Artículo
Abstract:
The present study reports findings on: a) the action of histamine (H) on the spontaneous motility of the uterus isolated from rats during four different stages of the sex cycle; b) the relevance of endogenous and exogenous prostaglandins (PGs) for the inotropic effect of H and c) the relationships between these factors and the generation and release of PGs in rat uterine horns obtained during proestrus, estrus, metestrus and diestrus. Cumulative done-response curves for H, in strips isolated from proestrous rats, showed that the agonist inhibited, at all the concentrations tested, spontaneous myometrial contractions, evoking a maximum effect (100% inhibition) at 10-5M. Incubation with acetylsalicylic acid (ASA; 10-4M) did not modify the dose-response curve for H. In strips from estrous rats, the maximum effect of H was obtained at 10-3M and, after incubating with ASA, the control dose-response curve for H was shifted to the left. A subthreshold dose of PGE2 (10-9M), reversed completely the action of ASA on H uterine responses, whereas PGF2α was not effective. Dose-response curves for H, in uterine strips isolated from metestrous rats, showed the maximum effect (85% of inhibition) at 10-3M. Incubation with ASA, shifted the curve to the left and, the maximum effect increased up to 100% inhibition. A subthreshold dose (10-9M) of PGE2 or of PGF2α shifted to the right the dose-response curve for the amine. In uterine strips isolated from diestrous rats the maximum inotropic action of H evoked only 75% of contractile inhibition and, in the presence the ASA, this influence reached 100%; the dose-response for the agonist being shifted to the left. Both PGE2 or PGF2α, added in the presence of ASA, abolished the displacement evoked by ASA on the control dose-response curve for H. A significant correlation between the tissue output of "PGE-like material" into the bathing solution and the ED50 for the contractile influence of H, was also detected. On the contrary the release of "PGF2α-like material" did not correlate with the ED50 for H. The foregoing results suggest that some endogenous uterine prostaglandins of the 2 series, modulate the depressive inotropic action of H in isolated uterine strips, depending on the ovarian hormonal status of the animals. © 1984.
Registro:
| Documento: | Artículo |
| Título: | Prostaglandins and ovarian factors as modulators of the negative inotropic action of histamine in the isolated rat uterus |
| Autor: | Viggiano, M.; Dveksler, G.; Franchi, A.M.; Gimeno, M.F.; Gimeno, A.L. |
| Filiación: | Centro de Estudios Farmacológicos y de Principias Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina |
| Palabras clave: | acetylsalicylic acid; histamine; prostaglandin; prostaglandin e2; prostaglandin f2 alpha; animal cell; drug efficacy; endocrine system; estrus; female genital system; muscle; nonhuman; ovary; priority journal; rat; smooth muscle; uterus; Animals; Aspirin; Depression, Chemical; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Estrus; Female; Histamine; Pregnancy; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Uterine Contraction; Uterus; Animalia |
| Año: | 1984 |
| Volumen: | 16 |
| Número: | 3 |
| Página de inicio: | 267 |
| Página de fin: | 278 |
| DOI: | http://dx.doi.org/10.1016/0262-1746(84)90185-9 |
| Título revista: | Prostaglandins, Leukotrienes and Medicine |
| Título revista abreviado: | Prostaglandins Leukotrienes Med. |
| ISSN: | 02621746 |
| CODEN: | PLMED |
| CAS: | acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; histamine, 51-45-6, 56-92-8, 93443-21-1; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Aspirin, 50-78-2; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Histamine, 51-45-6; Prostaglandins E; Prostaglandins F |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v16_n3_p267_Viggiano |
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Citas:
---------- APA ----------
Viggiano, M., Dveksler, G., Franchi, A.M., Gimeno, M.F. & Gimeno, A.L. (1984) . Prostaglandins and ovarian factors as modulators of the negative inotropic action of histamine in the isolated rat uterus. Prostaglandins, Leukotrienes and Medicine, 16(3), 267-278.http://dx.doi.org/10.1016/0262-1746(84)90185-9
---------- CHICAGO ----------
Viggiano, M., Dveksler, G., Franchi, A.M., Gimeno, M.F., Gimeno, A.L. "Prostaglandins and ovarian factors as modulators of the negative inotropic action of histamine in the isolated rat uterus" . Prostaglandins, Leukotrienes and Medicine 16, no. 3 (1984) : 267-278.http://dx.doi.org/10.1016/0262-1746(84)90185-9
---------- MLA ----------
Viggiano, M., Dveksler, G., Franchi, A.M., Gimeno, M.F., Gimeno, A.L. "Prostaglandins and ovarian factors as modulators of the negative inotropic action of histamine in the isolated rat uterus" . Prostaglandins, Leukotrienes and Medicine, vol. 16, no. 3, 1984, pp. 267-278.http://dx.doi.org/10.1016/0262-1746(84)90185-9
---------- VANCOUVER ----------
Viggiano, M., Dveksler, G., Franchi, A.M., Gimeno, M.F., Gimeno, A.L. Prostaglandins and ovarian factors as modulators of the negative inotropic action of histamine in the isolated rat uterus. Prostaglandins Leukotrienes Med. 1984;16(3):267-278.http://dx.doi.org/10.1016/0262-1746(84)90185-9
