Artículo
Abstract:
The purpose of the present study was to explore whether, the stimulating contractile action of angiotensin II (AII) or of angiotensin I (AI), in uterine strips isolated from rats, either spayed or spayed and injected with 17-β estradiol, was somehow linked to tissue generated prostaglandine (PGs). Indomethacin (10-6M), shifted to the left the dose-response curve for AII in preparations from ovariectomized animals; augmenting both, the efficacy and the potency of the agonist. Dose-response curves for All were also explored in the presence of subthreshold concentrations of several exogenous PGs. PGE2 (10-9M) completely abolished the influence of indomethacin on the cu ve for AII; PGD2 (10-9M) did not evoke effects and PGF2α (10-9M) only altered the threshold dose, the rest of the curve remaining similar to that obtained with indomethacin alone. The cumulative dose-response curve for AI, in strips isolated from ovariectomized rats, was comparable to that for AII and, the presence of indomethacin, only reduced the concentration for the threshold action of AI, in comparison to controls. Captopril (100 ng/ml), shifted to the right the dose-response curve for AI and indomethacin failed to alter the effects of AI in the presence of captopril. In strips isolated from ovariectomized rats, injected with 17-β estradiol, the low concentration points of the dose-response curve for All were shifted to the left of those for the agonist in control preparations from spayed rats not treated with estradiol. Furthermore, indomethacin failed to alter the responses to AII in strips from spayed animals injected with 17-β estradiol. The foregoing results document that an inhibitor of tissue PGs synthesis,namely indomethacin, is able to modify the dose-response curve for AII, rather than that for AI, in the uterus from ovariectomized rats, but not in preparations from spayed animals treated with estrediol. This, as well as the effect of a subthreshold dose of PGs, suggest that a minimun of PGE2 is required for the contractile influence of All and not for that of AI. Moreover, the absence of estrogen dominance appears, as well, as a crucial factor for the action of AII. © 1984.
Registro:
| Documento: | Artículo |
| Título: | Prostaglandins and the contractile effect of angiotensin i and ii in the uterus isolated from ouariectomized rats. influence*of indo methacin and 17-β estradiol |
| Autor: | Chaud, M.; Viggiano, M.; Gimeno, M.F.; Gimeno, A.L. |
| Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Necional de Investigociones Científicas y Técnicas de la Republics Argentina (CONICET) Serrano 665/69, (1414) Buenos Aires, Argentina ( Supported by Grant 6638 from CONICET). |
| Palabras clave: | angiotensin; captopril; estradiol; indometacin; prostaglandin; prostaglandin d2; prostaglandin e2; prostaglandin f2 alpha; animal cell; endocrine system; female genital system; muscle; nonhuman; priority journal; rat; smooth muscle; smooth muscle contraction; uterus; Angiotensin I; Angiotensin II; Angiotensins; Animal; Captopril; Castration; Estradiol; Female; In Vitro; Indomethacin; Prostaglandins; Rats; Rats, Inbred Strains; Uterine Contraction; Uterus |
| Año: | 1984 |
| Volumen: | 16 |
| Número: | 2 |
| Página de inicio: | 225 |
| Página de fin: | 234 |
| DOI: | http://dx.doi.org/10.1016/0262-1746(84)90073-8 |
| Título revista: | Prostaglandins, Leukotrienes and Medicine |
| Título revista abreviado: | Prostaglandins Leukotrienes Med. |
| ISSN: | 02621746 |
| CODEN: | PLMED |
| CAS: | angiotensin, 11128-99-7, 1407-47-2; captopril, 62571-86-2; estradiol, 50-28-2; indometacin, 53-86-1, 74252-25-8, 7681-54-1; prostaglandin D2, 41598-07-6; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Angiotensin I, 9041-90-1; Angiotensin II, 11128-99-7; Angiotensins; Captopril, 62571-86-2; Estradiol, 50-28-2; Indomethacin, 53-86-1; Prostaglandins |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v16_n2_p225_Chaud |
Referencias:
- Kheirellah, Pharmacology of angiotensin (1971) Kidney Hormones, p. 129. , J.W. Fisher, Academic Press, New York
- Page, Bumps, Angiotensin (1961) Physiol.Rev., 41, p. 331
- Regoli, Rioux, Park, Pharmacology of angiotensin (1974) Pharmacol.Rev., 26, p. 69
- Papadimitriou, Worcel, Dose-response curves for angiotensin II and synthetic analogues in three types of smooth muscle existence of different rates for angiotensin II (1974) British Journal of Pharmacology, 50, p. 291
- Lin, Goodfriend, Angiotensin receptors (1970) Am.J.Physiol., 218, p. 1319
- Capponi, Catt, Angiotensin II receptors in adrenal cortex and uterus: binding and activation properties of angiotensin analogues (1979) J.Biol.Chem., 254, p. 5120
- Ng, Vane, Conversion of angiotensin I to angiotensin II (1967) Nature, 21, p. 762
- Biron, Huggins, Pulmonary activation of synthetic angiotensin I (1968) Life Sci., 7, p. 965
- Disalvo, Montefusco, Conversion of angiotensin I to angiotensin II in the canine mesenteric circulation (1971) Am.J.Physiol., 221, p. 1576
- Britton, Disalvo, Effects of angiotensin I and angiotensin II on hindlimb and coronary vascular resistance (1973) Am.J.Physiol., 225, p. 1226
- Bumpus, Kheirellah, Arakewa, Page, Smeby, The relationship of structure to pressor and oxytocic actions of isoleucine5 angio tension octapeptide (1961) Biochem.Biophys.Acta, 46, p. 38
- Aiken, Vane, Renin-angiotensin system: inhibition of converting enzyme in isolated tissues (1970) Nature, 228, p. 30
- Needlemen, Johnson, Vine, Flanigan, Marahell, Pharmacology of antagonists of angiotensin octapeptide and various analogues (1972) Circulation Research, 31, p. 862
- McGiff, Crowshaw, Terragno, Lonigro, Release of a prostaglandin-like substance into renal venous blood in response to angiotensin II (1970) Circulation Res., 26-27 (1), p. 121
- Peskar, Hertting, Release of prostaglandins from isolated cat spleen by angiotensin and vasopressin (1973) Naunyn-Schmiedeberg's Archives of Pharmacology, 279, p. 277
- Ferreira, Herman, Vane, Prostaglandin generation maintains the smooth muscle tone of the rabbit isolated jejunum (1972) Br.J.Phermecol., 44, p. 328
- Blumberg, Denny, Nishikewa, Pure, Marshall, Needleman, Angiotensin III-induced prosteglandin release (1976) Prostaglandins, 11, p. 195
- Desjardins-Giasson, Gutkowska, Garcia, Genest, Effect of angiotensin II and norepinephrine on release of prostaglandin E2 and 12 by the perfused rat mesenteric artery (1982) Prostaglandins, 24, p. 105
- Gimeno, Sterin-Speziale, Landa, Bonacosse, Gimeno, Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? (1979) Prostaglandins, 17, p. 673
- Neil, Sexual differences in the hypothalamic regulation of prolactin secretion (1972) Endocrinology, 90, p. 1154
- Gimeno, Borda, Sterin-Borda, Vida1, Gimeno, Phermacologic influences on human ovarian contractions (1976) Obstet.Gynecol., 47, p. 218
- Ondetti, Rubin, CuBhmen, Design of specific inhibitors of angiotensin-converting enzyme: a new class of orally active antihypertensive agents (1977) Science, 196, p. 441
- Grodzinska, Gryglewski, Angiotensin-induced release of prostacyclin from perfused organs (1980) Pharmacol. Res.COmm., 12, p. 339
- Goodfriend, Simpson, Angiotensin receptors in bovine umbilical artery and their inhibition by nonsteroidal anti-inflamatory drugs (1981) Br.J.Pharmacol., 72, p. 247
- Goldberg, Kadowitz, Greenberg, Indomethecin induced reversal of angiotensin tachyphylaxis: evidence for a non-prostaglandin mechanism (1975) The Pharmacologist, 17, p. 220
- Moore, Hall, Kheirallah, A comparison of the effects of angiotensin II and heptapeptide on smooth muscle (vascular and uterine) (1976) Eur.J.Pharmacol., 39, p. 101
- Hall, Prostaglandin synthesis inhibitors: effect on angiotensin II and oxytocin-induced contractions in rat uterine smooth muscle (1983) Br.J.Pharmac., 79, p. 121
- Sterin-Speziale, Gimeno, Bonacossa, Gimeno, The effect of estradiol on isolated rat uterine motility and on prostaglandin generation (1980) Prostaglandins, 20, p. 233
- Franchi, Bonacossa, Gimeno, Gimeno, Effect of progesterone on the spontaneous motility and prostaglandin synthesis in uterine horns (1982) Prostaglandins, 23, p. 819
- Holmes, Horton, Main, The effect of prostaglandin E1 on responses of smooth muscle to catecholamines, angiotensin and vasopressin (1963) Br.J. Chemother., 21, p. 538
- Borda, Contreras-Ortiz, Gutnisky, Gimeno, In vitro effect of acetylcholine and bethanechol on the contractions of the human detrusor muscle. Influence of prostaglandins (1982) Arch.int.Pharmacodyn.Therap., 259, p. 31
- Clegg, Antagonism by prostaglandins of the response of various smooth muscle preparations to sympathomimetics (1966) Nature, 269, p. 1137
- Borda, Agostini, Sterin-Borda, Gimeno, Gimeno, Inhibitory effects of some catecholamines on contractions of uterine strips isolated from estrous and spayed rats. Influence of endogenous and exogenous prostaglandins on the action of meteroxamine (1981) Eur.J. Pharmacol., 69, p. 55
Citas:
---------- APA ----------
Chaud, M., Viggiano, M., Gimeno, M.F. & Gimeno, A.L. (1984) . Prostaglandins and the contractile effect of angiotensin i and ii in the uterus isolated from ouariectomized rats. influence*of indo methacin and 17-β estradiol. Prostaglandins, Leukotrienes and Medicine, 16(2), 225-234.http://dx.doi.org/10.1016/0262-1746(84)90073-8
---------- CHICAGO ----------
Chaud, M., Viggiano, M., Gimeno, M.F., Gimeno, A.L. "Prostaglandins and the contractile effect of angiotensin i and ii in the uterus isolated from ouariectomized rats. influence*of indo methacin and 17-β estradiol" . Prostaglandins, Leukotrienes and Medicine 16, no. 2 (1984) : 225-234.http://dx.doi.org/10.1016/0262-1746(84)90073-8
---------- MLA ----------
Chaud, M., Viggiano, M., Gimeno, M.F., Gimeno, A.L. "Prostaglandins and the contractile effect of angiotensin i and ii in the uterus isolated from ouariectomized rats. influence*of indo methacin and 17-β estradiol" . Prostaglandins, Leukotrienes and Medicine, vol. 16, no. 2, 1984, pp. 225-234.http://dx.doi.org/10.1016/0262-1746(84)90073-8
---------- VANCOUVER ----------
Chaud, M., Viggiano, M., Gimeno, M.F., Gimeno, A.L. Prostaglandins and the contractile effect of angiotensin i and ii in the uterus isolated from ouariectomized rats. influence*of indo methacin and 17-β estradiol. Prostaglandins Leukotrienes Med. 1984;16(2):225-234.http://dx.doi.org/10.1016/0262-1746(84)90073-8
