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Abstract:

A number of genes encoding bacterial glycosyltransferases have been sequenced during the last few years, but their low sequence similarity has prevented a straightforward grouping of these enzymes into families. The sequences of several bacterial α-mannosyltransferases have been compared using current alignment algorithms as well as hydrophobic cluster analysis (HCA). These sequences show a similarity which is significant but too low to be reliably aligned using automatic alignment methods. However, a region spanning approx. 270 residues in these proteins could be aligned by HCA, and several invariant amino acid residues were identified. These features were also found in several other glycosyltransferases, as well as in proteins of unknown function present in sequence databases. This similarity most probably reflects the existence of a family of proteins with conserved structural and mechanistic features. It is argued that the present IUBMB classification of glycosyltransferases could be complemented by a classification of these enzymes based on sequence similarities analogous to that which we proposed for glycosyl hydrolases.

Registro:

Documento: Artículo
Título:Towards a classification of glycosyltransferases based on amino acid sequence similarities: Prokaryotic α-mannosyltransferases
Autor:Geremia, R.A.; Petroni, E.A.; Ielpi, L.; Henrissat, B.
Filiación:Centre de Recherches sur les Macromolécules Végétales, Université Joseph Fourier, C.N.R.S., BP 53, 38041 Grenoble Cedex 9, France
Instituto de Investigaciones Bioquimicas 'Fundacion Campomar', Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Patricias Argentinas 435, (1405) Buenos Aires, Argentina
Palabras clave:glycosyltransferase; mannosyltransferase; algorithm; amino acid sequence; article; cluster analysis; data base; gene sequence; nonhuman; priority journal; protein family; Bacteria (microorganisms); Prokaryota
Año:1996
Volumen:318
Número:1
Página de inicio:133
Página de fin:138
DOI: http://dx.doi.org/10.1042/bj3180133
Título revista:Biochemical Journal
Título revista abreviado:BIOCHEM. J.
ISSN:02646021
CODEN:BIJOA
CAS:glycosyltransferase, 9033-07-2; mannosyltransferase, 9055-06-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v318_n1_p133_Geremia

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Citas:

---------- APA ----------
Geremia, R.A., Petroni, E.A., Ielpi, L. & Henrissat, B. (1996) . Towards a classification of glycosyltransferases based on amino acid sequence similarities: Prokaryotic α-mannosyltransferases. Biochemical Journal, 318(1), 133-138.
http://dx.doi.org/10.1042/bj3180133
---------- CHICAGO ----------
Geremia, R.A., Petroni, E.A., Ielpi, L., Henrissat, B. "Towards a classification of glycosyltransferases based on amino acid sequence similarities: Prokaryotic α-mannosyltransferases" . Biochemical Journal 318, no. 1 (1996) : 133-138.
http://dx.doi.org/10.1042/bj3180133
---------- MLA ----------
Geremia, R.A., Petroni, E.A., Ielpi, L., Henrissat, B. "Towards a classification of glycosyltransferases based on amino acid sequence similarities: Prokaryotic α-mannosyltransferases" . Biochemical Journal, vol. 318, no. 1, 1996, pp. 133-138.
http://dx.doi.org/10.1042/bj3180133
---------- VANCOUVER ----------
Geremia, R.A., Petroni, E.A., Ielpi, L., Henrissat, B. Towards a classification of glycosyltransferases based on amino acid sequence similarities: Prokaryotic α-mannosyltransferases. BIOCHEM. J. 1996;318(1):133-138.
http://dx.doi.org/10.1042/bj3180133