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Montaner, A.D.; De Nichilo, A.; Elias, F.; Rodríguez, J.M.; Fló, J.M.; López, R.A.; Zorzopulos, J.; Frank, R. "Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route" (2006) Vaccine. 24(11):1889-1896
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Abstract:

Forty-five GM1-binding peptides were identified using phage-displayed peptides libraries of random peptides. Most have a motif containing a hydrophobic amino acid followed by a serine (S). Based on a GM1-binding assays, two of these GM1-binding peptides (named 15 and 40) were chosen to investigate its immunostimulatory properties when chemically coupled to antigens. Mice intra-nasally (i.n.) vaccinated with some of these complexes developed a better local and systemic antibody response than mice i.n. vaccinated with the respective uncoupled antigens. The efficiency of the complex GM 1-binding peptide-antigen strongly depends on the composition and structure of both of the components of the complex. © 2005 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route
Autor:Montaner, A.D.; De Nichilo, A.; Elias, F.; Rodríguez, J.M.; Fló, J.M.; López, R.A.; Zorzopulos, J.; Frank, R.
Filiación:Instituto de Investigaciones Biomédicas, Fundación Pablo Cassará, Saladillo 2452, Buenos Aires C1440FFX, Argentina
Immunotech S.A., Buenos Aires, Argentina
Departamento de Química Biológica, FCEN, Universidad de Buenos Aires, Argentina
Department of Chemical Biology, GBF (German Research Centre for Biotechnology), Braunschweig, Germany
Palabras clave:GM1-binding peptides; Mucosal adjuvants; Phage display; bromacetyl beta alanyl beta alanylarginylseryllysylprolylprolyleucylserylprolylleucylglycyltyrosinamide; bromacetyl beta alanyl beta alanylprolylprolylserylprolylserylvalylserylhistidylarginylthreonyltyrosinamide; ganglioside GM1; immunological adjuvant; peptide; peptide library; serine; unclassified drug; amino acid composition; animal cell; animal experiment; antibody response; article; binding assay; controlled study; immunostimulation; inoculation; mouse; nonhuman; phage display; priority journal; protein motif; Adjuvants, Immunologic; Administration, Intranasal; Animals; Antibodies, Bacterial; Antibodies, Viral; Antigens, Bacterial; Antigens, Viral; Bronchoalveolar Lavage Fluid; Cell Wall; Enzyme-Linked Immunosorbent Assay; G(M1) Ganglioside; Hemagglutinin Glycoproteins, Influenza Virus; Immunoglobulin A; Immunoglobulin G; Influenza Vaccines; Mice; Mice, Inbred BALB C; Neuraminidase; Peptide Library; Peptides; Protein Binding; Streptococcus pneumoniae
Año:2006
Volumen:24
Número:11
Página de inicio:1889
Página de fin:1896
DOI: http://dx.doi.org/10.1016/j.vaccine.2005.10.037
Título revista:Vaccine
Título revista abreviado:Vaccine
ISSN:0264410X
CODEN:VACCD
CAS:ganglioside GM1, 37758-47-7; serine, 56-45-1, 6898-95-9; Adjuvants, Immunologic; Antibodies, Bacterial; Antibodies, Viral; Antigens, Bacterial; Antigens, Viral; G(M1) Ganglioside, 37758-47-7; Hemagglutinin Glycoproteins, Influenza Virus; Immunoglobulin A; Immunoglobulin G; Influenza Vaccines; Neuraminidase, EC 3.2.1.18; Peptide Library; Peptides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0264410X_v24_n11_p1889_Montaner

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Citas:

---------- APA ----------
Montaner, A.D., De Nichilo, A., Elias, F., Rodríguez, J.M., Fló, J.M., López, R.A., Zorzopulos, J.,..., Frank, R. (2006) . Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route. Vaccine, 24(11), 1889-1896.
http://dx.doi.org/10.1016/j.vaccine.2005.10.037
---------- CHICAGO ----------
Montaner, A.D., De Nichilo, A., Elias, F., Rodríguez, J.M., Fló, J.M., López, R.A., et al. "Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route" . Vaccine 24, no. 11 (2006) : 1889-1896.
http://dx.doi.org/10.1016/j.vaccine.2005.10.037
---------- MLA ----------
Montaner, A.D., De Nichilo, A., Elias, F., Rodríguez, J.M., Fló, J.M., López, R.A., et al. "Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route" . Vaccine, vol. 24, no. 11, 2006, pp. 1889-1896.
http://dx.doi.org/10.1016/j.vaccine.2005.10.037
---------- VANCOUVER ----------
Montaner, A.D., De Nichilo, A., Elias, F., Rodríguez, J.M., Fló, J.M., López, R.A., et al. Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route. Vaccine. 2006;24(11):1889-1896.
http://dx.doi.org/10.1016/j.vaccine.2005.10.037