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Abstract:

BACKGROUND: The reproducibility of brachial artery flow-mediated vasodilatation (FMD) is limited by the operator dependence of most measurement methods. METHODS: A new automated computerized analysis of brachial artery ultrasound scan providing a continuous evolution of the diameter during acute hyperemia, reactive to short hyperemia of the foream and hand, was tested in 10 normal volunteers and 26 asymptomatic patients with cardiovascular risk factors such as hypertension, hypercholesterolemia, heavy smoking, history of premature coronary heart disease and the metabolic syndrome. FMD was the percentage of the maximum hyperemic diastolic diameter from baseline. Within-reading variations in FMD and diameters were assessed by reading one scan from the same subject twice by two observers. The within-subject variability of FMD was assessed by analysing two repeated measurements in the same subject by the same operator 1 h, 1 week or 1 month apart. RESULTS: Coefficients of variation (CV) of repeated FMD readings were 7.5% in normal volunteers and 6.9% in patients with risk factors. CV of repeated FMD measurements 1 h apart were 7.8% in normal volunteers and 16.5% in patients with risk factors. In normal volunteers, CV of repeated FMD measurements 1 week apart was 9.6%, and in patients with risk factors CV of repeated FMD measurement 1 month apart was 18.1%. CONCLUSION: This method overcomes the variability of FMD measurement seen with conventional manual analysis in normal volunteers, and to a lesser extent in patients with major cardiovascular risk factors, thus supporting its clinical applicability to patients with disease conditions. © 2007 Lippincott Williams & Wilkins, Inc.

Registro:

Documento: Artículo
Título:New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements
Autor:Craiem, D.; Chironi, G.; Gariepy, J.; Miranda-Lacet, J.; Levenson, J.; Simon, A.
Filiación:Universidad Favaloro, Facultad de Ciencias Exactas Y Naturales, Buenos Aires, Argentina
AP-HP, Hôpital Européen Georges Pompidou (Site Broussais), Université René Descartes - Faculté de Médecine Paris 5, Paris, France
Centre de Médecine Préventive Cardiovasculaire, Hôpital Broussais, 96 rue Didot, F-75674 Paris, France
Palabras clave:Brachial artery; Endothelium; Ultrasound; Vasodilatation; adult; article; automation; B scan; brachial artery; brachial artery flow mediated vasodilation; cardiovascular risk; clinical article; computer analysis; computer program; controlled study; female; forearm; hand; human; hypercholesterolemia; hyperemia; hypertension; ischemic heart disease; male; measurement; metabolic syndrome X; monitoring; priority journal; reproducibility; smoking; ultrasound; vasodilatation; Adult; Blood Flow Velocity; Brachial Artery; Cardiovascular Diseases; Female; Humans; Hypercholesterolemia; Hyperemia; Hypertension; Image Interpretation, Computer-Assisted; Male; Metabolic Syndrome X; Observer Variation; Reference Values; Reproducibility of Results; Research Design; Risk Factors; Smoking; Software; Time Factors; Vasodilation
Año:2007
Volumen:25
Número:1
Página de inicio:133
Página de fin:140
DOI: http://dx.doi.org/10.1097/HJH.0b013e3280109287
Título revista:Journal of Hypertension
Título revista abreviado:J. Hypertens.
ISSN:02636352
CODEN:JOHYD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02636352_v25_n1_p133_Craiem

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Citas:

---------- APA ----------
Craiem, D., Chironi, G., Gariepy, J., Miranda-Lacet, J., Levenson, J. & Simon, A. (2007) . New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements. Journal of Hypertension, 25(1), 133-140.
http://dx.doi.org/10.1097/HJH.0b013e3280109287
---------- CHICAGO ----------
Craiem, D., Chironi, G., Gariepy, J., Miranda-Lacet, J., Levenson, J., Simon, A. "New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements" . Journal of Hypertension 25, no. 1 (2007) : 133-140.
http://dx.doi.org/10.1097/HJH.0b013e3280109287
---------- MLA ----------
Craiem, D., Chironi, G., Gariepy, J., Miranda-Lacet, J., Levenson, J., Simon, A. "New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements" . Journal of Hypertension, vol. 25, no. 1, 2007, pp. 133-140.
http://dx.doi.org/10.1097/HJH.0b013e3280109287
---------- VANCOUVER ----------
Craiem, D., Chironi, G., Gariepy, J., Miranda-Lacet, J., Levenson, J., Simon, A. New monitoring software for larger clinical application of brachial artery flow-mediated vasodilatation measurements. J. Hypertens. 2007;25(1):133-140.
http://dx.doi.org/10.1097/HJH.0b013e3280109287