UBA, Paraguay 2155, piso 16, (RA-2111) Buenos Aires, Argentina
Institute of Neuroscience (INEUCI), CONICET-UBA, Ciudad University, Pab. II, piso 4, (RA-1428) Buenos Aires, Argentina
Dept. of Vet. Microbiol. and P., Washington State University, Pullman, WA 99164-7040, United States
Palabras clave:Epimastigotes; Phosphatidylcholine; Phospholipids; Trypanosomiasis; Catalysis; Cells; Phospholipids; Tissue; Pathogenesis; Enzymes; phosphatidylcholine; phospholipase A1; phospholipid; phospholipase A; phospholipid; animal cell; article; catalysis; cell death; Chagas disease; deacylation; enzyme activity; enzyme purification; epimastigote; life cycle; lysosome; nonhuman; pathogenesis; priority journal; Trypanosoma cruzi; trypanosomiasis; animal; Chagas disease; enzymology; human; isolation and purification; lysosome; metabolism; parasitology; pathogenicity; physiology; Animalia; Protozoa; Trypanosoma; Trypanosoma cruzi; Animals; Catalysis; Chagas Disease; Humans; Lysosomes; Phospholipases A; Phospholipids; Trypanosoma cruzi
Año:2001
Volumen:355
Número:3
Página de inicio:765
Página de fin:770
DOI: http://dx.doi.org/10.1042/bj3550765
Título revista:Biochemical Journal
Título revista abreviado:Biochem. J.
ISSN:02646021
CODEN:BIJOA
CAS:phosphatidylcholine, 55128-59-1, 8002-43-5; phospholipase A1, 9043-29-2; Phospholipases A, EC 3.1.1.-; Phospholipids
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v355_n3_p765_Wainszelbaum

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Citas:

---------- APA ----------
Wainszelbaum, M., Isola, E., Wilkowsky, S., Cannata, J.J.B., Florin-Christensen, J. & Florin-Christensen, M. (2001) . Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease. Biochemical Journal, 355(3), 765-770.
http://dx.doi.org/10.1042/bj3550765
---------- CHICAGO ----------
Wainszelbaum, M., Isola, E., Wilkowsky, S., Cannata, J.J.B., Florin-Christensen, J., Florin-Christensen, M. "Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease" . Biochemical Journal 355, no. 3 (2001) : 765-770.
http://dx.doi.org/10.1042/bj3550765
---------- MLA ----------
Wainszelbaum, M., Isola, E., Wilkowsky, S., Cannata, J.J.B., Florin-Christensen, J., Florin-Christensen, M. "Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease" . Biochemical Journal, vol. 355, no. 3, 2001, pp. 765-770.
http://dx.doi.org/10.1042/bj3550765
---------- VANCOUVER ----------
Wainszelbaum, M., Isola, E., Wilkowsky, S., Cannata, J.J.B., Florin-Christensen, J., Florin-Christensen, M. Lysosomal phospholipase A1 in Trypanosoma cruzi: An enzyme with a possible role in the pathogenesis of Chagas' disease. Biochem. J. 2001;355(3):765-770.
http://dx.doi.org/10.1042/bj3550765