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Abstract:

The influence of prostaglandins (PGs) on the metabolism of 3H-noradrenaline in isolated uterine, horns from ovariectomized rats exposed to acetylsalicylic acid was explored. PGE1 and PGE2 (10 nM) increased both the total tritium and the 3H-O-methylated deaminated metabolites from the spontaneous outflow. PGE2 augmented 3H-normetanephrine whereas PGE1 reduced the 3H-3,4-dihydroxyphenylglycol fraction. The 3H-noradrenaline fraction from the spontaneous outflow of tritium was enhanced by PGE2 and PGI2 (10 nM). On the other hand PGF2α (10 nM-1 uM) did not change the metabolism of 3H-noradrenaline. The present findings suggest a possible modulation of noradrenaline metabolism by some PGs on the isolated rat uterus from ovariectomized rats. © 1982 Longman Group Ltd.

Registro:

Documento: Artículo
Título:Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals
Autor:Fernández Pardal, J.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios, Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina
Palabras clave:3,4 dihydroxyphenylethylene glycol; 4 hydroxy 3 methoxyphenylethylene glycol; drug derivative; noradrenalin; normetadrenalin; prostacyclin; prostaglandin; prostaglandin E; prostaglandin E1; prostaglandin E2; acetylsalicylic acid; alpha adrenergic receptor; noradrenalin; prostacyclin; prostaglandin; prostaglandin e1; prostaglandin e2; prostaglandin f2 alpha; radioisotope; animal; article; castration; drug effect; female; in vitro study; metabolism; methylation; rat; rat strain; uterus; animal experiment; autonomic nervous system; drug metabolism; endocrine system; female genital system; noradrenalin h 3; ovariectomy; uterus; Alprostadil; Animal; Castration; Dinoprostone; Epoprostenol; Female; In Vitro; Methoxyhydroxyphenylglycol; Methylation; Norepinephrine; Normetanephrine; Prostaglandins; Prostaglandins E; Rats; Rats, Inbred Strains; Uterus
Año:1982
Volumen:9
Número:3
Página de inicio:341
Página de fin:348
DOI: http://dx.doi.org/10.1016/S0262-1746(82)80021-8
Título revista:Prostaglandins, Leukotrienes and Medicine
Título revista abreviado:Prostaglandins Leukotrienes Med.
ISSN:02621746
CODEN:PLMED
CAS:3,4 dihydroxyphenylethylene glycol, 3343-19-9; 4 hydroxy 3 methoxyphenylethylene glycol, 534-82-7; noradrenalin, 1407-84-7, 51-41-2; normetadrenalin, 97-31-4; prostacyclin, 35121-78-9, 61849-14-7; prostaglandin E, 11042-70-9; prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; prostaglandin F2 alpha, 551-11-1; Alprostadil, 745-65-3; dihydroxyphenylethylene glycol, 3343-19-9; Dinoprostone, 363-24-6; Epoprostenol, 35121-78-9; Methoxyhydroxyphenylglycol, 534-82-7; Norepinephrine, 51-41-2; Normetanephrine, 97-31-4; Prostaglandins E; Prostaglandins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v9_n3_p341_FernandezPardal

Referencias:

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  • Gimeno, Sterin-Speziale, Landa, Bonacossa, Gimeno, Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? (1979) Prostaglandins, 17, p. 673
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  • Moncada, Gryglewsky, Bunting, Vane, An enzyme isolated from arteries transforms prostaglandin endoperoxides, to an unstable substance that inhibits platelet aggregation (1976) Nature (Lond.), 263, p. 663
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Citas:

---------- APA ----------
Fernández Pardal, J., Gimeno, M.F. & Gimeno, A.L. (1982) . Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals. Prostaglandins, Leukotrienes and Medicine, 9(3), 341-348.
http://dx.doi.org/10.1016/S0262-1746(82)80021-8
---------- CHICAGO ----------
Fernández Pardal, J., Gimeno, M.F., Gimeno, A.L. "Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals" . Prostaglandins, Leukotrienes and Medicine 9, no. 3 (1982) : 341-348.
http://dx.doi.org/10.1016/S0262-1746(82)80021-8
---------- MLA ----------
Fernández Pardal, J., Gimeno, M.F., Gimeno, A.L. "Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals" . Prostaglandins, Leukotrienes and Medicine, vol. 9, no. 3, 1982, pp. 341-348.
http://dx.doi.org/10.1016/S0262-1746(82)80021-8
---------- VANCOUVER ----------
Fernández Pardal, J., Gimeno, M.F., Gimeno, A.L. Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectiomized animals. Prostaglandins Leukotrienes Med. 1982;9(3):341-348.
http://dx.doi.org/10.1016/S0262-1746(82)80021-8