Abstract:
De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207+ cells to vaccination site. The time-course behavior of CD207+ cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6-10 days, CD207+ cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c(-) CD207+ population, whose role remains to be determined. Whether CD207+ cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question. © 2014 Elsevier Ltd.
Registro:
| Documento: |
Artículo
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| Título: | CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice |
| Autor: | Ruiz, M.S.; Mac Keon, S.; Campisano, S.; Bravo, A.I.; Gazzaniga, S.; Wainstok, R. |
| Filiación: | Dpto. de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina
Fundación Instituto Leloir, IIBBA CONICET, Buenos Aires, Argentina
Hospital Eva Perón, San Martín, Buenos Aires, Argentina
|
| Palabras clave: | CD207+ cells; Dendritic cells; Ectopic lymphoid tissue; Melanoma; Vaccine; CD207(+) cells; Dendritic cells; Ectopic lymphoid tissue; Melanoma; Vaccine; Animals; Antigens, Surface; Cancer Vaccines; Cell Movement; Dendritic Cells; Lectins, C-Type; Lymph Nodes; Lymphoid Tissue; Mannose-Binding Lectins; Melanoma; Mice; Mice, Inbred C57BL; T-Lymphocytes |
| Año: | 2014
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| Volumen: | 32
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| Número: | 11
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| Página de inicio: | 1229
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| Página de fin: | 1232
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| DOI: |
http://dx.doi.org/10.1016/j.vaccine.2014.01.025 |
| Título revista: | Vaccine
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| Título revista abreviado: | Vaccine
|
| ISSN: | 0264410X
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| CODEN: | VACCD
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| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0264410X_v32_n11_p1229_Ruiz |
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Citas:
---------- APA ----------
Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S. & Wainstok, R.
(2014)
. CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice. Vaccine, 32(11), 1229-1232.
http://dx.doi.org/10.1016/j.vaccine.2014.01.025---------- CHICAGO ----------
Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S., Wainstok, R.
"CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice"
. Vaccine 32, no. 11
(2014) : 1229-1232.
http://dx.doi.org/10.1016/j.vaccine.2014.01.025---------- MLA ----------
Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S., Wainstok, R.
"CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice"
. Vaccine, vol. 32, no. 11, 2014, pp. 1229-1232.
http://dx.doi.org/10.1016/j.vaccine.2014.01.025---------- VANCOUVER ----------
Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S., Wainstok, R. CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice. Vaccine. 2014;32(11):1229-1232.
http://dx.doi.org/10.1016/j.vaccine.2014.01.025
