Artículo
Fernandez-Pardal, J.; Gimeno, M.F.; Gimeno, A.L. "The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle" (1985) Prostaglandins, Leukotrienes and Medicine. 19(1):1-10
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Abstract:
The influences of acetylsalicylic acid (ASA) and of prostaglandins (PGs) E1, E2 or F2α metabolism the spontaneous total tritium efflux from and on the metabolism of 3H-norepinephrine (3H-NE) in the walls of sow Graafian follicles isolated during two different stages of the sex cycle, were studied. The total 3H efflux from preparations obtained in proestrus (early preovulatory period) was higher than the output from diestrous tissues. This augmentation observed in proestrous samples, mainly attributable to a greater metabolism of 3H-NE, was expressed by an enhanced 3H-efflux corresponding to 3H-0-methylated (3H-OMDA) and 3H-normetanephrine (3H-NMN) metabolites. With regard to 3H-labelled compounds retained in the tissue, the follicular walls in proestrus (as compared to those in diestrus), retained more 3H-NMN fraction and less 3H-NE; an augmented metabolism of 3H-NE is suggested for the proestrous follicles. In the presence of ASA (2.2 × 10-4 M) the above mentioned profiles of early preovulatory follicles, disappeared and the addition in vitro of PGE1 or PGE2 (10-8 M), but not of PGF2α (10-8 M to 10-6 m) was able to reverse the influence of ASA. These findings suggest the involvement of estrogens in the metabolism of 3H-NE by sow ovarian follicles and moreover, they also appear to indicate the requirement for some PGs, such as PGE1 and PGE2, generated by cells of the follicular wall. © 1985.
Registro:
| Documento: | Artículo |
| Título: | The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle |
| Autor: | Fernandez-Pardal, J.; Gimeno, M.F.; Gimeno, A.L. |
| Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cienificas y Tecnicas de la Republica Argentina (CONICET). Serra, 1414 Buenos Aires, Argentina |
| Palabras clave: | acetylsalicylic acid; noradrenalin; prostaglandin derivative; prostaglandin E; prostaglandin E1; prostaglandin E2; prostaglandin F; prostaglandin F2 alpha; acetylsalicylic acid; noradrenalin; prostaglandin; prostaglandin e1; prostaglandin e2; prostaglandin f2 alpha; radioisotope; animal; article; diestrus; drug effect; estrus; female; in vitro study; metabolism; ovary follicle; pregnancy; proestrus; swine; cattle; drug accumulation; drug efficacy; endocrine system; female genital system; nonhuman; noradrenalin h 3; ovary; ovary follicle; priority journal; sexual cycle; Alprostadil; Animal; Aspirin; Diestrus; Dinoprost; Dinoprostone; Estrus; Female; In Vitro; Norepinephrine; Ovarian Follicle; Pregnancy; Proestrus; Prostaglandins E; Prostaglandins F; Prostaglandins, Synthetic; Support, Non-U.S. Gov't; Swine |
| Año: | 1985 |
| Volumen: | 19 |
| Número: | 1 |
| Página de inicio: | 1 |
| Página de fin: | 10 |
| DOI: | http://dx.doi.org/10.1016/0262-1746(85)90156-8 |
| Título revista: | Prostaglandins, Leukotrienes and Medicine |
| Título revista abreviado: | Prostaglandins Leukotrienes Med. |
| ISSN: | 02621746 |
| CODEN: | PLMED |
| CAS: | acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; noradrenalin, 1407-84-7, 51-41-2; prostaglandin E, 11042-70-9; prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Alprostadil, 745-65-3; Aspirin, 50-78-2; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Norepinephrine, 51-41-2; Prostaglandins E; Prostaglandins F; Prostaglandins, Synthetic |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v19_n1_p1_FernandezPardal |
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Citas:
---------- APA ----------
Fernandez-Pardal, J., Gimeno, M.F. & Gimeno, A.L. (1985) . The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle. Prostaglandins, Leukotrienes and Medicine, 19(1), 1-10.http://dx.doi.org/10.1016/0262-1746(85)90156-8
---------- CHICAGO ----------
Fernandez-Pardal, J., Gimeno, M.F., Gimeno, A.L. "The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle" . Prostaglandins, Leukotrienes and Medicine 19, no. 1 (1985) : 1-10.http://dx.doi.org/10.1016/0262-1746(85)90156-8
---------- MLA ----------
Fernandez-Pardal, J., Gimeno, M.F., Gimeno, A.L. "The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle" . Prostaglandins, Leukotrienes and Medicine, vol. 19, no. 1, 1985, pp. 1-10.http://dx.doi.org/10.1016/0262-1746(85)90156-8
---------- VANCOUVER ----------
Fernandez-Pardal, J., Gimeno, M.F., Gimeno, A.L. The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle. Prostaglandins Leukotrienes Med. 1985;19(1):1-10.http://dx.doi.org/10.1016/0262-1746(85)90156-8
