De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207+ cells to vaccination site. The time-course behavior of CD207+ cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6-10 days, CD207+ cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c(-) CD207+ population, whose role remains to be determined. Whether CD207+ cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question. © 2014 Elsevier Ltd. All rights reserved.
| Documento: | Artículo |
| Título: | CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice |
| Autor: | Ruiz, M.S.; Mac Keon, S.; Campisano, S.; Bravo, A.I.; Gazzaniga, S.; Wainstok, R. |
| Filiación: | Dpto. de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina Fundación Instituto Leloir, IIBBA CONICET, Buenos Aires, Argentina Hospital Eva Perón, San Martín, Buenos Aires, Argentina |
| Idioma: | Inglés |
| Palabras clave: | CD207+ cells; Dendritic cells; Ectopic lymphoid tissue; Melanoma; Vaccine |
| Año: | 2014 |
| DOI: | http://dx.doi.org/10.1016/j.vaccine.2014.01.025 |
| Título revista: | Vaccine |
| Título revista abreviado: | Vaccine |
| ISSN: | 0264410X |
| CODEN: | VACCD |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0264410X_v_n_p_Ruiz |
