Artículo
Barañao, J.L.; Bley, M.A.; Batista, F.D.; Glikin, G.C. "A DNA topoisomerase i inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone" (1991) Biochemical Journal. 277(2):557-560
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Abstract:
Follicle-stimulating hormone (FSH), acting through a cyclic AMP-mediated mechanism, promotes differentiation of rat granulosa cells cultured in a defined medium. Camptothecin, a DNA topoisomerase I blocker, inhibited the increase in progesterone and oestradiol production stimulated by FSH. This effect was not due to non-specific inhibition of protein synthesis, as shown by measurement of [35S]methionine incorporation. A transient increase in DNA topoisomerase I activity was observed after 24 h of culture in the presence of FSH or dibutyryl cyclic AMP. Our results are consistent with a key role for DNA topoisomerase I in the modulation of gene expression by FSH in rat granulosa cells. © Portland Press Ltd. All rights reserved.
Registro:
| Documento: | Artículo |
| Título: | A DNA topoisomerase i inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone |
| Autor: | Barañao, J.L.; Bley, M.A.; Batista, F.D.; Glikin, G.C. |
| Filiación: | Instituto de Biologia y Medicina Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Vuelta de Obligado 2490, Buenos Aires, 1428, Argentina Lnstituto de Investigaciones en Ingenieria Genetica y Biologla Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Vuelta de Obligado 2490, Buenos Aires, 1428, Argentina |
| Palabras clave: | bucladesine; camptothecin; cell extract; DNA topoisomerase; estradiol; follitropin; progesterone; bucladesine; camptothecin; diethylstilbestrol; DNA topoisomerase; follitropin; insulin; methionine; camptothecin; DNA topoisomerase; estradiol; progesterone; animal cell; animal cell culture; Article; cell differentiation; comparative study; controlled study; enzyme activity; enzyme assay; female; granulosa cell; hormone synthesis; nonhuman; priority journal; protein synthesis; rat; animal; article; cell culture; cytology; drug antagonism; drug effect; enzymology; kinetics; metabolism; rat strain; DNA synthesis; gene expression regulation; hormonal regulation; topical drug administration; Animals; Bucladesine; Camptothecin; Cell Differentiation; Cells, Cultured; Diethylstilbestrol; DNA Topoisomerases, Type I; Female; Follicle Stimulating Hormone; Granulosa Cells; Insulin; Kinetics; Methionine; Protein Biosynthesis; Rats; Rats, Inbred Strains |
| Año: | 1991 |
| Volumen: | 277 |
| Número: | 2 |
| Página de inicio: | 557 |
| Página de fin: | 560 |
| Título revista: | Biochemical Journal |
| Título revista abreviado: | Biochem. J. |
| ISSN: | 02646021 |
| CODEN: | BIJOA |
| CAS: | bucladesine, 16980-89-5, 362-74-3; camptothecin, 7689-03-4; DNA topoisomerase, 80449-01-0; estradiol, 50-28-2; follitropin, 9002-68-0; progesterone, 57-83-0; diethylstilbestrol, 30498-85-2, 56-53-1; insulin, 9004-10-8; methionine, 59-51-8, 63-68-3, 7005-18-7; Bucladesine, 362-74-3; Camptothecin, 7689-03-4; Diethylstilbestrol, 56-53-1; DNA Topoisomerases, Type I, EC 5.99.1.2, 9002-68-0; Follicle Stimulating Hormone, 9002-68-0; Insulin, 11061-68-0, 7689-03-4; Methionine, 63-68-3, 7689-03-4 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v277_n2_p557_Baranao |
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Citas:
---------- APA ----------
Barañao, J.L., Bley, M.A., Batista, F.D. & Glikin, G.C. (1991) . A DNA topoisomerase i inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone. Biochemical Journal, 277(2), 557-560.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v277_n2_p557_Baranao [ ]
---------- CHICAGO ----------
Barañao, J.L., Bley, M.A., Batista, F.D., Glikin, G.C. "A DNA topoisomerase i inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone" . Biochemical Journal 277, no. 2 (1991) : 557-560.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v277_n2_p557_Baranao [ ]
---------- MLA ----------
Barañao, J.L., Bley, M.A., Batista, F.D., Glikin, G.C. "A DNA topoisomerase i inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone" . Biochemical Journal, vol. 277, no. 2, 1991, pp. 557-560.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v277_n2_p557_Baranao [ ]
---------- VANCOUVER ----------
Barañao, J.L., Bley, M.A., Batista, F.D., Glikin, G.C. A DNA topoisomerase i inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone. Biochem. J. 1991;277(2):557-560.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v277_n2_p557_Baranao [ ]
